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Lipid Peroxidation in Neurodegeneration [PDF]

Antioxidants, 2021
Neurodegenerative diseases have multiple social and economic impacts on society, and they are the cause of millions of deaths every year [...]
Consuelo Cháfer-Pericás
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Lipid Peroxidation and Antioxidant Protection

Biomolecules, 2023
Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological systems, owing to its interplay with ferroptosis and to its role in secondary damage to other biomolecules, such as proteins.
Luca Valgimigli
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Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications [PDF]

Cell Death and Disease
Regulated cell death (RCD) refers to the form of cell death that can be regulated by various biomacromolecules. Each cell death modalities have their distinct morphological changes and molecular mechanisms.
Yongxin Zheng, Junlu Sun, Zhiting Luo, Yimin Li, Yongbo Huang   +4 more
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Natural ingredients in the regulation of abnormal lipid peroxidation: a potential therapy for pulmonary diseases [PDF]

Frontiers in Pharmacology
Pulmonary diseases are a major category of diseases that pose a threat to human health. The most common drugs currently used to treat lung diseases are still chemical drugs, but this may lead to drug resistance and damage to healthy organs in the body ...
Yundou Liu, Chunyi Wang, Mengru Li, Yi Zhu, Ke Liu, Yufei Liu, Maocai Luo, Chuantao Zhang   +7 more
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SLC27A2 marks lipid peroxidation in nasal epithelial cells driven by type 2 inflammation in chronic rhinosinusitis with nasal polyps [PDF]

Experimental and Molecular Medicine
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent inflammation and epithelial cell dysfunction, but the underlying molecular mechanisms remain poorly understood. Here we show that dysregulated lipid metabolism and increased
Jaewoo Park, Jung Yeon Jang, Jeong Heon Kim, Se Eun Yi, Yeong Ju Lee, Myeong Sang Yu, Yoo-Sam Chung, Yong Ju Jang, Ji Heui Kim, Kyuho Kang   +9 more
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Associations between Plasma Lipid Mediators and Chronic Daily Headache Outcomes in Patients Randomized to a Low Linoleic Acid Diet with or without Added Omega-3 Fatty Acids

Metabolites, 2023
A previous report showed that 12-week lowering of dietary omega-6 linoleic acid (LA) coupled with increased omega-3 polyunsaturated fatty acid (PUFA) intake (H3-L6 diet) reduced headache frequency and improved quality of life in patients with chronic ...
Qing Shen, Jun Yang, Daisy Zamora, Mark Horowitz, Keturah R. Faurot, Beth A. MacIntosh, J. Douglas Mann, Bruce D. Hammock, Christopher E. Ramsden, Ameer Y. Taha   +9 more
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Dietary fatty acids improve perceived sleep quality, stress, and health in migraine: a secondary analysis of a randomized controlled trial

Frontiers in Pain Research, 2023
BackgroundMigraine is a prevalent disabling condition often associated with comorbid physical and psychological symptoms that contribute to impaired quality of life and disability.
Keturah R. Faurot, Jinyoung Park, Vanessa Miller, Gilson Honvoh, Anthony Domeniciello, J. Douglas Mann, Susan A. Gaylord, Chanee E. Lynch, Olafur Palsson, Christopher E. Ramsden, Christopher E. Ramsden, Beth A. MacIntosh, Mark Horowitz, Daisy Zamora, Daisy Zamora, Daisy Zamora   +15 more
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ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer’s disease

Acta Neuropathologica Communications, 2023
In sporadic Alzheimer’s disease (sAD) specific regions, layers and neurons accumulate hyperphosphorylated Tau (pTau) and degenerate early while others remain unaffected even in advanced disease.
Christopher E. Ramsden, Daisy Zamora, Mark S. Horowitz, Jahandar Jahanipour, Elizabeth Calzada, Xiufeng Li, Gregory S. Keyes, Helen C. Murray, Maurice A. Curtis, Richard M. Faull, Andrea Sedlock, Dragan Maric   +11 more
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Cell Death via Lipid Peroxidation and Protein Aggregation Diseases

Biology, 2021
Lipid peroxidation of cellular membranes is a complicated cellular event, and it is both the cause and result of various diseases, such as ischemia-reperfusion injury, neurodegenerative diseases, and atherosclerosis.
Katsuya Iuchi, Tomoka Takai, Hisashi Hisatomi   +2 more
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Interplay of Nrf2 and BACH1 in inducing ferroportin expression and enhancing resistance of human macrophages towards ferroptosis

Cell Death Discovery, 2022
Compared to cancer cells, macrophages are inert to lipid peroxidation-triggered, iron-dependent cell death known as ferroptosis. Mechanisms underlying macrophage resistance towards ferroptosis are largely obscure.
Dmitry Namgaladze, Dominik C. Fuhrmann, Bernhard Brüne   +2 more
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