Results 61 to 70 of about 103,596 (298)

A neuronal relay mediates a nutrient responsive gut/fat body axis regulating energy homeostasis in adult Drosophila [PDF]

, 2019
The control of systemic metabolic homeostasis involves complex inter-tissue programs that coordinate energy production, storage, and consumption, to maintain organismal fitness upon environmental challenges.
Bauer, Christin, Cordero, Julia B., Kruspig, Bjorn, Maddocks, Oliver D.K., Murphy, Daniel J., Scopelliti, Alessandro, Vidal, Marcos, Yu, Yachuan, Zhang, Tong   +8 more
core   +1 more source

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Effects of Body Condition and Concentrate Proportion of the Ration on Mobilization of Fat Depots and Energetic Condition in Dairy Cows during Early Lactation Based on Ultrasonic Measurements

Animals, 2019
The aim of this study was to evaluate energy metabolism and lipid mobilization via ultrasonic measurements (USM), considering inner fat depots, in lactating dairy cows differing in body condition score (BCS) and fed rations with low (35% at dry matter ...
Katharina Bünemann, Dirk von Soosten, Jana Frahm, Susanne Kersten, Ulrich Meyer, Jürgen Hummel, Annette Zeyner, Sven Dänicke   +7 more
doaj   +1 more source

Circulating free fatty acids, insulin, and glucose during chemical stimulation of hypothalamus in rats [PDF]

, 1984
The aim of this study was to investigate plasma free fatty acids (FFA), insulin, and blood glucose during chemical stimulation of the lateral and ventromedial hypothalamic areas (LHA and VMH) in rats.
Damsma, G.,, Gugten, J. van der,, Luiten, P.G.M.,, Steffens, A.B.,   +3 more
core   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Microsomal membrane-associated apoB is the direct precursor of secreted VLDL in primary cultures of rat hepatocytes

Journal of Lipid Research, 2001
Brefeldin A (BFA) added to primary cultures of rat hepatocytes, at a concentration of 0.2 μg/ml, prevented the assembly of newly synthesized apolipoprotein B (apoB) into mature, secretory VLDL but did not prevent the secretion of apoB as denser particles
Abdel-Malek Hebbachi, Geoffrey F. Gibbons   +1 more
doaj   +1 more source

Biogenesis and Lipase-Mediated Mobilization of Lipid Droplets in Plants

Plants, 2022
Cytosolic lipid droplets (LDs) derived from the endoplasmic reticulum (ER) mainly contain neutral lipids, such as triacylglycerols (TAGs) and sterol esters, which are considered energy reserves.
Yun Ju Choi, Kseniia Zaikova, Soo-Jin Yeom, Yeong-Su Kim, Dong Wook Lee   +4 more
doaj   +1 more source

Identification of Giardia lamblia DHHC Proteins and the Role of Protein S-palmitoylation in the Encystation Process [PDF]

, 2014
Protein S-palmitoylation, a hydrophobic post-translational modification, is performed by protein acyltransferases that have a common DHHC Cys-rich domain (DHHC proteins), and provides a regulatory switch for protein membrane association. In this work, we
A Criscuolo, A Hiltpold, A Krogh, AB Hehl, AF Roth, AF Roth, AI Magee, Andrea S. Rópolo, B Eisenhaber, BC Jennings, BJ Davids, BJ Davids, BR Martin, BT Emmer, C Aicart-Ramos, C Aurrecoechea, C Faso, C Notredame, C Salaun, Cecilia V. Vranych, CH Sun, CH Sun, CH Wang, D Lloyd, DA Mitchell, DA Mitchell, DB Keister, DJ Bartels, DS Reiner, DS Reiner, EG Politis, F Abascal, FD Gillin, G DeJesus, GE Tusnady, GE Tusnady, HD Lujan, HD Lujan, HG Elmendorf, HG Morrison, I Letunic, I Letunic, I Slavin, J Greaves, J Greaves, J Greaves, J Pei, J Ren, J Schindelin, J Schultz, J Wan, J Yee, JA Duncan, JE Smotrys, JO Ebinu, JR Beck, JT Dunphy, K Frenal, KB Nicholas, KJ Livak, L Morf, LH Su, M Anisimova, M Fukata, M Punta, M Saric, María C. Merino, María C. Touz, MC Touz, MC Touz, MC Touz, MC Touz, MD Resh, ME Linder, ME Linder, MG De Napoli, ML Jones, ML Jones, MM Corvi, MM Zhang, MR Rivero, MS Brown, N Gottig, Nahuel Zamponi, O Batistic, O Rocks, P Papanastasiou, PG Carranza, R Tsutsumi, RD Adam, RD Finn, S Guindon, S Lobo, S Sonda, S Stoven, SE Boucher, SF Chuang, SL Planey, SM Singer, SR Birkeland, Steven M. Singer, T Hoppe, T Lauwaet, TE Nash, TE Nash, TN Petersen, TS Worgall, WF Leong, Y Fukata, Y He, Y Huang, Y Ohno, Y Webb, YC Huang, YJ Pan   +114 more
core   +3 more sources

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source