Results 81 to 90 of about 1,446,619 (399)
Direct lysosome-based autophagy of lipid droplets in hepatocytes
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Lipid droplets (LDs) are specialized fat-storage organelles that can be used as a fuel source by many types of cells when nutrients are scarce. One mechanism used by hepatocytes (the functional cells of the liver) for the catabolism of these
Ryan J. Schulze +6 more
semanticscholar +1 more source
Current Opinion in Cell Biology, 2019 Lipid droplets (LDs) store neutral lipids in their core as an energy source when nutrients are scarce. The center of an LD is hydrophobic, and hence it is surrounded by a phospholipid monolayer, unlike other organelles that have an aqueous interior and are bounded by a phospholipid bilayer.
openaire +3 more sources
The Gregarious Lipid Droplet [PDF]
Journal of Biological Chemistry, 2008 Cytoplasmic lipid droplets were considered until recently to be in the same category as glycogen granules, simple storage sites for energy, waxing and waning as metabolic energy needs dictated, but otherwise inert particles. It has become clear, however, that droplets are much more than isolated storage depots in the cell and that they can skate around
openaire +2 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Triglyceride depletion in THP-1 cells alters cholesteryl ester physical state and cholesterol efflux
Journal of Lipid Research, 2002 To study macrophage lipid droplet composition and the effects of TG on cholesteryl ester (CE) physical state, hydrolysis, and cholesterol efflux, a technique was developed to remove the majority of accumulated TG with minimal effect on CE content.
Aaron T. Lada +2 more
doaj +1 more source
PLoS Biology, 2021 Obesity-related renal lipotoxicity and chronic kidney disease (CKD) are prevalent pathologies with complex aetiologies. One hallmark of renal lipotoxicity is the ectopic accumulation of lipid droplets in kidney podocytes and in proximal tubule cells ...
Aleksandra Lubojemska +8 more
doaj +1 more source
Lipid coated liquid crystal droplets for the on-chip detection of antimicrobial peptides [PDF]
, 2019 We describe a novel biosensor based on phospholipid-coated nematic liquid crystal (LC) droplets and demonstrate the detection of Smp43, a model antimicrobial peptide (AMP) from the venom of North African scorpion Scorpio maurus palmatus.
Bao, Peng +9 more
core +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
The Phospholipid:Diacylglycerol Acyltransferase Lro1 Is Responsible for Hepatitis C Virus Core-Induced Lipid Droplet Formation in a Yeast Model System. [PDF]
PLoS ONE, 2016 Chronic infection with the hepatitis C virus frequently induces steatosis, which is a significant risk factor for liver pathogenesis. Steatosis is characterized by the accumulation of lipid droplets in hepatocytes.
Shingo Iwasa +7 more
doaj +1 more source
Ferritin in the fungus Phycomyces [PDF]
, 1971 The iron-protein ferritin has been purified from mycelium, sporangiophores, and spores of the fungus Phycomyces blakesleeanus. It has a protein-to-iron ratio of 5, a sedimentation coefficient of 55S, a buoyant density in CsCl of 1.82 g/cm3, and the ...
David, Charles N., Easterbrook, Kenneth
core +4 more sources