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Encyclopedia, 2022 Solid lipid nanoparticles (SLNs) are produced from physiologically biocompatible lipids. They have been proven to improve solubility, cellular uptake, and stability, reduce enzyme degradation, and prolong the circulation time of various drugs.
Thi-Thao-Linh Nguyen, Van-An Duong
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Lipid nanoparticles for mRNA delivery [PDF]
Nature Reviews Materials, 2021 Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent and treat various diseases. To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and mRNA release.
Xucheng Hou +2 more
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Lipid Nanoparticles for Ocular Gene Delivery [PDF]
Journal of Functional Biomaterials, 2015 Lipids contain hydrocarbons and are the building blocks of cells. Lipids can naturally form themselves into nano-films and nano-structures, micelles, reverse micelles, and liposomes.
Yuhong Wang +2 more
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Nebulized lipid nanoparticles [PDF]
Nature Reviews Materials, 2021 An article in Nature Biomedical Engineering reports an in vivo workflow for the design of lipid nanoparticles to efficiently deliver mRNA to the lungs via nebulization.
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Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review
Pharmaceutics, 2023 Solid–lipid nanoparticles and nanostructured lipid carriers are delivery systems for the delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures. These nanocarriers may enhance the solubility and permeability of drugs,
Cláudia Viegas +5 more
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Solid Lipid Nanoparticles (SLN): Formulation and Fabrication
Pharmaceutical Sciences and Research, 2023 Solid lipid nanoparticles (SLN) have emerged as a novel drug delivery system and have been utilized for delivering various kinds of drugs since the 1990s. These particles may consist of multiple solid lipids, including glycerides, waxes, and fatty acids,
Gabriella F. Punu +5 more
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Immune-Modulating Lipid Nanomaterials for the Delivery of Biopharmaceuticals
Pharmaceutics, 2023 In recent years, with the approval of preventative vaccines for pandemics, lipid nanoparticles have become a prominent RNA delivery vehicle. The lack of long-lasting effects of non-viral vectors is an advantage for infectious disease vaccines.
Songhee Kim +3 more
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Lipid Nanoparticles for Drug Delivery
Advanced NanoBiomed Research, 2022 Lipid nanoparticles have attracted significant interests in the last two decades, and have achieved tremendous clinical success since the first clinical approval of Doxil in 1995.
Letao Xu +5 more
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Advances in Lipid-Based Nanoparticles for Cancer Chemoimmunotherapy
Pharmaceutics, 2021 Nanomedicines have shown great potential in cancer therapy; in particular, the combination of chemotherapy and immunotherapy (namely chemoimmunotherapy) that is revolutionizing cancer treatment.
Tianqi Wang +5 more
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Lipid Nanoparticles Functionalized with Antibodies for Anticancer Drug Therapy
Pharmaceutics, 2023 Nanotechnology takes the lead in providing new therapeutic options for cancer patients. In the last decades, lipid-based nanoparticles—solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), liposomes, and lipid–polymer hybrid ...
Ana Camila Marques +3 more
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