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Lipid Peroxidation in Neurodegeneration [PDF]

Antioxidants, 2021
Neurodegenerative diseases have multiple social and economic impacts on society, and they are the cause of millions of deaths every year [...]
Consuelo Cháfer-Pericás
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ACSL4 at the helm of the lipid peroxidation ship: a deep-sea exploration towards ferroptosis [PDF]

Frontiers in Pharmacology
Lipid peroxidation stands as a prominent hallmark and a prerequisite for the onset of ferroptosis. Lipid metabolism holds a pivotal role in regulating this process, forming the metabolic foundation for cellular sensitivity to ferroptosis.
Yulang Jiang, Yulang Jiang, Yulang Jiang, Meng Zhang, Meng Zhang, Meng Zhang, Mingyu Sun, Mingyu Sun, Mingyu Sun   +8 more
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Endogenous Derivatives of Linoleic Acid and their Stable Analogs Are Potential Pain Mediators

JID Innovations, 2023
Psoriasis is characterized by intense pruritus, with a subset of individuals with psoriasis experiencing thermal hypersensitivity. However, the pathophysiology of thermal hypersensitivity in psoriasis and other skin conditions remains enigmatic. Linoleic
Joshua J. Wheeler, Anthony F. Domenichiello, Jennifer R. Jensen, Gregory S. Keyes, Kristen M. Maiden, John M. Davis, Christopher E. Ramsden, Santosh K. Mishra   +7 more
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Associations between Plasma Lipid Mediators and Chronic Daily Headache Outcomes in Patients Randomized to a Low Linoleic Acid Diet with or without Added Omega-3 Fatty Acids

Metabolites, 2023
A previous report showed that 12-week lowering of dietary omega-6 linoleic acid (LA) coupled with increased omega-3 polyunsaturated fatty acid (PUFA) intake (H3-L6 diet) reduced headache frequency and improved quality of life in patients with chronic ...
Qing Shen, Jun Yang, Daisy Zamora, Mark Horowitz, Keturah R. Faurot, Beth A. MacIntosh, J. Douglas Mann, Bruce D. Hammock, Christopher E. Ramsden, Ameer Y. Taha   +9 more
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Dietary fatty acids improve perceived sleep quality, stress, and health in migraine: a secondary analysis of a randomized controlled trial

Frontiers in Pain Research, 2023
BackgroundMigraine is a prevalent disabling condition often associated with comorbid physical and psychological symptoms that contribute to impaired quality of life and disability.
Keturah R. Faurot, Jinyoung Park, Vanessa Miller, Gilson Honvoh, Anthony Domeniciello, J. Douglas Mann, Susan A. Gaylord, Chanee E. Lynch, Olafur Palsson, Christopher E. Ramsden, Christopher E. Ramsden, Beth A. MacIntosh, Mark Horowitz, Daisy Zamora, Daisy Zamora, Daisy Zamora   +15 more
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ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer’s disease

Acta Neuropathologica Communications, 2023
In sporadic Alzheimer’s disease (sAD) specific regions, layers and neurons accumulate hyperphosphorylated Tau (pTau) and degenerate early while others remain unaffected even in advanced disease.
Christopher E. Ramsden, Daisy Zamora, Mark S. Horowitz, Jahandar Jahanipour, Elizabeth Calzada, Xiufeng Li, Gregory S. Keyes, Helen C. Murray, Maurice A. Curtis, Richard M. Faull, Andrea Sedlock, Dragan Maric   +11 more
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Analysis of omega-3 and omega-6 polyunsaturated fatty acid metabolism by compound-specific isotope analysis in humans

Journal of Lipid Research, 2023
Natural variations in the 13C:12C ratio (carbon-13 isotopic abundance [δ13C]) of the food supply have been used to determine the dietary origin and metabolism of fatty acids, especially in the n-3 PUFA biosynthesis pathway.
Daniel K. Chen, Adam H. Metherel, Kimia Rezaei, Camilla Parzanini, Chuck T. Chen, Christopher E. Ramsden, Mark Horowitz, Keturah R. Faurot, Beth MacIntosh, Daisy Zamora, Richard P. Bazinet   +10 more
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Cell Death via Lipid Peroxidation and Protein Aggregation Diseases

Biology, 2021
Lipid peroxidation of cellular membranes is a complicated cellular event, and it is both the cause and result of various diseases, such as ischemia-reperfusion injury, neurodegenerative diseases, and atherosclerosis.
Katsuya Iuchi, Tomoka Takai, Hisashi Hisatomi   +2 more
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Hydroxy-epoxide and keto-epoxide derivatives of linoleic acid activate trigeminal neurons

Neurobiology of Pain, 2020
Endogenous lipid mediators are proposed to contribute to headache and facial pain by activating trigeminal neurons (TN). We recently identified 11-hydroxy-epoxide- and 11-keto-epoxide derivatives of linoleic acid (LA) that are present in human skin and ...
Suzanne Doolen, Gregory S. Keyes, Christopher E. Ramsden   +2 more
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Interplay of Nrf2 and BACH1 in inducing ferroportin expression and enhancing resistance of human macrophages towards ferroptosis

Cell Death Discovery, 2022
Compared to cancer cells, macrophages are inert to lipid peroxidation-triggered, iron-dependent cell death known as ferroptosis. Mechanisms underlying macrophage resistance towards ferroptosis are largely obscure.
Dmitry Namgaladze, Dominik C. Fuhrmann, Bernhard Brüne   +2 more
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