Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery [PDF]
, 2020 Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD).
Huang, Hui +3 more
core +2 more sources
Lipid-Polyglutamate Nanoparticle Vaccine Platform
ACS Applied Materials & Interfaces, 2021 Peptide-based subunit vaccines are attractive in view of personalized cancer vaccination with neo-antigens, as well as for the design of the newest generation of vaccines against infectious diseases. Key to mounting robust antigen-specific immunity is delivery of antigen to antigen-presenting (innate immune) cells in lymphoid tissue with concomitant ...
Dorien Van Lysebetten +17 more
openaire +8 more sources
A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems
Nature Communications, 2021 Lipid nanoparticle delivery of mRNA vaccines has become of particular importance, however, mRNA stability is a major concern. Here, the authors report on a study of lipid impurity mRNA interactions using reverse phase ion pair HPLC to identify reactions ...
Meredith Packer +4 more
doaj +1 more source
Biophysical analysis of lipidic nanoparticles [PDF]
Methods, 2020 Biological nanoparticles include liposomes, extracellular vesicle and lipid-based discoidal systems. When studying such particles, there are several key parameters of interest, including particle size and concentration. Measuring these characteristics can be of particular importance in the research laboratory or when producing such particles as ...
Rozo, Annaïg J. +4 more
openaire +2 more sources
Nanoparticles in the treatment of chronic lung diseases [PDF]
, 2019 Nanoparticles, although considered a topic of modern medicine, actually have an interesting history. Currently, advances in nanomedicine hold great promise as drug carrier systems for sustained release and targeted delivery of diverse therapeutic agents.
Alexescu, Teodora G +9 more
core +2 more sources
Lipid Nanoparticles for Ocular Gene Delivery
Journal of Functional Biomaterials, 2015 Lipids contain hydrocarbons and are the building blocks of cells. Lipids can naturally form themselves into nano-films and nano-structures, micelles, reverse micelles, and liposomes.
Yuhong Wang +2 more
doaj +1 more source
Cholesterol-directed nanoparticle assemblies based on single amino acid peptide mutations activate cellular uptake and decrease tumor volume. [PDF]
, 2017 Peptide drugs have been difficult to translate into effective therapies due to their low in vivo stability. Here, we report a strategy to develop peptide-based therapeutic nanoparticles by screening a peptide library differing by single-site amino acid ...
Landry, Markita P +4 more
core +1 more source
mRNA lipid nanoparticle phase transition
Biophysical Journal, 2022 Crucial for mRNA-based vaccines are the composition, structure, and properties of lipid nanoparticles (LNPs) as their delivery vehicle. Using all-atom molecular dynamics simulations as a computational microscope, we provide an atomistic view of the structure of the Comirnaty vaccine LNP, its molecular organization, physicochemical properties, and ...
Trollmann, Marius F.W. +1 more
openaire +2 more sources
A correlative model to predict in vivo AUC for nanosystem drug delivery with release rate-limited absorption [PDF]
, 2012 Purpose. Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo ...
Adibkia, Khosro +6 more
core +3 more sources
Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation. [PDF]
, 2013 Nanocarriers can deliver a wide variety of drugs, target them to sites of interest, and protect them from degradation and inactivation by the body. They have the capacity to improve drug action and decrease undesirable systemic effects.
Bratt, Jennifer M +6 more
core +2 more sources