Results 41 to 50 of about 4,236,805 (394)

Quantitative prediction of multivalent ligand–receptor binding affinities for influenza, cholera, and anthrax inhibition [PDF]

, 2018
Multivalency achieves strong, yet reversible binding by the simultaneous formation of multiple weak bonds. It is a key interaction principle in biology and promising for the synthesis of high-affinity inhibitors of pathogens. We present a molecular model
Liese, Susanne, Netz, Roland R.
core   +2 more sources

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]

, 2014
Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Goulet, Adeline, Grossmann, S.P., Jung, Y., Major, J., Moores, Carolyn A., Rosenfeld, S.S.   +5 more
core   +3 more sources

Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy

Molecules, 2017
Antibody-drug conjugates (ADCs) are a class of highly potent biopharmaceutical drugs generated by conjugating cytotoxic drugs with specific monoclonal antibodies through appropriate linkers.
Hao Chen, Zongtao Lin, Kinsie E. Arnst, Duane D. Miller, Wei Li   +4 more
doaj   +1 more source

Redox-active ferrocene-modified Cowpea mosaic virus nanoparticles [PDF]

, 2010
A naturally occurring nanoparticle, the plant virus Cowpea mosaic virus, can be decorated with ferrocene derivatives, of various linker lengths with amine and carboxylategroups, on the external surface using a range of conjugation strategies.
Alaa A. A. Aljabali, Astruc, Beasley, Chatterji, Chidsey, Constable, David J. Evans, Evans, Evans, Frederix, George P. Lomonossoff, Green, J. Elaine Barclay, Julea N. Butt, Lin, Lomonossoff, Lopez, Molina, Newkome, Padeste, Steinmetz, Steinmetz, Steinmetz, Togni, Wang, Wang, Wellink, Yang, Yang   +28 more
core   +1 more source

The control technology of harmful substances impacting the quality of peanut oil: A review

Grain & Oil Science and Technology
Peanut is a globally important leguminous crop and one of the most important oil crops. In response to the growing demand for high-quality peanut oil, advancements in processing technologies have led to significant improvements in oil quality.
Zifu Ni, Xiao Ouyang, Azhen Nie, Lina Huang, Ruoqi Li, Jinling Li, Peng Chen   +6 more
doaj   +1 more source

Discovery of potent histone deacetylase inhibitors with modified phenanthridine caps

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
In discovery of novel HDAC inhibitory with anticancer potency, pharmacophores of phenanthridine were introduced to the structure of HDAC inhibitors. Fatty and aromatic linkers were evaluated for their solubility and activity.
Wenli Fan, Lin Zhang, Xuejiang Wang, Haiyong Jia, Lei Zhang   +4 more
doaj   +1 more source

Exploring Experimental and In Silico Approaches for Antibody–Drug Conjugates in Oncology Therapies

Pharmaceuticals
Background/Objectives: Antibody–drug conjugates are a rapidly evolving class of cancer therapeutics that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs. This review explores experimental and computational advances in
Vitor Martins de Almeida, Milena Botelho Pereira Soares, Osvaldo Andrade Santos-Filho   +2 more
doaj   +1 more source

Synthesis of a New Series of Nitrogen/Sulfur Heterocycles by Linking Four Rings: Indole; 1,2,4-Triazole; Pyridazine; and Quinoxaline

Molecules, 2020
A new series of nitrogen and sulfur heterocyclic systems were efficiently synthesized by linking the following four rings: indole; 1,2,4-triazole; pyridazine; and quinoxaline hybrids. The strength of the acid that catalyzes the condensation of 4-amino-5-(
Ahmed T. A. Boraei, Ahmed A. M. Sarhan, Sammer Yousuf, Assem Barakat   +3 more
doaj   +1 more source

Anti-Fungal Hevein-like Peptides Biosynthesized from Quinoa Cleavable Hololectins

Molecules, 2021
Chitin-binding hevein-like peptides (CB-HLPs) belong to a family of cysteine-rich peptides that play important roles in plant stress and defense mechanisms. CB-HLPs are ribosomally synthesized peptides that are known to be bioprocessed from the following
Shining Loo, Stephanie V. Tay, Antony Kam, Fan Tang, Jing-Song Fan, Daiwen Yang, James P. Tam   +6 more
doaj   +1 more source

Direct Patterning of a Cyclotriveratrylene Derivative for Directed Self-assembly of C60 [PDF]

, 2011
A novel apex-modified cyclotriveratrylene (CTV) derivative with an attached thiolane-containing lipoic acid linker was directly patterned onto gold substrates via dip-pen nanolithography (DPN).
Becker, Daniel P., Holz, Richard C., Nyamjav, Dorjderem, Osner, Zachary R.   +3 more
core   +3 more sources