Results 41 to 50 of about 133,206 (305)
From lipids to lipid nanoparticles to mRNA vaccines [PDF]
Nature Reviews Materials, 2021 Lipid nanoparticles are essential to mRNA vaccines. The groundwork for lipid-based drug delivery systems was laid more than 40 years ago in the lab of Pieter Cullis, Professor at the University of British Columbia. Nature Reviews Materials talks to Pieter Cullis about the history and future of lipid nanoparticle-nucleic acid drugs.
openaire +2 more sources
Lipid Nanoparticle-Mediated Liver-Specific Gene Therapy for Hemophilia B
PharmaceuticsBackground/Objectives: Hemophilia B is a hereditary bleeding disorder due to the production of liver malfunctional factor IX (FIX). Gene therapy with viral vectors offers a cure.
Brijesh Lohchania +5 more
doaj +1 more source
Payload distribution and capacity of mRNA lipid nanoparticles
Nature Communications, 2022 Lipid nanoparticles (LNPs) are effective vehicles to deliver mRNA vaccines and therapeutics but assessing the mRNA packaging characteristics in LNPs is challenging.
Sixuan Li +11 more
doaj +1 more source
Export of miRNAs from activated macrophages is cooperative and HuR‐dependent
FEBS Letters, EarlyView.This study uncovers a new mechanism for miRNA export regulation in mammalian cells, driven by the RNA‐binding protein HuR. In macrophages, HuR cooperatively binds with miRNAs to export both low‐ and high‐affinity substrates, thereby influencing macrophage activation.
Syamantak Ghosh +2 more
wiley +1 more source
The role of ultrasound-driven microbubble dynamics in drug delivery : from microbubble fundamentals to clinical translation [PDF]
, 2019 In the last couple of decades, ultrasound-driven microbubbles have proven excellent candidates for local drug delivery applications. Besides being useful drug carriers, microbubbles have demonstrated the ability to enhance cell and tissue permeability ...
De Smedt, Stefaan +6 more
core +4 more sources
Tear of lipid membranes by nanoparticles
Soft Matter, 2022 Tear, a direct physical damage of lipid bilayers, can be inflicted by small enough nanoparticles.
Er-Rafik, Meriem +7 more
openaire +4 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Research Advances on the Stability of mRNA Vaccines
Viruses, 2023 Compared to other vaccines, the inherent properties of messenger RNA (mRNA) vaccines and their interaction with lipid nanoparticles make them considerably unstable throughout their life cycles, impacting their effectiveness and global accessibility.
Feiran Cheng +7 more
doaj +1 more source
2014 REU Poster: Quantifying Lipid Contents In Liposomes with Enveloped Plasmonic Nanoparticles [PDF]
, 2014 Poster presentation at REU Summer's End Research Symposium, 2014, by REU participant Beatrix Seytono, Calhoun Community College - Bjoern Reinhard group, Amin Feizpour lab mentor.Phosphatidylserine(PS) and monosialotetrahexosylganglioside(GM1) are ...
Seytono, Beatrix
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source