Results 11 to 20 of about 1,084,218 (302)

Interaction between the Lentil Lipid Transfer Protein Lc-LTP2 and Its Novel Signal Ligand PI(4,5)P2

Membranes, 2020
It is known that plant lipid transfer proteins (LTPs) bind a broad spectrum of ligands including fatty acids (FAs), phospho- and glycolipids, acyl-coenzyme A and secondary metabolites.
Daria Melnikova, Ivan Bogdanov, Tatiana Ovchinnikova, Ekaterina Finkina   +3 more
doaj   +1 more source

Lipids and Lipid-Binding Proteins in Selective Autophagy

Journal of Molecular Biology, 2020
Eukaryotic cells have the capacity to degrade intracellular components through a lysosomal degradation pathway called macroautophagy (henceforth referred to as autophagy) in which superfluous or damaged cytosolic entities are engulfed and separated from the rest of the cell constituents into double membraned vesicles known as autophagosomes ...
Rodriguez de la Ballina, Laura, Munson, Michael Joseph, Simonsen, Anne   +2 more
openaire   +3 more sources

How Honey Bee Vitellogenin Holds Lipid Cargo: A Role for the C-Terminal

Frontiers in Molecular Biosciences, 2022
Vitellogenin (Vg) is a phylogenetically broad glycolipophosphoprotein. A major function of this protein is holding lipid cargo for storage and transportation.
Vilde Leipart, Øyvind Halskau, Gro V. Amdam, Gro V. Amdam   +3 more
doaj   +1 more source

Molecular Analysis of Membrane Targeting by the C2 Domain of the E3 Ubiquitin Ligase Smurf1

Biomolecules, 2020
SMAD ubiquitination regulatory factor 1 (Smurf1) is a Nedd4 family E3 ubiquitin ligase that regulates cell motility, polarity and TGFβ signaling. Smurf1 contains an N-terminal protein kinase C conserved 2 (C2) domain that targets cell membranes and is ...
Jordan L. Scott, Cary T. Frick, Kristen A. Johnson, Haining Liu, Sylvia S. Yong, Allyson G. Varney, Olaf Wiest, Robert V. Stahelin   +7 more
doaj   +1 more source

Novel Roles of SH2 and SH3 Domains in Lipid Binding

Cells, 2021
Signal transduction, the ability of cells to perceive information from the surroundings and alter behavior in response, is an essential property of life. Studies on tyrosine kinase action fundamentally changed our concept of cellular regulation.
Szabolcs Sipeki, Kitti Koprivanacz, Tamás Takács, Anita Kurilla, Loretta László, Virag Vas, László Buday   +6 more
doaj   +1 more source

Inverse Conformational Selection in Lipid–Protein Binding [PDF]

Journal of the American Chemical Society, 2021
Interest in lipid interactions with proteins and other biomolecules is emerging not only in fundamental biochemistry but also in the field of nanobiotechnology where lipids are commonly used, for example, in carriers of mRNA vaccines. The outward-facing components of cellular membranes and lipid nanoparticles, the lipid headgroups, regulate membrane ...
Bacle, Amélie, Buslaev, Pavel, Garcia-Fandino, Rebeca, Favela-Rosales, Fernando, Mendes, Ferreira Tiago, Fuchs, Patrick F. J., Gushchin, Ivan, Javanainen, Matti, Kiirikki, Anne M., Madsen, Jesper J., Melcr, Josef, Milán, Rodríguez Paula, Miettinen, Markus S., Ollila, O. H. Samuli, Papadopoulos, Chris G., Peón, Antonio, Piggot, Thomas J., Piñeiro, Ángel, Virtanen, Salla, I.   +19 more
openaire   +11 more sources

Necator americanus Ancylostoma Secreted Protein-2 (Na-ASP-2) Binds an Ascaroside (ascr#3) in Its Fatty Acid Binding Site

Frontiers in Chemistry, 2020
During their infective stages, hookworms release excretory-secretory (E-S) products, small molecules, and proteins to help evade and suppress the host's immune system.
Ola El Atab, Rabih Darwiche, Rabih Darwiche, Nathanyal J. Truax, Roger Schneiter, Kenneth G. Hull, Daniel Romo, Oluwatoyin A. Asojo, Oluwatoyin A. Asojo   +8 more
doaj   +1 more source

Binding kinetics of membrane-anchored receptors and ligands: molecular dynamics simulations and theory [PDF]

, 2015
The adhesion of biological membranes is mediated by the binding of membrane-anchored receptor and ligand proteins. Central questions are how the binding kinetics of these proteins is affected by the membranes and by the membrane anchoring of the proteins.
Hu, Jinglei, Lipowsky, Reinhard, Weikl, Thomas R., Xu, Guang-Kui   +3 more
core   +2 more sources

Antimicrobial Peptide-Lipid Binding Interactions and Binding Selectivity [PDF]

Biophysical Journal, 2007
Surface pressure measurements, external reflection-Fourier transform infrared spectroscopy, and neutron reflectivity have been used to investigate the lipid-binding behavior of three antimicrobial peptides: melittin, magainin II, and cecropin P1. As expected, all three cationic peptides were shown to interact more strongly with the anionic lipid, 1,2 ...
Lad, Mitaben D., Birembaut, Fabrice, Clifton, Luke A., Frazier, Richard A., Webster, John R.P., Green, Rebecca J.   +5 more
openaire   +2 more sources

Disruption of the C-terminal helix by single amino acid deletion is directly responsible for impaired cholesterol efflux ability of apolipoprotein A-I Nichinan

Journal of Lipid Research, 2010
Apolipoprotein A-I (apoA-I) Nichinan, a naturally occurring variant with ΔE235 in the C terminus, is associated with low plasma HDL levels. Here, we investigated the tertiary structure, lipid-binding properties, and ability to induce cellular cholesterol
Momoe Kono, Toshitaka Tanaka, Masafumi Tanaka, Charulatha Vedhachalam, Palaniappan S. Chetty, David Nguyen, Padmaja Dhanasekaran, Sissel Lund-Katz, Michael C. Phillips, Hiroyuki Saito   +9 more
doaj   +1 more source