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Lipid Peroxidation and Antioxidant Protection

Biomolecules, 2023
Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological systems, owing to its interplay with ferroptosis and to its role in secondary damage to other biomolecules, such as proteins.
Luca Valgimigli
doaj   +5 more sources

Lipid Peroxidation in Neurodegeneration [PDF]

Antioxidants, 2021
Neurodegenerative diseases have multiple social and economic impacts on society, and they are the cause of millions of deaths every year [...]
Consuelo Cháfer-Pericás
doaj   +3 more sources

Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications [PDF]

Cell Death and Disease
Regulated cell death (RCD) refers to the form of cell death that can be regulated by various biomacromolecules. Each cell death modalities have their distinct morphological changes and molecular mechanisms.
Yongxin Zheng, Junlu Sun, Zhiting Luo, Yimin Li, Yongbo Huang   +4 more
doaj   +2 more sources

Natural ingredients in the regulation of abnormal lipid peroxidation: a potential therapy for pulmonary diseases [PDF]

Frontiers in Pharmacology
Pulmonary diseases are a major category of diseases that pose a threat to human health. The most common drugs currently used to treat lung diseases are still chemical drugs, but this may lead to drug resistance and damage to healthy organs in the body ...
Yundou Liu, Chunyi Wang, Mengru Li, Yi Zhu, Ke Liu, Yufei Liu, Maocai Luo, Chuantao Zhang   +7 more
doaj   +2 more sources

Lipid peroxidation in cell death

Biochemical and Biophysical Research Communications, 2017
Disruption of redox homeostasis is a key phenotype of many pathological conditions. Though multiple oxidizing compounds such as hydrogen peroxide are widely recognized as mediators and inducers of oxidative stress, increasingly, attention is focused on the role of lipid hydroperoxides as critical mediators of death and disease. As the main component of
Michael M. Gaschler, Brent R. Stockwell
openaire   +4 more sources

Associations between Plasma Lipid Mediators and Chronic Daily Headache Outcomes in Patients Randomized to a Low Linoleic Acid Diet with or without Added Omega-3 Fatty Acids

Metabolites, 2023
A previous report showed that 12-week lowering of dietary omega-6 linoleic acid (LA) coupled with increased omega-3 polyunsaturated fatty acid (PUFA) intake (H3-L6 diet) reduced headache frequency and improved quality of life in patients with chronic ...
Qing Shen, Jun Yang, Daisy Zamora, Mark Horowitz, Keturah R. Faurot, Beth A. MacIntosh, J. Douglas Mann, Bruce D. Hammock, Christopher E. Ramsden, Ameer Y. Taha   +9 more
doaj   +1 more source

Dietary fatty acids improve perceived sleep quality, stress, and health in migraine: a secondary analysis of a randomized controlled trial

Frontiers in Pain Research, 2023
BackgroundMigraine is a prevalent disabling condition often associated with comorbid physical and psychological symptoms that contribute to impaired quality of life and disability.
Keturah R. Faurot, Jinyoung Park, Vanessa Miller, Gilson Honvoh, Anthony Domeniciello, J. Douglas Mann, Susan A. Gaylord, Chanee E. Lynch, Olafur Palsson, Christopher E. Ramsden, Christopher E. Ramsden, Beth A. MacIntosh, Mark Horowitz, Daisy Zamora, Daisy Zamora, Daisy Zamora   +15 more
doaj   +1 more source

Polyunsaturated Fatty Acids Drive Lipid Peroxidation during Ferroptosis

Cells, 2023
Ferroptosis is a form of regulated cell death that is intricately linked to cellular metabolism. In the forefront of research on ferroptosis, the peroxidation of polyunsaturated fatty acids has emerged as a key driver of oxidative damage to cellular ...
Michael S. Mortensen, Jimena Ruiz, J. Watts   +2 more
semanticscholar   +1 more source

ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer’s disease

Acta Neuropathologica Communications, 2023
In sporadic Alzheimer’s disease (sAD) specific regions, layers and neurons accumulate hyperphosphorylated Tau (pTau) and degenerate early while others remain unaffected even in advanced disease.
Christopher E. Ramsden, Daisy Zamora, Mark S. Horowitz, Jahandar Jahanipour, Elizabeth Calzada, Xiufeng Li, Gregory S. Keyes, Helen C. Murray, Maurice A. Curtis, Richard M. Faull, Andrea Sedlock, Dragan Maric   +11 more
doaj   +1 more source

ROS induced lipid peroxidation and their role in ferroptosis

Frontiers in Cell and Developmental Biology, 2023
Reactive oxygen species (ROS) play a crucial part in the process of cell death, including apoptosis, autophagy, and ferroptosis. ROS involves in the oxidation of lipids and generate 4-hydroxynonenal and other compounds associated with it. Ferroptosis may
H. Endale, Winta Tesfaye, Tiget Ayelgn Mengstie   +2 more
semanticscholar   +1 more source