Results 91 to 100 of about 333,930 (355)

Treatment With a Marine Oil Supplement Alters Lipid Mediators and Leukocyte Phenotype in Healthy Patients and Those With Peripheral Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Peripheral artery disease (PAD) is an advanced form of atherosclerosis characterized by chronic inflammation. Resolution of inflammation is a highly coordinated process driven by specialized pro‐resolving lipid mediators endogenously derived ...
Melinda S. Schaller, Mian Chen, Romain A. Colas, Thomas A. Sorrentino, Ann A. Lazar, S. Marlene Grenon, Jesmond Dalli, Michael S. Conte   +7 more
doaj   +1 more source

A Retrospective Cohort Study Comparing Stroke Recurrence Rate in Ischemic Stroke Patients With and Without Acupuncture Treatment. [PDF]

, 2015
Little was known about the effects of acupuncture on stroke recurrence. The aim of this study is to investigate whether ischemic stroke patients receiving acupuncture treatment have a decreased risk of stroke recurrence.
Hsu, Chung Y, Liao, Chien-Chang, Lin, Jaung-Geng, Morisky, Donald E, Shih, Chun-Chuan, Su, Yi-Chang, Sun, Mao-Feng, Sung, Fung-Chang, Wen, Chi-Pang   +8 more
core   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

THEM6-mediated lipid remodelling sustains stress resistance in cancer [PDF]

, 2021
Arnaud Blomme, Coralie Peter, Ernest Mui, Giovanny Rodriguez Blanco, Louise M. Mason, Lauren E. Jamieson, Grace H. McGregor, Sérgio Lilla, Chara Ntala, Rachana Patel, Marc Thiry, Sonia H.Y. Kung, Catriona A. Ford, Linda Rushworth, David J. McGarry, Susan Mason, Peter Repiščák, Colin Nixon, Mark J. Salji, Elke Markert, Gillian Mackay, Jurre J. Kamphorst, Duncan Graham, Karen Faulds, Ladan Fazli, Martin Gleave, Edward Avezov, Joanne Edwards, Huabing Yin, David Sumpton, Karen Blyth, Pierre Close, Daniel J. Murphy, Sara Zanivan, Hing Y. Leung   +34 more
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Editorial: Quo Vadis Lipid Mediators – Lipid Mediators Implication in Inflammation and Chronic Inflammatory Diseases

Frontiers in Immunology, 2021
Danuta Radzioch, Martin Giera, Juan Bautista De Sanctis   +2 more
doaj   +1 more source

Nuclear receptors in vascular biology [PDF]

, 2015
Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla, A McCurley, AA Hamers, AL Bookout, B Fisslthaler, BG Hoebel, C McCarthy, C Zhou, CH Lee, CK Glass, CK Huang, CT Lee, D Bishop-Bailey, D Bishop-Bailey, David Bishop-Bailey, DP Edwards, E Gerlach, F Akbiyik, FA Pereira, FL Wynne, FY Ali, G Pascual, I Dussault, I Spoletini, J He, J Qin, J Sonoda, J Xiang, K Spruiell, KE Swales, L Calza, L Li, L Piqueras, LA Moraes, LA Moraes, LJ Jonk, LR You, M Kaushik, M Matic, N Albermann, N Schafer, N Takamoto, Q Qin, R Zhao, S Asgary, S Chakrabarti, S Marino De, S Stein, SA Kliewer, V Zoete, W El-Sankary, WC Lau, X Wang, Y Ma, Y Sui, Y Sui, YW Hu   +56 more
core   +3 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Vesicular trafficking and signaling for cytokine and chemokine secretion in mast cells

Frontiers in Immunology, 2014
Upon activation mast cells (MC) secrete numerous inflammatory compounds stored in their cytoplasmic secretory granules (SG) by a process called anaphylactic degranulation, which is responsible for type I hypersensitivity responses.
Ulrich eBlank, Ulrich eBlank, Ulrich eBlank, Iris Karina Madera-Salcedo, Iris Karina Madera-Salcedo, Iris Karina Madera-Salcedo, Luca eDanelli, Luca eDanelli, Luca eDanelli, Julien eClaver, Julien eClaver, Julien eClaver, Neeraj eTiwari, Neeraj eTiwari, Neeraj eTiwari, Elizabeth eSánchez-Miranda, Genaro eVázquez-Victorio, Karla Alina eRamírez-Valadez, Marina eMacias-Silva, Claudia eGonzález-Espinosa   +19 more
doaj   +1 more source