Results 11 to 20 of about 858,616 (357)

Enhancing microalgal lipid accumulation for biofuel production

Frontiers in Microbiology, 2022
Microalgae have high lipid accumulation capacity, high growth rate and high photosynthetic efficiency which are considered as one of the most promising alternative sustainable feedstocks for producing lipid-based biofuels.
Zhi Zhu, Zhi Zhu, Zhi Zhu, Zhi Zhu, Jing Sun, Yun Fa, Xufeng Liu, Peter Lindblad   +7 more
doaj   +3 more sources

Lipid Droplet Accumulation Promotes RPE Dysfunction [PDF]

International Journal of Molecular Sciences, 2022
Non-exudative age-related macular degeneration (AMD) is an irreversibly progressive retinal degenerative disease characterized by dysfunction and loss of retinal pigment epithelium (RPE). It has been suggested that impaired phagocytosis of the RPE is involved in the progression of non-exudative AMD, but the mechanism is not fully clear.
Tomohiro Yako, Wataru Otsu, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara   +4 more
openaire   +2 more sources

Astrocytes in stress accumulate lipid droplets [PDF]

Glia, 2021
AbstractWhen the brain is in a pathological state, the content of lipid droplets (LDs), the lipid storage organelles, is increased, particularly in glial cells, but rarely in neurons. The biology and mechanisms leading to LD accumulation in astrocytes, glial cells with key homeostatic functions, are poorly understood.
Tina Smolič, Petra Tavčar, Anemari Horvat, Urška Černe, Ana Halužan Vasle, Larisa Tratnjek, Mateja Erdani Kreft, Nicole Scholz, Maja Matis, Toni Petan, Robert Zorec, Nina Vardjan   +11 more
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BRAF Modulates Lipid Use and Accumulation

Cancers, 2022
There is increasing evidence that oxidative metabolism and fatty acids play an important role in BRAF-driven tumorigenesis, yet the effect of BRAF mutation and expression on metabolism is poorly understood. We examined how BRAF mutation and expression modulates metabolite abundance.
Jacqueline A. Turner, Emily L. Paton, Robert Van Gulick, Davide Stefanoni, Francesca Cendali, Julie Reisz, Richard P. Tobin, Martin McCarter, Angelo D’Alessandro, Raul M. Torres, William A. Robinson, Kasey L. Couts, Isabel R. Schlaepfer   +12 more
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Lipid metabolism and accumulation in oilseed crops [PDF]

OCL, 2021
Triacylglycerols (TAGs) serve as the most important storage form of energy and carbon in eukaryotic cells and thus are one of the fundamental macronutrients for animal and human diet. They are also used as a major feedstock for diverse industrial and energetic sectors due to their high energy density. Oilseed crops represent the most valuable source of
Miklaszewska, Magdalena, Zienkiewicz, Krzysztof, Inchana, Pattarapong, Zienkiewicz, Agnieszka   +3 more
openaire   +4 more sources

Lipid Accumulation and Chronic Kidney Disease [PDF]

Nutrients, 2019
Obesity and hyperlipidemia are the most prevalent independent risk factors of chronic kidney disease (CKD), suggesting that lipid accumulation in the renal parenchyma is detrimental to renal function. Non-esterified fatty acids (also known as free fatty acids, FFA) are especially harmful to the kidneys. A concerted, increased FFA uptake due to high fat
Gai, Zhibo, Wang, Tianqi, Visentin, Michele, Kullak-Ublick, Gerd A, Fu, Xianjun, Wang, Zhenguo   +5 more
openaire   +3 more sources

Human resistin promotes macrophage lipid accumulation [PDF]

Diabetologia, 2006
The gene encoding resistin/FIZZ3 (found in inflammatory zone 3), which is denoted by the gene symbol RETN in humans and Retn in mice, belongs to a new gene family of small cysteine-rich secretory proteins, called ‘resistin-like molecules’, originally discovered in a search for adipocytederived molecules linking obesity and insulin-resistant diabetes [1]
Rae, C., Graham, Annette
openaire   +2 more sources

Cerebral lipid accumulation in Chanarin–Dorfman Syndrome [PDF]

Molecular Genetics and Metabolism, 2015
Chanarin-Dorfman Syndrome (CDS) is caused by a defect in the CGI-58/ABHD5 gene resulting in a deficiency of CGI-58 and in intracellular accumulation of triacylglycerol in skin and liver. Patients are mainly characterized by congenital ichthyosis, but the clinical phenotype is very heterogeneous. Distinct brain involvement has never been described.
Huigen, C.D.G., Huigen, C.D.G., van der Graaf, M., van der Graaf, M., van der Graaf, M., Morava, E., Dassel, A.C., van Steensel, M.A.M., Seyger, M.M.B., Wevers, R.A., Wevers, R.A., Willemsen, M.A., Willemsen, M.A.   +12 more
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Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation [PDF]

Cells, 2021
Microglia become increasingly dysfunctional with aging and contribute to the onset of neurodegenerative disease (NDs) through defective phagocytosis, attenuated cholesterol efflux, and excessive secretion of pro-inflammatory cytokines. Dysfunctional microglia also accumulate lipid droplets (LDs); however, the mechanism underlying increased LD load is ...
Bailey A. Loving, Maoping Tang, Mikaela C. Neal, Sachi Gorkhali, Robert Murphy, Robert H. Eckel, Kimberley D. Bruce   +6 more
openaire   +3 more sources

Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells [PDF]

, 2017
Wolbachia are intracellular maternally inherited bacteria that can spread through insect populations and block virus transmission by mosquitoes, providing an important approach to dengue control.
Ant, Thomas H., Charles, Philip D., Dowle, Adam A., Geoghegan, Vincent, Hester, Svenja, Larson, Tony, Rainey, Stephanie M., Sinkins, Steven P., Stainton, Kirsty, Thomas, Benjamin   +9 more
core   +3 more sources