Results 131 to 140 of about 1,416,231 (245)

ORP5 localizes to ER–lipid droplet contacts and regulates the level of PI(4)P on lipid droplets

Journal of Cell Biology, 2019
Lipid droplets (LDs) are important organelles for cell metabolism. Here, Du et al. show that phosphatidylinositol-4-phosphate produced by PI4K2A can exist on LDs and is used/consumed by ORP5, which localizes to ER–LD contacts during the growth of LDs.
Ximing Du, Linkang Zhou, Y. Aw, Hoi Yin Mak, Yanqing Xu, J. Rae, Wenmin Wang, Armella Zadoorian, Sarah E. Hancock, B. Osborne, Xiang Chen, Jia-wei Wu, N. Turner, R. Parton, Peng Li, Hongyuan Yang   +15 more
semanticscholar   +1 more source

Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation

Journal of Cell Biology, 2018
Functional heterogeneity within the lipid droplet (LD) pool of a single cell has been observed, yet the underlying mechanisms remain enigmatic. Here, we report on identification of a specialized LD subpopulation characterized by a unique proteome and a ...
Michal Eisenberg-Bord, M. Mari, Uri Weill, E. Rosenfeld-Gur, Ofer Moldavski, I. Castro, Krishnakant G. Soni, Nofar Harpaz, T. Levine, A. Futerman, F. Reggiori, V. Bankaitis, M. Schuldiner, Maria Bohnert   +13 more
semanticscholar   +1 more source

Caveolin, Cholesterol, and Lipid Droplets? [PDF]

The Journal of Cell Biology, 2001
Caveolins constitute the coat of caveolae, specialized domains of the plasma membrane. A large body of evidence suggests that caveolae are enriched in sphingolipids and cholesterol. Besides a role in signal transduction and in the sorting of membrane components, a diverse range of functions has been assigned to the caveolins in the cellular homeostasis
openaire   +4 more sources

Modulation of Physicochemical Characteristics of Pickering Emulsions: Utilization of Nanocellulose- and Nanochitin-coated Lipid Droplet Blends.

Journal of Agricultural and Food Chemistry, 2019
Mixed Pickering emulsions were prepared by blending anionic nanocellulose-stabilized lipid droplets with cationic nanochitin-stabilized lipid droplets.
Hualu Zhou, Shanshan Lv, Jinning Liu, Yunbing Tan, Jorge L. Muriel Mundo, Long Bai, O. Rojas, D. Mcclements   +7 more
semanticscholar   +1 more source

Inhibition of lipid droplet formation by Ser/Thr protein phosphatase PPM1D inhibitor, SL-176.

PLoS ONE, 2019
Obesity is a worldwide public health problem, which is associated with various severe diseases including diabetes, hypertension, atherosclerosis, and cancer. Recent studies have revealed that combination treatment of several different compounds using low
Rui Kamada, Nozomi Kimura, Fumihiko Yoshimura, Keiji Tanino, Kazuyasu Sakaguchi   +4 more
doaj   +1 more source

Seipin governs phosphatidic acid homeostasis at the inner nuclear membrane

Nature Communications
The nuclear envelope is a specialized subdomain of the endoplasmic reticulum and comprises the inner and outer nuclear membranes. Despite the crucial role of the inner nuclear membrane in genome regulation, its lipid metabolism remains poorly understood.
Anete Romanauska, Edvinas Stankunas, Maya Schuldiner, Alwin Köhler   +3 more
doaj   +1 more source

Spectral tracing of deuterium for imaging glucose metabolism. [PDF]

, 2019
Cells and tissues often display pronounced spatial and dynamical metabolic heterogeneity. Common glucose-imaging techniques report glucose uptake or catabolism activity, yet do not trace the functional utilization of glucose-derived anabolic products ...
Liu, Yinong, Miao, Yupeng, Min, Wei, Qian, Naixin, Shen, Yihui, Shi, Lingyan, Wei, Mian, Zhang, Luyuan   +7 more
core  

Lipid droplets meet aging

Aging, 2021
Felder, Thomas, Geltinger, Florian, Rinnerthaler, Mark   +2 more
openaire   +2 more sources

Opn3 Drives Blue-Light-Induced Reduction in Lipid Droplets and Antiviral Defense

Biomolecules
Abnormal lipid metabolism is a key feature of many diseases. Therefore, investigating its underlying mechanisms is of great importance. Recently, blue light has shown promise as a drug-free way to influence energy metabolism, relying on the light ...
Qifan Wu, Huiping Liu, Hongcui Liang, Xinyi Jiang, Yingqiao Qin, Shaomei Liang, Jingjing Wang, Kunpeng Liu   +7 more
doaj   +1 more source

Lipid Droplet Surface Promotes 3D Morphological Evolution of Non‐Rhomboidal Cholesterol Crystals

Advanced Science
Cholesterol crystals, which cause inflammation and various diseases, predominantly grow in a platy, rhomboid structure on the plasma membranes but exhibit an uneven three‐dimensional (3D) architecture intracellularly.
Hyun‐Ro Lee, Seunghan Kang, Siyoung Q. Choi   +2 more
doaj   +1 more source