Results 91 to 100 of about 926,787 (298)
Lipid-mediated preferential localization of hypericin in lipid membranes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2009 Subcellular localization of a photosensitizer is critical to its therapeutic outcome during photodynamic therapy (PDT). We delineated the distribution of hypericin, a new generation photosensitizer, in model membrane systems to identify the operating principles of its subcellular accumulation. Results from fluorescence microscopy indicated preferential
Ho, Yunn-Fang +4 more
openaire +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Lipid Content in the Sea Urchin Embryos under Nickel Stress
, 2009 Nickel is a heavy metal toxic for living organisms even at low concentrations. Sea urchin embryos represent a good model system for testing the effects of physical and chemical stress, like heavy metals, on development and cell viability.
황진익 +3 more
core
Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes. [PDF]
, 2019 Individuals with concurrent tuberculosis (TB) and Type 2 diabetes (DM) have a higher risk of adverse outcomes. To better understand potential immunological differences, we utilized a comprehensive panel to characterize pro-inflammatory and pro-resolving (
Lokhande, R +27 more
core +1 more source
Microbiota and lipid mediators: from molecular crosstalk to therapeutic opportunities
Frontiers in PharmacologyThe gut microbiota constitutes a metabolically active ecosystem that dynamically interacts with the host lipid metabolism and cellular signaling networks.
Büşra Başar Gökcen +10 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Lipid composition of gluten-free wafer snack present in the Italian market
, 2015 Celiac disease, a pathology related to intolerance at gliadin fraction of wheat and the prolamin that leads to small intestine inflammation with malabsorption of some nutrients (such as folic acid, calcium, iron and fat-soluble vitamins), has widely ...
CARDENIA, VLADIMIRO +2 more
core +1 more source
Lipid Mediator Informatics and Proteomics in Inflammation-Resolution
The Scientific World Journal, 2006 Lipid mediator informatics is an emerging area denoted to the identification of bioactive lipid mediators (LMs) and their biosynthetic profiles and pathways.
Yan Lu +3 more
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source