Results 31 to 40 of about 2,675,614 (299)
Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily
Membranes, 2015 The human genome encodes about 285 proteins that contain at least one annotated pleckstrin homology (PH) domain. As the first phosphoinositide binding module domain to be discovered, the PH domain recruits diverse protein architectures to cellular ...
Marc Lenoir +3 more
doaj +1 more source
Frontiers in Chemistry, 2020 During their infective stages, hookworms release excretory-secretory (E-S) products, small molecules, and proteins to help evade and suppress the host's immune system.
Ola El Atab +8 more
doaj +1 more source
Biomolecules, 2023 Lipid transfer proteins (LTPs) realize their functions in plants due to their ability to bind and transport various ligands. Structures of many LTPs have been studied; however, the mechanism of ligand binding and transport is still not fully understood ...
Daria N. Melnikova +5 more
doaj +1 more source
Biophysical characterization of reactions associated with reverse cholesterol transport [PDF]
, 2012 This thesis aimed at improving our understanding of reactions relevant in the reverse cholesterol transport (RCT). RCT facilitates cholesterol homeostasis and is the most important pathway involved in cardiovascular disease.
Zehender, Fabian
core +1 more source
Biomolecules, 2021 Antimicrobial peptides (AMPs) present a promising scaffold for the development of potent antimicrobial agents. Substitution of tryptophan by non-natural amino acid Azulenyl-Alanine (AzAla) would allow studying the mechanism of action of AMPs by using ...
Areetha R. D’Souza +4 more
doaj +1 more source
Lipid-binding properties of TRIM72
BMB Reports, 2012 TRIM72 is known to play a critical role in skeletal muscle membrane repair. To better understand the molecular mechanisms of this protein, we carried out an in vitro binding study with TRIM72. Our study proved that TRIM72 binds various lipids with dissociation constants (K(d)) ranging from 88.2 ± 9.9 nM to 550.5 ± 134.5 nM.
Sunghyen, Kim +4 more
openaire +2 more sources
Lipid-binding properties of selected giardial PIP-binding domains.
, 2020 (A) Membrane-supported lipid arrays spotted with gradients of different phosphorylated variants of phosphatidylinositol (PtdIns), from 100pmol (A) to 1.56pmol/spot (G), were probed with fixed amounts (2.5 μg) of clathrin assemblies-associated epitope ...
Adrian B. Hehl (8486709) +2 more
core +1 more source
Artificial tissue binding models : development and comparative evaluation of high - throughput lipophilicity assays and their use for PET tracer optimization [PDF]
, 2015 The purpose of this thesis was to increase the efficiency of the Positron Emission Tomography (PET) tracer development process. Since many neuroimaging agents fail due to undesirably high non-specific binding (NSB) to brain tissue, we aimed at estimating
Assmus, Frauke
core +1 more source
Calmodulin binds to maize lipid transfer protein and modulates its lipids binding ability [PDF]
The FEBS Journal, 2008 Although plant non‐specific lipid transfer proteins (ns‐LTPs) are characterized by their ability to bind and transfer a broad range of hydrophobic ligands in vitro, their biological functions in vivo remain unclear. Recently, it has been proposed that ns‐LTPs may play a key role in plant defense mechanisms, particularly during the induction of systemic
Cuifeng, Li +5 more
openaire +2 more sources
Designer lipid-like peptides [PDF]
, 2011 A crucial bottleneck in membrane protein studies, particularly G-protein coupled receptors, is the notorious difficulty of finding an optimal detergent that can solubilize them and maintain their stability and function. Here we report rapid production of
Braun, Dieter +11 more
core +1 more source