Results 21 to 30 of about 2,675,614 (299)

Lipids and lipid binding proteins: A perfect match [PDF]

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2015
Lipids serve a great variety of functions, ranging from structural components of biological membranes to signaling molecules affecting various cellular functions. Several of these functions are related to the unique physico-chemical properties shared by all lipid species, i.e., their hydrophobicity.
openaire   +3 more sources

Unfolding and refolding of cytochrome c driven by the interaction with lipid micelles [PDF]

, 2000
Binding of native cyt c to L-PG micelles leads to a partially unfolded conformation of cyt c. This micelle-bound state has no stable tertiary structure, but remains as -helical as native cyt c in solution.
Sanghera, Narinder, Pinheiro, Teresa J. T.   +1 more
core   +1 more source

The emerging role of the first 17 amino acids of huntingtin in Huntington’s disease

Biomolecular Concepts, 2015
Huntington’s disease (HD) is caused by a polyglutamine (polyQ) domain that is expanded beyond a critical threshold near the N-terminus of the huntingtin (htt) protein, directly leading to htt aggregation. While full-length htt is a large (on the order of
Arndt James R., Chaibva Maxmore, Legleiter Justin   +2 more
doaj   +1 more source

The molecular basis of ceramide-1-phosphate recognition by C2 domains[S]

Journal of Lipid Research, 2013
Group IVA cytosolic phospholipase A2 (cPLA2α), which harbors an N-terminal lipid binding C2 domain and a C-terminal lipase domain, produces arachidonic acid from the sn-2 position of zwitterionic lipids such as phosphatidylcholine. The C2 domain has been
Katherine E. Ward, Nitin Bhardwaj, Mohsin Vora, Charles E. Chalfant, Hui Lu, Robert V. Stahelin   +5 more
doaj   +1 more source

Lipid membrane binding of NK‐lysin [PDF]

FEBS Letters, 1998
The membrane‐binding properties and pore‐forming potential of the tumor‐lysing and antibacterial polypeptide NK‐lysin were investigated. Fluorescence quenching experiments show a drastic change of accessibility to Trp58 in solution and in association with a lipid membrane.
Ruysschaert, Jean Marie, Goormaghtigh, Erik, Homblé, Fabrice, Andersson, M, Liepinsh, E, Otting, G   +5 more
openaire   +2 more sources

Solution structure of a repeated unit of the ABA-1 nematode polyprotein allergen of ascaris reveals a novel fold and two discrete lipid-binding sites [PDF]

, 2011
Parasitic nematode worms cause serious health problems in humans and other animals. They can induce allergic-type immune responses, which can be harmful but may at the same time protect against the infections. Allergens are proteins that trigger allergic
Ball, G., Smith, B.O., Cooper, Alan, Bromek Krystyna, Malcolm W Kennedy, Smith Brian O., Meenan, N.A.G., Bromek, K., Uhrín, D., Uhrin, Dusan, Cooper Alan, Brian O. Smith, Meenan, N., Krystyna Bromek, Bromek, Krystyna, Kennedy, M.W., Ball Graeme, Brian O Smith, Meenan, Nicola A. G., Alan Cooper, Uhrín Dušan, Cooper, A., Kennedy, M., Nicola A. G. Meenan, Malcolm W. Kennedy, Graeme Ball, Nicola A G Meenan, Kennedy, Malcolm W., Meenan Nicola A. G., Dušan Uhrín, Ball, Graeme, Kennedy Malcolm W., Smith, B., Smith, Brian O.   +33 more
core   +2 more sources

Naturally occurring variant of mouse apolipoprotein A-I alters the lipid and HDL association properties of the protein

Journal of Lipid Research, 2012
Plasma HDL levels are inversely associated with atherosclerosis. Inbred mouse strains differ in plasma HDL levels and susceptibility to atherosclerosis. Atherosclerosis-susceptible C57BL/6J mice possess plasma HDL levels 2-fold lower than atherosclerosis-
Timothy J. Sontag, Ronald Carnemolla, Tomas Vaisar, Catherine A. Reardon, Godfrey S. Getz   +4 more
doaj   +1 more source

Molecular Analysis of Membrane Targeting by the C2 Domain of the E3 Ubiquitin Ligase Smurf1

Biomolecules, 2020
SMAD ubiquitination regulatory factor 1 (Smurf1) is a Nedd4 family E3 ubiquitin ligase that regulates cell motility, polarity and TGFβ signaling. Smurf1 contains an N-terminal protein kinase C conserved 2 (C2) domain that targets cell membranes and is ...
Jordan L. Scott, Cary T. Frick, Kristen A. Johnson, Haining Liu, Sylvia S. Yong, Allyson G. Varney, Olaf Wiest, Robert V. Stahelin   +7 more
doaj   +1 more source

Goldilocks Dilemma: LPS Works Both as the Initial Target and a Barrier for the Antimicrobial Action of Cationic AMPs on E. coli

Biomolecules, 2023
Antimicrobial peptides (AMPs) are generally membrane-active compounds that physically disrupt bacterial membranes. Despite extensive research, the precise mode of action of AMPs is still a topic of great debate.
Martin Jakubec, Fredrik G. Rylandsholm, Philip Rainsford, Mitchell Silk, Maxim Bril’kov, Tone Kristoffersen, Eric Juskewitz, Johanna U. Ericson, John Sigurd M. Svendsen   +8 more
doaj   +1 more source

Melittin interaction with sulfated sugars and cell membranes [PDF]

, 2008
The presented work focused on an alternative mechanism of action of melittin on the cell membranes. The study using ITC reveals that melittin has a high affinity for several glycosaminoglycans (GAGs), i.e.
Klocek, Gabriela
core   +1 more source