Results 1 to 10 of about 1,664,116 (319)

Endotoxin-Free Stx2B-C-CPE Vaccine and Its Optimized Adjuvant Regimen for Preventing Food Poisoning

Frontiers in Bioscience-Landmark, 2023
Background: Clostridium perfringens and Shiga toxin (Stx)-producing Escherichia coli (STEC) are common causes of food poisoning. We previously demonstrated the efficacy of Stx2B-C-CPE, a fusion protein of the C-terminal region of C.
Koji Hosomi, Atsushi Shimoyama, Atsushi Hinenoya, Noritoshi Hatanaka, Takafumi Noguchi, Hirotaka Ebina, Yoko Tojima, Mari Furuta, Masuo Kondoh, Hiroshi Kiyono, Shinji Yamasaki, Koichi Fukase, Jun Kunisawa   +12 more
doaj   +1 more source

Lipopolysaccharide: An indispensable source for potential targets and therapeutic design against Gram-negative bacteria

Journal of Clinical and Scientific Research, 2021
Gram-negative bacteria show more drug-resistant than Gram-positive bacteria due to unique structural attribute and cause significant morbidity and mortality across the globe.
Chiranjeevi Pasala, Sudheer Kumar Katari, Ravina Madhulitha Nalamolu, Sharon Priya Alexander, Umakanth Naik Vankadoth, Siva Ranjani Pakala, Amineni Umamaheswari   +6 more
doaj   +1 more source

Prospective assessment of the repercussions on the lipid profile of surgeries involving liposuction and dermolipectomies [PDF]

Revista Brasileira de Cirurgia Plástica, 2019
Introduction: Liposuction associated with dermolipectomies is the most commonly performed surgical procedure in plastic surgery. Although regarded as an extremely safe surgery, some considerations must be taken on the possible metabolic effects of these ...
Leonardo David Pires Barcelos, Jefferson Di Lamartine Galdino Amaral, Marina Borgatto, Gabriel Campelo dos-Santos, Amanda Costa Campos, Ronan Caputi Silva Dias, Juldasio Galdino de Oliveira   +6 more
doaj   +1 more source

Cardiovascular Risk Factors and Subclinical Atherosclerosis in Greek Adolescents with Polycystic Ovary Syndrome: Its Relationship with Body Mass Index

Children, 2021
Polycystic ovary syndrome (PCOS) is the most common endocrine condition affecting 6–18% of adolescents and is strongly associated with obesity and cardiovascular risk factors, enhancing the risk of atherosclerosis.
Anastasia Garoufi, Athanasia Pagoni, Maria Papadaki, Antonios Marmarinos, Georgios Karapostolakis, Lina Michala, Alexandra Soldatou   +6 more
doaj   +1 more source

Plasma Brain Natriuretic Peptide Levels in Children with Chronic Kidney Disease and Renal Transplant Recipients: A Single Center Study

Children, 2022
Pediatric chronic kidney disease (CKD) patients, as well as kidney transplant patients, are at an increased risk of developing cardiovascular disease.
Anastasia Garoufi, Aikaterini Koumparelou, Varvara Askiti, Panagis Lykoudis, Andromachi Mitsioni, Styliani Drapanioti, Georgios Servos, Maria Papadaki, Dimitrios Gourgiotis, Antonios Marmarinos   +9 more
doaj   +1 more source

Protection and Safety Evaluation of Live Constructions Derived from the Pgm⁻ and pPCP1⁻ Yersinia pestis Strain

Vaccines, 2020
Based on a live attenuated Yersinia pestis KIM10(pCD1Ap) strain (Pgm−, pPCP1−), we attempted to engineer its lipid A species to achieve improvement of immunogenicity and safety. A mutant strain designated as YPS19(pCD1Ap), mainly synthesizing
Xiuran Wang, Amit K. Singh, Wei Sun
doaj   +1 more source

Educational strategy to improve cardiovascular health and mitigate food insecurity: Rationale for the E-DUCASS program

Spanish Journal of Medicine, 2022
Introduction and Objectives: Food insecurity is involved in the most important health problem worldwide: the rise in non-communicable diseases. It affects populations in poor countries and disadvantaged populations in affluent countries.
Juan L. Romero-Cabrera, Isabel de-Castro-Burón, Elena Yubero-Serrano, Alberto Díaz-Cáceres, Alejandro Serrán-Jiménez, Javier Arenas-Montes, Juan F. Alcalá-Díaz, Ana M. Ortiz-Morales, Pablo Pérez-Martínez   +8 more
doaj   +1 more source

The Role of Oxidative Stress-Mediated Inflammation in the Development of T2DM-Induced Diabetic Nephropathy: Possible Preventive Action of Tannins and Other Oligomeric Polyphenols

Molecules, 2022
Diabetic nephropathy is manifested in more than 10% of people with diabetes. It is a common cause of kidney failure and end-stage kidney disease. Understanding of mechanisms underlying the initiation and development of diabetes-induced kidney injuries ...
Gohar Sahakyan, Anne Vejux, Naira Sahakyan   +2 more
doaj   +1 more source

Synthesis of C-glycosyl phosphonate derivatives of 4-amino-4-deoxy-α-ʟ-arabinose

Beilstein Journal of Organic Chemistry, 2020
The incorporation of basic substituents into the structurally conserved domains of cell wall lipopolysaccharides has been identified as a major mechanism contributing to antimicrobial resistance of Gram-negative pathogenic bacteria.
Lukáš Kerner, Paul Kosma
doaj   +1 more source

Synthesis of monophosphorylated lipid A precursors using 2-naphthylmethyl ether as a protecting group

Beilstein Journal of Organic Chemistry, 2020
Lipid A, the hydrophobic domain of lipopolysaccharide (LPS), is a strong immunostimulator and therefore a valuable target for the development of novel immunomodulators.
Jundi Xue, Ziyi Han, Gen Li, Khalisha A. Emmanuel, Cynthia L. McManus, Qiang Sui, Dongmian Ge, Qi Gao, Li Cai   +8 more
doaj   +1 more source