Results 81 to 90 of about 926,787 (298)

Mechanisms of leukocyte lipid body formation and function in inflammation

Memorias do Instituto Oswaldo Cruz, 2005
An area of increasingly interest for the understanding of cell signaling are the spatio-temporal aspects of the different enzymes involved in lipid mediator generation (eicosanoid-forming enzymes, phospholipases and their regulatory kinases and ...
Patrícia T Bozza, Christianne Bandeira-Melo   +1 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Effects of stimulation technique, anatomical region, and time on human sweat lipid mediator profiles [PDF]

, 2018
Few studies compare sampling protocol effect on sweat composition. Here we evaluate the impact of sweat stimulation mode and site of collection on lipid mediator composition.
Karan Agrawal, Justin D. Waller, Newman, John W, Theresa L. Pedersen, John W. Newman, Pedersen, Theresa L, Waller, Justin D, Agrawal, Karan   +7 more
core   +1 more source

A case series of the dynamics of lipid mediators in patients with sepsis

Acute Medicine & Surgery, 2019
Background Bioactive lipid mediators play a crucial role during infection. Previously, we showed the expression level of FAAH mRNA in septic patients was lower than in healthy controls.
Mitsuhide Hamaguchi, Heng Ning Wu, Masahiro Tanaka, Noriko Tsuda, Ourlad Alzeus Gaddi Tantengco, Tomohide Matsushima, Takami Nakao, Takuya Ishibe, Ikuhiro Sakata, Itaru Yanagihara   +9 more
doaj   +1 more source

Updating Phospholipase A₂ Biology

Biomolecules, 2020
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that are subdivided into several distinct families on a structural and biochemical basis.
Makoto Murakami, Hiroyasu Sato, Yoshitaka Taketomi   +2 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Chilling injury mechanism in the immature oocytes of zebrafish (Danio rerio)

The Journal of Reproduction and Development
Immature zebrafish oocytes are sensitive to chilling, and their survival is markedly reduced by exposure to 0°C. In the present study, we investigated the involvement of cold-sensitive channels and lipid mediators in chilling injury in immature zebrafish ...
Yanuar ACHADRI, Shino SONODA, Saki OKUBO, Kazutsugu MATSUKAWA, Keisuke EDASHIGE   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Structure of the MED7/MED21 heterodimer and reconstitution of a recombinant Mediator middle module complex [PDF]

, 2005
The Mediator of transcriptional regulation is the central coactivator that enables a response of RNA polymerase II (Pol II) to activators and repressors.
Baumli, Sonja
core   +1 more source

Lipid Mediators in Life Science

Experimental Animals, 2011
"Lipid mediators" represent a class of bioactive lipids that are produced locally through specific biosynthetic pathways in response to extracellular stimuli. They are exported extracellularly, bind to their cognate G protein-coupled receptors (GPCRs) to transmit signals to target cells, and are then sequestered rapidly through specific enzymatic or ...
openaire   +3 more sources