Results 51 to 60 of about 2,675,614 (299)

Spastin Binds to Lipid Droplets and Affects Lipid Metabolism

PLOS Genetics, 2015
Mutations in SPAST, encoding spastin, are the most common cause of autosomal dominant hereditary spastic paraplegia (HSP). HSP is characterized by weakness and spasticity of the lower limbs, owing to progressive retrograde degeneration of the long corticospinal axons.
Papadopoulos, Chrisovalantis, Orso, Genny, Mancuso, Giuseppe, Herholz, Marija, Gumeni, Sentiljana, Tadepalle, Nimesha, Jüngst, Christian, Tzschichholz, Anne, Schauss, Astrid, Höning, Stefan, Trifunovic, Aleksandra, Daga, Andrea, Rugarli, Elena I.   +12 more
openaire   +4 more sources

Neural Stem Cell Spreading on Lipid Based Artificial Cell Surfaces, Characterized by Combined X-ray and Neutron Reflectometry [PDF]

, 2010
We developed a bioadhesive coating based on a synthetic peptide-conjugate (AK-cycloRGDfC]) which contains multiples of the arginyl-glycyl-aspartic acid (RGD) amino acid sequence.
Gabor Mezo, Huth, M, Madarasz, E., Mezo, G., Hertrich, S, Madarasz, Emilia, Nickel, B., Mezo, Gabor, Bert Nickel, Huth, Martin, Martin Huth, Mező, G, Madarasz, E, Nickel, B, Hertrich, S., Samira Hertrich, Hertrich, Samira, Huth, M., Emilia Madarasz, Nickel, Bert   +19 more
core   +1 more source

The lipid‐binding side of Notch ligands [PDF]

The EMBO Journal, 2017
Notch signaling is adjusted to different physiological contexts by expression patterns of Notch ligands and receptors, as well as by posttranslational modifications that modulate the ligand/receptor affinity. In this issue of The EMBO Journa l, Suckling et al (2017) show that an interaction of Notch ligands with membrane lipids promotes Notch ...
Ben‐Zion Shilo, David Sprinzak
openaire   +2 more sources

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Human apolipoprotein E7: lysine mutations in the carboxy-terminal domain are directly responsible for preferential binding to very low density lipoproteins

Journal of Lipid Research, 2000
Apolipoprotein E7 (apoE7) (apoE3 E244K/E245K) is a naturally occurring mutant in humans that is associated with increased plasma lipid levels and accelerated atherosclerosis.
Jun Dong, Maureen E. Balestra, Yvonne M. Newhouse, Karl H. Weisgraber   +3 more
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Druggable Lipid Binding Sites in Pentameric Ligand-Gated Ion Channels and Transient Receptor Potential Channels

Frontiers in Physiology, 2022
Lipids modulate the function of many ion channels, possibly through direct lipid-protein interactions. The recent outpouring of ion channel structures by cryo-EM has revealed many lipid binding sites.
Wayland W. L. Cheng, Mark J. Arcario, John T. Petroff   +2 more
doaj   +1 more source

Lipid binding-induced conformational changes in the N-terminal domain of human apolipoprotein E

Journal of Lipid Research, 1999
The N-terminal domain of human apolipoprotein E3 (apoE3) adopts an elongated, globular four helix bundle conformation in the lipid-free state. Upon lipid binding, the protein is thought to undergo a significant conformational change that is essential for
Carl A. Fisher, Robert O. Ryan
doaj   +1 more source

Redundant and Diversified Roles Among Selected Arabidopsis thaliana EXO70 Paralogs During Biotic Stress Responses

Frontiers in Plant Science, 2020
The heterooctameric vesicle-tethering complex exocyst is important for plant development, growth, and immunity. Multiple paralogs exist for most subunits of this complex; especially the membrane-interacting subunit EXO70 underwent extensive amplification
Tamara Pečenková, Tamara Pečenková, Andrea Potocká, Martin Potocký, Martin Potocký, Jitka Ortmannová, Matěj Drs, Matěj Drs, Edita Janková Drdová, Edita Janková Drdová, Přemysl Pejchar, Přemysl Pejchar, Lukáš Synek, Hana Soukupová, Viktor Žárský, Viktor Žárský, Fatima Cvrčková   +16 more
doaj   +1 more source