Results 51 to 60 of about 79,767 (263)
Advanced Science, EarlyView.An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang +10 more
wiley +1 more source
Italian Journal of Animal Science, 2010 Milk fat is the richest natural source of conjugated linoleic acid (CLA) isomers. The 9-cis, 11-trans CLA isomer (rumenic acid, RA) origins from two pathways: as an intermediate of the rumen biohydrogenation process of linoleic acid or as the product of ...
P. Secchiari +4 more
doaj +1 more source
Advanced Science, EarlyView.Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang +10 more
wiley +1 more source
Linoleic acid-induced endothelial activation
Journal of Lipid Research, 2004 Hypertriglyceridemia, an important risk factor of atherosclerosis, is associated with increased circulating free fatty acids. Research to date indicates that linoleic acid (LA), the major fatty acid in the American diet, may be atherogenic by activating ...
Viswanathan Saraswathi +3 more
doaj +1 more source
Advanced Science, EarlyView.Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao +11 more
wiley +1 more source
Advanced Science, EarlyView.Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa +11 more
wiley +1 more source
Modified Titanium Dental Implants: The Current Progress of Soft‐Tissue Integration Methods
Advanced NanoBiomed Research, EarlyView.Dental implants are an established solution for tooth loss, yet achieving soft tissue integration (STI) around the transmucosal region remains a challenge. The natural tooth–gingiva interface is poorly replicated on titanium implants. This review explores surface modification strategies, ranging from surface chemistry and topography to biological ...
Daniel De Maria +5 more
wiley +1 more source
PLoS ONE, 2019 The Colorado Potato Beetle, Leptinotarsa decemlineata, is a major agricultural pest of solanaceous crops in the United States. Historically, a multitude of insecticides have been used to control problematic populations.
Justin Clements +5 more
doaj +1 more source
Radiohomogeneity of H3- and C14-labeled linoleic acid in vivo
Journal of Lipid Research, 1965 A mixture of linoleic acid-1-C14 and linoleic acid labeled with H3 in the chain was administered to rats, and the H3/C14 ratio in the linoleic acid recovered from liver and adipose tissue of the rat was compared with that in the administered mixture ...
Demetrios Sgoutas +2 more
doaj +1 more source
Coadministration of linolenic acid and linoleic acid decreased lipotoxicity in cardiomyocytes.
فصلنامه دانشگاه علوم پزشکی جهرم, 2018 Background: Deleterious effects of lipid accumulation in non-adipose tissues are known as lipotoxicity. The prevalence of cardiovascular disease due to lipotoxicity has been dramatically increased worldwide.
Elham Zadeh Hashem +2 more
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