Results 91 to 100 of about 1,446,619 (399)

Two Types of Contact Between Lipid Droplets and Mitochondria

Frontiers in Cell and Developmental Biology, 2020
Lipid droplets (LDs) and mitochondria are essential organelles involved in cellular lipid metabolism and energy homeostasis. Accumulated studies have revealed that the physical contact between these two organelles is important for their functions ...
Liujuan Cui, Pingsheng Liu
semanticscholar   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Lipid droplets and lipotoxicity during autophagy. [PDF]

, 2017
Lipid droplets (LDs) are neutral lipid storage organelles that provide a rapidly accessible source of fatty acids (FAs) for energy during periods of nutrient deprivation.
Nguyen, Truc, Olzmann, James
core   +2 more sources

Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness. [PDF]

, 2020
Antibody-mediated immune responses rely on antigen recognition by the B cell antigen receptor (BCR) and the proper engagement of its intracellular signal effector proteins.
Becker, S., Bhatt, A., Engelke, M., Erdmann, P., Griesinger, C., Hou, Z., Maier, J., Pirkuliyeva, S., Plitzko, J., Wienands, J., Wong, L.   +10 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Thematic review series: Adipocyte Biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis

Journal of Lipid Research, 2007
The majority of eukaryotic cells synthesize neutral lipids and package them into cytosolic lipid droplets. In vertebrates, triacylglycerol-rich lipid droplets of adipocytes provide a major energy storage depot for the body, whereas cholesteryl ester-rich
Dawn L. Brasaemle
doaj   +1 more source

Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue [PDF]

, 2007
In response to cold, norepinephrine (NE)-induced triacylglycerol hydrolysis (lipolysis) in adipocytes of brown adipose tissue (BAT) provides fatty acid substrates to mitochondria for heat generation (adaptive thermogenesis).
Bianco, Antonio C., Christoffolete, Marcelo A., D'Eon, Tara M., Greenberg, Andrew S., Imachi, Hitomi, Miyoshi, Hideaki, Obin, Martin S., Perfield, James W., II, Ribeiro, Miriam O., Rogers, Nicole H., Souza, Sandra C., Stancheva, Zlatina S., Strissel, Katherine J.   +12 more
core   +1 more source

Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

Nature Communications, 2020
Lipid droplets (LDs) are key subcellular organelles for regulating lipid metabolism. Although several subcellular organelles participate in lipid metabolism, it remains elusive whether physical contacts between subcellular organelles and LDs might be ...
Jinuk Kong, Yul Ji, Yong Geun Jeon, Ji Seul Han, K. H. Han, J. H. Lee, Gung Lee, H. Jang, S. S. Choe, M. Baes, J. B. Kim   +10 more
semanticscholar   +1 more source

Expanding roles for lipid droplets [PDF]

Trends in Endocrinology & Metabolism, 2011
This work was supported by grants from the American Diabetes Association, NIH RO1-DK-082574, and the U.S. Department of Agriculture, Agricultural Research Service, under agreement No. 58-1950-7-70 to ASG. This work was also supported by grants from the NIH RO1-DK59935 and RO1 DK56598 to RAC.
Andrew S, Greenberg, Rosalind A, Coleman
openaire   +2 more sources