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Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal [PDF]
Oxidative Medicine and Cellular Longevity, 2014 Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs).
Argüelles Castilla, Sandro +2 more
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Lipid Peroxidation and Antioxidant Protection
Biomolecules, 2023 Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological systems, owing to its interplay with ferroptosis and to its role in secondary damage to other biomolecules, such as proteins.
Luca Valgimigli
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Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications
Cell Death and DiseaseRegulated cell death (RCD) refers to the form of cell death that can be regulated by various biomacromolecules. Each cell death modalities have their distinct morphological changes and molecular mechanisms.
Yongxin Zheng +4 more
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ACSL4 at the helm of the lipid peroxidation ship: a deep-sea exploration towards ferroptosis [PDF]
Frontiers in PharmacologyLipid peroxidation stands as a prominent hallmark and a prerequisite for the onset of ferroptosis. Lipid metabolism holds a pivotal role in regulating this process, forming the metabolic foundation for cellular sensitivity to ferroptosis.
Yulang Jiang +8 more
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Correlation of Lipid Peroxidation with Glycated Haemoglobin Levels in Diabetes Mellitus [PDF]
Online Journal of Health & Allied Sciences, 2011 Reactive oxygen species are crucial to normal biological processes; they are potentially dangerous and are commonly referred to as prooxidants. The reactive oxygen intermediates can cause direct cellular injury by including lipid and protein peroxidation
Varashree BS, Gopalakrishna Bhat P
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Endogenous Derivatives of Linoleic Acid and their Stable Analogs Are Potential Pain Mediators
JID Innovations, 2023 Psoriasis is characterized by intense pruritus, with a subset of individuals with psoriasis experiencing thermal hypersensitivity. However, the pathophysiology of thermal hypersensitivity in psoriasis and other skin conditions remains enigmatic. Linoleic
Joshua J. Wheeler +7 more
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Metabolites, 2023 A previous report showed that 12-week lowering of dietary omega-6 linoleic acid (LA) coupled with increased omega-3 polyunsaturated fatty acid (PUFA) intake (H3-L6 diet) reduced headache frequency and improved quality of life in patients with chronic ...
Qing Shen +9 more
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ROS induced lipid peroxidation and their role in ferroptosis
Frontiers in Cell and Developmental Biology, 2023 Reactive oxygen species (ROS) play a crucial part in the process of cell death, including apoptosis, autophagy, and ferroptosis. ROS involves in the oxidation of lipids and generate 4-hydroxynonenal and other compounds associated with it. Ferroptosis may
H. Endale +2 more
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Frontiers in Pain Research, 2023 BackgroundMigraine is a prevalent disabling condition often associated with comorbid physical and psychological symptoms that contribute to impaired quality of life and disability.
Keturah R. Faurot +15 more
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Acta Neuropathologica Communications, 2023 In sporadic Alzheimer’s disease (sAD) specific regions, layers and neurons accumulate hyperphosphorylated Tau (pTau) and degenerate early while others remain unaffected even in advanced disease.
Christopher E. Ramsden +11 more
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