Results 101 to 110 of about 926,787 (298)

Lipid peroxidation is essential for α-synuclein-induced cell death. [PDF]

, 2015
Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease.
Klenerman, D, Shchepinov, MS, Gandhi, S, Angelova, PR, Horrocks, MH, Abramov, AY   +5 more
core  

Elevated levels of erythrocyte-conjugated dienes indicate increased lipid peroxidation in schistosomiasis mansoni patients [PDF]

, 2004
Schistosoma mansoni causes liver disease by inducing granulomatous inflammation. This favors formation of reactive oxygen species, including superoxide ions, hydrogen peroxide and hydroxyl radicals all of which may induce lipid peroxidation.
Owen, JS, Brandt, CT, Facundo, HT, Facundo, H.T.F., V.L.M. Lima, Lima, V.L.M., Lima, VL, J.S. Owen, Brandt, C.T., C.T. Brandt, H.T.F. Facundo, Owen, J.S.   +11 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Effects of atopic dermatitis and gender on sebum lipid mediator and fatty acid profiles [PDF]

, 2018
Skin disease alters cutaneous lipid mediator metabolism, and if skin secretions contain evidence of these changes, they may constitute useful clinical matrices with low associated subject burden.
Karan Agrawal, Lauren A. Hassoun, Kamil Borkowski, Theresa L. Pedersen, John W. Newman, Borkowski, Kamil, Negar Foolad, Foolad, Negar, Raja K. Sivamani, Sivamani, Raja K, Newman, John W, Pedersen, Theresa L, Hassoun, Lauren A, Agrawal, Karan   +13 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Lipid emulsion rich in n-3 polyunsaturated fatty acids elicits a pro-resolution lipid mediator profile in mouse tissues and in human immune cells

, 2022
BACKGROUND Lipid emulsions are a key component of total parenteral nutrition (TPN) and are administered to patients who are unable to ingest their daily required calories orally.
Hartling, Ivan; https://orcid.org/, Wawrzyniak, Paulina; https://orcid.org/, Lou, Phing-How; https://orcid.org/, Srikanthan, Pakeerathan, Rogler, Gerhard; https://orcid.org/, Lucchinetti, Eliana; https://orcid.org/, Zaugg, Michael; https://orcid.org/, Noureddine, Nazek; https://orcid.org/, Krämer, Stefanie D; https://orcid.org/, Hersberger, Martin; https://orcid.org/   +9 more
core   +1 more source

Regulation and Functions of 15-Lipoxygenases in Human Macrophages

Frontiers in Pharmacology, 2019
Lipoxygenases (LOXs) catalyze the stereo-specific peroxidation of polyunsaturated fatty acids (PUFAs) to their corresponding hydroperoxy derivatives. Human macrophages express two arachidonic acid (AA) 15-lipoxygenating enzymes classified as ALOX15 and ...
Ryan G. Snodgrass, Bernhard Brüne
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source