Results 51 to 60 of about 3,287,800 (353)

Synthesis and accumulation of a receptor regulatory protein associated with lipid droplet accumulation in 3T3-L1 cells

Journal of Lipid Research, 1998
Synthesis and accumulation of the recently identified prostaglandin F2α receptor regulatory protein (FPRP) was found to correlate closely with lipid droplet accumulation by 3T3-L1 preadipose cells.
D.J. Orlicky, J.G. Lieber, C.L. Morin, R.M. Evans   +3 more
doaj   +1 more source

Antioxidant activities of plant extracts and essential oil-cyclodextrin complexes and their effect on lipid accumulation in porcine adipocytes in vitro

Veterinary Integrative Sciences, 2021
Fat deposition is important for pig production because excessive fat decreases the economic value of meat production. Plant extracts have been used as feed additive in pig diets to improve oxidative stability of meat. However, only a few studies
Rakkiat Norkeaw, Chaiwat Arjin, Apinya Sartsook, Niraporn Chaiwang, Supamit Mekchay, Sarana Rose Sommano, Warintorn Ruksiriwanich, Korawan Sringarm   +7 more
doaj   +1 more source

The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells [PDF]

, 2016
Dietary overload of toxic, free metabolic intermediates leads to disrupted insulin signalling and fatty liver disease. However, it was recently reported that this pathway might not be universal: depletion of histone deacetylase (HDAC) enhances insulin ...
Enejder, Annika, Hagman, Henning, Kiskis, Juris, Levrero, Massimo, Nunn, Abigail D. G., Pediconi, Natalia, Scopigno, Tullio   +6 more
core   +1 more source

Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases

Cell & Bioscience, 2022
The importance of neuroglia in maintaining normal brain function under physiological and pathological conditions has been supported by growing evidence in recent years.
Danying Yang, Xifeng Wang, Lieliang Zhang, Yang Fang, Qingcui Zheng, Xing Liu, Wen Yu, Shoulin Chen, Jun Ying, Fuzhou Hua   +9 more
doaj   +1 more source

Development of a novel tocopheryl ester for suppression of lipid accumulation without cytotoxicity by optimization of dicarboxylic ester moiety

Biochemistry and Biophysics Reports, 2022
Tocopheryl succinate (Tsuc) is a succinic acid ester of the well-known antioxidant α-tocopherol (T). Tsuc exhibits various biological activities, including tumor growth suppression via activation of cell signaling and prevention of lipid accumulation in ...
Misaki Yamasaki, Yuika Seto, Mizune Ozono, Michiyasu Nakao, Akira Shigenaga, Akira Otaka, Shigeki Sano, Kentaro Kogure   +7 more
doaj   +1 more source

Nonalcoholic Lipid Accumulation and Hepatocyte Malignant Transformation [PDF]

Journal of Clinical and Translational Hepatology, 2016
Worldwide incidence of hepatocellular carcinoma (HCC) is steadily increasing, highlighting its status as a public health concern, particularly due to its significant association with other comorbidities, such as diabetes. However, nonalcoholic fatty liver disease (NAFLD) has emerged as a primary risk factor, with its own prevalence increasing in recent
Gu, Juanjuan, Yao, Min, Yao, Dengbing, Wang, Li, Yang, Xuli, Yao, Dengfu   +5 more
openaire   +2 more sources

Lipid storage and autophagy in melanoma cancer cells [PDF]

, 2017
Cancer stem cells (CSC) represent a key cellular subpopulation controlling biological features such as cancer progression in all cancer types. By using melanospheres established from human melanoma patients, we compared less differentiated melanosphere ...
Cordella, Martina, Eramo, A, Facchiano, A, Facchiano, F, Filippini, Antonio, Giampietri, Claudia, Petrungaro, Simonetta, Tabolacci, C, Tomaipitinca, Luana, Ziparo, Elio   +9 more
core   +2 more sources

Exploiting Bioprocessing Fluctuations to Elicit the Mechanistics of De Novo Lipogenesis in Yarrowia lipolytica. [PDF]

PLoS ONE, 2017
Despite substantial achievements in elucidating the metabolic pathways of lipogenesis, a mechanistic representation of lipid accumulation and degradation has not been fully attained to-date.
Andreas E Vasdekis, Andrew M Silverman, Gregory Stephanopoulos   +2 more
doaj   +1 more source

Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis

Molecular Metabolism, 2022
Objective: Aberrant ketogenesis is correlated with the degree of steatosis in non-alcoholic fatty liver disease (NAFLD) patients, and an inborn error of ketogenesis (mitochondrial HMG-CoA synthase deficiency) is commonly associated with the development ...
Shaza Asif, Ri Youn Kim, Thet Fatica, Jordan Sim, Xiaoling Zhao, Yena Oh, Alix Denoncourt, Angela C. Cheung, Michael Downey, Erin E. Mulvihill, Kyoung-Han Kim   +10 more
doaj   +1 more source

ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis

Journal of Translational Medicine
Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose global prevalence is rapidly increasing. Acetyl CoA carboxylases 1 (ACACA) is the key enzyme that controls the rate of fatty acid synthesis.
Jian Dong, Muzi Li, Runsheng Peng, Yuchuan Zhang, Zilin Qiao, Na Sun   +5 more
semanticscholar   +1 more source