Results 31 to 40 of about 1,084,218 (302)

Goldilocks Dilemma: LPS Works Both as the Initial Target and a Barrier for the Antimicrobial Action of Cationic AMPs on E. coli

Biomolecules, 2023
Antimicrobial peptides (AMPs) are generally membrane-active compounds that physically disrupt bacterial membranes. Despite extensive research, the precise mode of action of AMPs is still a topic of great debate.
Martin Jakubec, Fredrik G. Rylandsholm, Philip Rainsford, Mitchell Silk, Maxim Bril’kov, Tone Kristoffersen, Eric Juskewitz, Johanna U. Ericson, John Sigurd M. Svendsen   +8 more
doaj   +1 more source

Role of individual amino acids of apolipoprotein A-I in the activation of lecithin:cholesterol acyltransferase and in HDL rearrangements

Journal of Lipid Research, 2001
The central region of apolipoprotein A-I (apoA-I), spanning residues 143–165, has been implicated in lecithin:cholesterol acyltransferase (LCAT) activation and also in high density lipoprotein (HDL) structural rearrangements.
Kyung-Hyun Cho, Diane M. Durbin, Ana Jonas   +2 more
doaj   +1 more source

Sphingomyelin and GM1 Influence Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes [PDF]

, 2018
Huntington disease (HD) is an inherited neurodegenerative disease caused by the expansion beyond a critical threshold of a polyglutamine (polyQ) tract near the N-terminus of the huntingtin (htt) protein. Expanded polyQ promotes the formation of a variety
Campbell, Warren A., Chaibva, Maxmore, Frey, Shelli L., Gao, Xiang, Jain, Pranav, Legleiter, Justin   +5 more
core   +4 more sources

Molecular Insight into Ligand Binding and Transport by the Lentil Lipid Transfer Protein Lc-LTP2: The Role of Basic Amino Acid Residues at Opposite Entrances to the Hydrophobic Cavity

Biomolecules, 2023
Lipid transfer proteins (LTPs) realize their functions in plants due to their ability to bind and transport various ligands. Structures of many LTPs have been studied; however, the mechanism of ligand binding and transport is still not fully understood ...
Daria N. Melnikova, Ivan V. Bogdanov, Andrey E. Potapov, Anna S. Alekseeva, Ekaterina I. Finkina, Tatiana V. Ovchinnikova   +5 more
doaj   +1 more source

Lipids and lipid binding proteins: A perfect match [PDF]

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2015
Lipids serve a great variety of functions, ranging from structural components of biological membranes to signaling molecules affecting various cellular functions. Several of these functions are related to the unique physico-chemical properties shared by all lipid species, i.e., their hydrophobicity.
openaire   +3 more sources

A Soluble Fluorescent Binding Assay Reveals PIP2 Antagonism of TREK-1 Channels

Cell Reports, 2017
Lipid regulation of ion channels by low-abundance signaling lipids phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid (PA) has emerged as a central cellular mechanism for controlling ion channels and the excitability of nerves.
Cerrone Cabanos, Miao Wang, Xianlin Han, Scott B. Hansen   +3 more
doaj   +1 more source

Beneficial Impacts of Incorporating the Non-Natural Amino Acid Azulenyl-Alanine into the Trp-Rich Antimicrobial Peptide buCATHL4B

Biomolecules, 2021
Antimicrobial peptides (AMPs) present a promising scaffold for the development of potent antimicrobial agents. Substitution of tryptophan by non-natural amino acid Azulenyl-Alanine (AzAla) would allow studying the mechanism of action of AMPs by using ...
Areetha R. D’Souza, Matthew R. Necelis, Alona Kulesha, Gregory A. Caputo, Olga V. Makhlynets   +4 more
doaj   +1 more source

Lipid-binding properties of TRIM72

BMB Reports, 2012
TRIM72 is known to play a critical role in skeletal muscle membrane repair. To better understand the molecular mechanisms of this protein, we carried out an in vitro binding study with TRIM72. Our study proved that TRIM72 binds various lipids with dissociation constants (K(d)) ranging from 88.2 ± 9.9 nM to 550.5 ± 134.5 nM.
Sunghyen, Kim, Jeonghwa, Seo, Young-Gyu, Ko, Young-Duk, Huh, Heonyong, Park   +4 more
openaire   +2 more sources

2014 REU Poster: Quantifying Lipid Contents In Liposomes with Enveloped Plasmonic Nanoparticles [PDF]

, 2014
Poster presentation at REU Summer's End Research Symposium, 2014, by REU participant Beatrix Seytono, Calhoun Community College - Bjoern Reinhard group, Amin Feizpour lab mentor.Phosphatidylserine(PS) and monosialotetrahexosylganglioside(GM1) are ...
Seytono, Beatrix
core   +5 more sources

Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem. [PDF]

, 2019
Rap1 GTPases bind effectors, such as RIAM, to enable talin1 to induce integrin activation. In addition, Rap1 binds directly to the talin1 F0 domain (F0); however, this interaction makes a limited contribution to integrin activation in CHO cells or ...
Alexandre R. Gingras, Andrew J. Valadez, Anthis, Bromberger, Calderwood, Camp, Critchley, Frederic Lagarrigue, Frojmovic, Gingras, Goult, Haling, Han, Hynes, Klapproth, Klaus Ley, Lagarrigue, Lagarrigue, Lee, Marcus Zorovich, Mark H. Ginsberg, Miguel Alejandro Lopez-Ramirez, Monica N. Cuevas, Nicolas Seban, Nieswandt, O’Toole, Petrich, Petrich, Plak, Shattil, Shattil, Simonson, Song, Stefanini, Stritt, Su, Sun, Tadokoro, Vranken, Wegener, William B. Kiosses, Wilma McLaughlin, Ye, Zeiler, Zhu   +44 more
core   +2 more sources