The Minor Matrix Protein VP24 from Ebola Virus Lacks Direct Lipid-Binding Properties
Viruses, 2020 Viral protein 24 (VP24) from Ebola virus (EBOV) was first recognized as a minor matrix protein that associates with cellular membranes. However, more recent studies shed light on its roles in inhibiting viral genome transcription and replication ...
Yuan Su, Robert V. Stahelin
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The minor house dust mite allergen Der p 13 is a fatty acid binding protein and an activator of a TLR2-mediated innate immune response [PDF]
, 2016 Background: The house dust mite (HDM) allergen Der p 13 could be a lipid-binding protein able to activate key innate signaling pathways in the initiation of the allergic response.
Banerjee +44 more
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Calmodulin binds to maize lipid transfer protein and modulates its lipids binding ability [PDF]
The FEBS Journal, 2008 Although plant non‐specific lipid transfer proteins (ns‐LTPs) are characterized by their ability to bind and transfer a broad range of hydrophobic ligands in vitro, their biological functions in vivo remain unclear. Recently, it has been proposed that ns‐LTPs may play a key role in plant defense mechanisms, particularly during the induction of systemic
Cuifeng, Li +5 more
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Galectin-12 in Cellular Differentiation, Apoptosis and Polarization. [PDF]
, 2018 Galectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recognition domains ...
Liu, Fu-Tong, Wan, Lei, Yang, Ri-Yao
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Lipid-free Antigen B subunits from echinococcus granulosus: oligomerization, ligand binding, and membrane interaction properties [PDF]
, 2015 Background: The hydatid disease parasite Echinococcus granulosus has a restricted lipid metabolism, and needs to harvest essential lipids from the host.
Córsico, Betina +5 more
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Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines [PDF]
, 1996 A powerful and potentially general approach to the targeting and crystallization of proteins on lipid interfaces through coordination of surface histidine residues to lipid-chelated divalent metal ions is presented.
Arnold, Frances H. +7 more
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Specific Adhesion of Membranes Simultaneously Supports Dual Heterogeneities in Lipids and Proteins [PDF]
, 2015 Membrane adhesion is a vital component of many biological processes. Heterogeneities in lipid and protein composition are often associated with the adhesion site. These heterogeneities are thought to play functional roles in facilitating signalling. Here
Gordon, Vernita D. +3 more
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The emerging role of the first 17 amino acids of huntingtin in Huntington’s disease
Biomolecular Concepts, 2015 Huntington’s disease (HD) is caused by a polyglutamine (polyQ) domain that is expanded beyond a critical threshold near the N-terminus of the huntingtin (htt) protein, directly leading to htt aggregation. While full-length htt is a large (on the order of
Arndt James R. +2 more
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Journal of Lipid Research, 2005 Apolipoprotein A-IMilano (A-IM) (R173C), a natural mutant of human apolipoprotein A-I (apoA-I), and five other cysteine variants of apoA-I at residues 52 (S52C), 74 (N74C), 107 (K107C), 129 (G129C), and 195 (K195C) were generated.
Xuewei Zhu +4 more
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Viruses, 2020 Marburg virus (MARV) is a lipid-enveloped negative sense single stranded RNA virus, which can cause a deadly hemorrhagic fever. MARV encodes seven proteins, including VP40 (mVP40), a matrix protein that interacts with the cytoplasmic leaflet of the host ...
Kaveesha J. Wijesinghe +7 more
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