Results 151 to 160 of about 306,329 (170)
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Lipid Peroxidation in Diabetes Mellitus
Antioxidants & Redox Signaling, 2005There is considerable evidence that hyperglycemia represents the main cause of complications of diabetes mellitus (DM), and oxidative stress resulting from increased generation of reactive oxygen species plays a crucial role in their pathogenesis. In fact, in the absence of an appropriate response from endogenous antioxidant mechanisms, the redox ...
DAVI', Giovanni, FALCO A, PATRONO C.
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Rabbit liver microsomal lipid peroxidation The effect of lipid on the rate of peroxidation
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1982Rat and rabbit liver microsomes catalyze an NADPH-cytochrome P-450 reductase-dependent peroxidation of endogenous lipid in the presence of the chelate, ADP-Fe3+. Although liver microsomes from both species contain comparable levels of NADPH-cytochrome P-450 reductase and cytochrome P-450, the rate of lipid peroxidation (assayed by malondialdehyde and ...
Ming Tien, Steven D. Aust
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Hydrogen peroxide and hematin in microsomal lipid peroxidation
Journal of Inorganic Biochemistry, 1981Lipids of rat liver microsomes underwent peroxidation with production of malondialdehyde in the presence of H2O2 and hematin. Rates of peroxidation of 27-33 nmol of MDA formed/mg of microsomal protein/30 min were measured with 5 mM H2O2 and 10 microM hematin at 22 degrees C. Histidine (0.01 M) caused a 55% inhibition.
URSINI, FULVIO +4 more
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Lipid peroxidation in tumour cells
Free Radical Biology and Medicine, 1988Several studies point to the existence of a disturbance in the metabolism of the reactive species of oxygen in cancer cells. Based on this evidence, and in particular on a characteristic behaviour of tumour membrane lipids, namely their growth-related resistance to oxy-radical-induced peroxidation, a sequence of events is outlined that could ...
L. Masotti +2 more
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[30] Microsomal lipid peroxidation
1978Publisher Summary This chapter discusses microsomal lipid peroxidation. Lipid peroxidation is a complex process known to occur in both plants and animals. It involves the formation and propagation of lipid radicals, the uptake of oxygen, a rearrangement of the double bonds in unsaturated lipids, and the eventual destruction of membrane lipids ...
Steven D. Aust, John A. Buege
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Transferrin-dependent lipid peroxidation
Advances in Free Radical Biology & Medicine, 1986The potential for iron bound to transferrin to be released and promote the peroxidation of phospholipid liposomes was investigated using ADP as a low molecular weight chelator and superoxide generated by the xanthine/xanthine oxidase system as the reducing agent.
Morio Saito +2 more
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Assays for the Measurement of Lipid Peroxidation
2012Physical and emotional stress, metabolic alterations, carcinogenesis or inflammation are conditions that can trigger oxidative stress, which is defined as a balance shift of redox reactions towards oxidation, resulting in the increase of reactive oxygen species (ROS). ROS are continuously formed in small quantities during the normal metabolism of cell,
Branka Mihaljević +4 more
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Lipid peroxidation in the pathogenesis of neuroborreliosis
Free Radical Biology and Medicine, 2016This study analyzed the onset of lipid peroxidation (LPO) in neuroborreliosis and the effects of ceftriaxone therapy on LPO. Twenty-two patients with early neuroborreliosis and 22 healthy subjects were studied. LPO in the cerebrospinal fluid (CSF), as well as the plasma and urine was estimated by the levels of reactive aldehydes: 4-hydroxynonenal (4 ...
Wojciech Łuczaj +7 more
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Resveratrol inhibition of lipid peroxidation
Free Radical Research, 2000To define the molecular mechanism(s) of resveratrol inhibition of lipid peroxidation we have utilized model systems that allow us to study the different reactions involved in this complex process. Resveratrol proved (a) to inhibit more efficiently than either Trolox or ascorbate the Fe2+ catalyzed lipid hydroperoxide-dependent peroxidation of sonicated
TADOLINI B +4 more
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[32] Chemistry of lipid peroxidation
1984The free radical chemistry of lipid peroxidation is complex. The classical mechanism of autoxidation involving a peroxy radical abstracting hydrogen atom from lipid and oxygen addition to the carbon radical thus formed must be modified to include (1) peroxy radical beta fragmentation and (2) peroxy radical cyclization.
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