Results 61 to 70 of about 1,446,619 (399)
Nature Communications, 2020 Acidosis, a common characteristic of the tumor microenvironment, is associated with alterations in metabolic preferences of cancer cells and progression of the disease. Here we identify the TGF-β2 isoform at the interface between these observations.
C. Corbet +13 more
semanticscholar +1 more source
Lipid Droplets and Cellular Lipid Metabolism [PDF]
Annual Review of Biochemistry, 2012 Among organelles, lipid droplets (LDs) uniquely constitute a hydrophobic phase in the aqueous environment of the cytosol. Their hydrophobic core of neutral lipids stores metabolic energy and membrane components, making LDs hubs for lipid metabolism. In addition, LDs are implicated in a number of other cellular functions, ranging from protein storage ...
Tobias C, Walther, Robert V, Farese
openaire +2 more sources
Journal of Lipid Research, 2009 15(S)-lipoxygenase-1 (15-LO-1) was present in the whole-cell homogenate of an acute human monocytic leukemia cell line (THP-1). Additionally, 15-LO-1 was detected on neutral lipid droplets isolated from THP-1 foam cells.
Ginny L. Weibel +5 more
doaj +1 more source
An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish
eLife, 2021 Lipid droplets are lipid storage organelles found in nearly all cell types from adipocytes to cancer cells. Although increasingly implicated in disease, current methods to study lipid droplets in vertebrate models rely on static imaging or the use of ...
Dianne Lumaquin +6 more
doaj +1 more source
Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators
bioRxiv, 2020 Viruses are obligate intracellular parasites that make use of the host metabolic machineries to meet their biosynthetic needs, identifying the host pathways essential for the virus replication may lead to potential targets for therapeutic intervention ...
Suelen da Silva Gomes Dias +17 more
semanticscholar +1 more source
Scientific Reports, 2022 We report the utilization of Third-Harmonic Generation microscopy for label-free live cell imaging of lipid droplets in the hypha of filamentous fungus Phycomyces blakesleeanus.
Tanja Pajić +6 more
doaj +1 more source
Folia Histochemica et Cytobiologica, 2022 INTRODUCTION: With cellular lipid storage varying, the balance between lipid intake and lipid degradation was a must to keep healthy and determined the level of lipid droplets. Although lipid droplets accumulation had been well demonstrated in adipocytes,
Xia Yi +6 more
doaj +1 more source
Lipid droplets as ubiquitous fat storage organelles in
BMC Cell Biology, 2010 Background Lipid droplets are a class of eukaryotic cell organelles for storage of neutral fat such as triacylglycerol (TAG) and cholesterol ester (CE).
Guo Fengli +3 more
doaj +1 more source
Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis. [PDF]
, 2017 Glucocorticoids promote lipolysis in white adipose tissue (WAT) to adapt to energy demands under stress, whereas superfluous lipolysis causes metabolic disorders, including dyslipidemia and hepatic steatosis. Glucocorticoid-induced lipolysis requires the
Broughton, Augusta E +6 more
core +1 more source
Lipid droplets in the nervous system: involvement in cell metabolic homeostasis
Neural Regeneration ResearchLipid droplets serve as primary storage organelles for neutral lipids in neurons, glial cells, and other cells in the nervous system. Lipid droplet formation begins with the synthesis of neutral lipids in the endoplasmic reticulum.
Yuchen Zhang +5 more
doaj +1 more source