The role of lipid and lipoprotein metabolism in non-alcoholic fatty liver disease [PDF]
, 2017 Due to the epidemic of obesity across the world, nonalcoholic fatty liver disease (NAFLD) has become one of the most prevalent chronic liver disorders in children and adolescents.
Anania, Caterina +4 more
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ATG2A-mediated bridge-like lipid transport regulates lipid droplet accumulation
, 2023 AbstractATG2 proteins facilitate bulk lipid transport between membranes. ATG2 is an essential autophagy protein, but ATG2 also localizes to lipid droplets (LDs), and genetic depletion of ATG2 increases LD numbers while impairing fatty acid transport from LDs to mitochondria.
Justin L. Korfhage +8 more
openaire +2 more sources
Lipid droplet detection by the cavity perturbation method [PDF]
, 2011 There are currently no point-of-care diagnosis strategies available to indicate the presence of neoplasmic growth. This research aims to develop a novel diagnostic strategy based on detecting TAG accumulation in cells.
A I Al-Shamma'a +7 more
core +1 more source
The pleiotropic transcriptional regulator NlpR contributes to the modulation of nitrogen metabolism, lipogenesis and triacylglycerol accumulation in oleaginous rhodococci [PDF]
, 2017 The regulatory mechanisms involved in lipogenesis and triacylglycerol (TAG) accumulation are largely unknown in oleaginous rhodococci. In this study a regulatory protein (here called NlpR: Nitrogen lipid Regulator), which contributes to the modulation of
Alvarez, Hector Manuel +4 more
core +1 more source
Prenatal hyperandrogenism induces alterations that affect liver lipid metabolism [PDF]
, 2016 Prenatal hyperandrogenism is hypothesized as one of the main factors contributing to26 the development of polycystic ovary syndrome (PCOS). PCOS patients have high risk27 of developing fatty liver and steatosis.
Abruzzese, Giselle Adriana +6 more
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Secondary lipid accumulation in lysosomal disease
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009 Lysosomal diseases are inherited metabolic disorders caused by defects in a wide spectrum of lysosomal and a few non-lysosomal proteins. In most cases a single type of primary storage material is identified, which has been used to name and classify the disorders: hence the terms sphingolipidoses, gangliosidoses, mucopolysaccharidoses, glycoproteinoses,
Walkley, Steven U., Vanier, Marie T.
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Inhibitory effects of compounds from the roots of Potentilla longifolia on lipid accumulation
PLoS ONE, 2020 Potentilla longifolia is a kind of Chaoyao medicine, which is a branch of traditional Chinese medicine. The plant is often referred to as ganyancao or ganyearmcao, which means that it has a significant therapeutic effect on liver inflammation.
Shengxi Lin +9 more
doaj +2 more sources
Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration. [PDF]
, 2015 Background & aimsAll-trans Retinoic acid (RA) regulates hepatic lipid and bile acid homeostasis. Similar to bile acid (BA), RA accelerates partial hepatectomy (PHx)-induced liver regeneration.
Hu, Ying +2 more
core +5 more sources
Naringenin inhibits lipid accumulation by activating the AMPK pathway in vivo and vitro
Food Science and Human Wellness, 2023 The aim of this study was to explore the lipid-lowering effect of naringenin and the underlying mechanism in high-fat-diet-fed SD rats and 3T3-L1 cells. In this study, SD rats were divided into the normal chow diet group (NCD), high fat diet group (HFD),
Xiaoyu Cai +7 more
doaj +1 more source
Targeting MicroRNAs to Limit Myocardial Lipid Accumulation [PDF]
Circulation Research, 2015 Obesity and type 2 diabetes mellitus are major health concerns, with the incidence rapidly rising in the world. Among their many complications is an increased risk of developing heart failure.1,2 This increased incidence of heart failure in obese and diabetic individual occurs even when corrected for the increased prevalence of hypertension and ...
Gary D, Lopaschuk, John R, Ussher
openaire +2 more sources