Results 91 to 100 of about 107,533 (320)

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Field Theoretic Study of Bilayer Membrane Fusion III: Membranes with Leaves of Different Composition

, 2006
We extend previous work on homogeneous bilayers to calculate the barriers to fusion of planar bilayers which contain two different amphiphiles, a lamellae-former and a hexagonal former, with different compositions of the twoin each leaf.
Bailey, Chernomordik, Chernomordik, Cohen, Devaux, Discher, Eastman, Evans, Groot, Gruner, Hope, Hope, J.Y. Lee, Kasson, Katsov, Katsov, Kozlov, Kozlovsky, Kozlovsky, Kuzmin, Lentz, Leontiadou, Li, Loison, M. Schick, Malinin, Malinin, Markin, Marrink, Müller, Müller, Noguchi, Rothman, Seigneuret, Siegel, Siegel, Smeijers, Stevens, Tieleman, Tolpekina   +39 more
core   +2 more sources

PH regulation of amphotericin B channels activity in the bilayer lipid membrane [PDF]

, 2016
Background: Amphotericin B (AmB) is a polyene antibiotic frequently applied in the treatment of systemic fungal infections in spite of its secondary effects.
Ashrafpour, M., Sepehry, H., Shahmoradi, T.   +2 more
core   +2 more sources

Transmembrane Activation of Catalysis and Protein Refolding in Synthetic Cells by Enzymes and Nanozymes

Advanced Functional Materials, EarlyView.
Synthetic cells are engineered herein to respond to an external chemical messenger by the activation of intracellular catalysis. The chemical messenger molecules are catalytically generated by an extracellular enzyme or a mineral surface, whereas the intracellular catalysis emerges via direct enzyme activation or via protein refolding.
Dante G. Andersen, Andreas B. Pedersen, Mireia Casanovas Montasell, Søren Moesgaard, Anja Bille Bohn, Alexander N. Zelikin   +5 more
wiley   +1 more source

Cell-free protein expression systems in microdroplets: stabilization of interdroplet bilayers

, 2013
Cell-free protein expression with bacterial lysates has been demonstrated to produce soluble proteins in microdroplets. However, droplet assays with expressed membrane proteins require the presence of a lipid bilayer.
Hywel Morgan, Mark S. Friddin, Maurits R. R. de Planque, Patnaik R.   +3 more
core   +1 more source

The interaction of amyloid A beta(1-40) with lipid bilayers and ganglioside as studied by P-31 solid-state NMR [PDF]

, 2009
Amyloid P-peptide (A beta) is a major component of plaques in Alzheimer's disease, and formation of senile plaques has been suggested to originate fro m regions of neuronal membrane rich in gangliosides. We analyzed the mode of interaction of A beta with
Asakura, T., Nakazawa, Y., Saito, H., Suzuki, Y., Williamson, M.P.   +4 more
core   +1 more source

Kirigami‐Inspired Breathable Smart Contact Lens for Wireless Monitoring of Corneal Hypoxia and Microenvironment

Advanced Healthcare Materials, EarlyView.
A kirigami‐inspired breathable smart contact lens is reported for wireless monitoring of corneal hypoxia and microenvironment. The ultrathin (55 µm) and flexible sensing device enables digitalized, in situ and precise monitoring of dissolved oxygen, humidity, and temperature (R2 >0.98).
Jiaxue Zhu, Ling Yang, Qing Yang, Yin Huang, Yuhang Li, Yueqing He, Xuxu Yang, Zhiyan Yang, Yonghong Jiao, Wenbin Wei, Yihao Chen, Xue Feng   +11 more
wiley   +1 more source

Flexible Lipid Bilayers in Implicit Solvent [PDF]

, 2005
A minimalist simulation model for lipid bilayers is presented. Each lipid is represented by a flexible chain of beads in implicit solvent. The hydrophobic effect is mimicked through an intermolecular pair potential localized at the ``water''/hydrocarbon tail interface.
arxiv   +1 more source

On Shape Transformations and Shape Fluctuations of Cellular Compartments and Vesicles [PDF]

, 1993
We discuss the shape formation and shape transitions of simple bilayer vesicles in context with their role in biology. In the first part several classes of shape changes of vesicles of one lipid component are described and it is shown that these can be ...
Berndl K, Bessis M, Bloom M, Darnell J, Döbereiner H G, E Sackmann, Evans E, Gebhardt C, Helfrich W, Helfrich W, J Käs, J Rädler, Käs J, Leibler S, Petrov A, Sackmann E, Sackmann E, Seifert U, Zilker A   +18 more
core   +1 more source

Magnesium-Induced Lipid Bilayer Microdomain Reorganizations: Implications for Membrane Fusion [PDF]

The Journal of Physical Chemistry B, 2009
Interactions between dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylserine (DPPS), combined both as binary lipid bilayer assemblies and separately, under the influence of divalent Mg2+, a membrane bilayer fusogenic agent, are reported.
Ira W. Levin, E. Neil Lewis, Fraser K. McNeil-Watson, Zachary D. Schultz, Ileana M. Pazos   +4 more
openaire   +3 more sources