Results 11 to 20 of about 208,197 (313)

Mitochondrial Lipid Peroxidation Is Responsible for Ferroptosis

open access: yesCells, 2023
Ferroptosis induced by erastin (an inhibitor of cystine transport) and butionine sulfoximine (an inhibitor of glutathione biosynthesis) was prevented by the mitochondria-targeted antioxidants SkQ1 and MitoTEMPO.
Konstantin G. Lyamzaev   +4 more
doaj   +1 more source

Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration

open access: yesNeural Regeneration Research, 2023
Lipid peroxidation and iron accumulation are closely associated with neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, or neurodegeneration with brain iron accumulation disorders.
Irene Villalón-García   +10 more
doaj   +1 more source

Lipid Peroxidation

open access: yes, 2021
Lipid peroxidation (LPO) is initiated by the attack of free radicals (eg OH ·, O2- and H2O2) on cellular or organelle membranes phospholipids or polyunsaturated fatty acids (PUFA), and with the formation of various types of aldehydes, ketones, alkanes, carboxylic acids and polymerization products. It is an autoxidation process that results.
Onur, Yaman, Suzan, Adnan, Ayhanci,
openaire   +3 more sources

Generation of singlet oxygen via iron-dependent lipid peroxidation and its role in Ferroptosis

open access: yesFundamental Research, 2022
Ferroptosis is a cell death pathway mediated by iron-dependent accumulation of lipid peroxide. However, the specific downstream molecular events of iron-dependent lipid peroxidation are yet to be elucidated.
Xiaofei Zhang   +4 more
doaj   +1 more source

Evaluating the In Vitro Potential of Natural Extracts to Protect Lipids from Oxidative Damage

open access: yesAntioxidants, 2020
Lipid peroxidation is a chemical reaction known to have negative impacts on living organisms’ health and on consumer products’ quality and safety.
Rafael Félix   +5 more
doaj   +1 more source

Reactive Oxygen Species, Lipid Peroxidation and Antioxidative Defense Mechanism

open access: yesNotulae Botanicae Horti Agrobotanici Cluj-Napoca, 2013
Lipid peroxidation can be defined as the oxidative deterioration of lipids containing any number of carbon-carbon double bonds. Lipid peroxidation is a well-established mechanism of cellular injury in both plants and animals, and is used as an indicator ...
Hossam S. EL-BELTAGI, Heba I. MOHAMED
doaj   +1 more source

Sphingomyelins Prevent Propagation of Lipid Peroxidation—LC-MS/MS Evaluation of Inhibition Mechanisms

open access: yesMolecules, 2020
Free radical driven lipid peroxidation is a chain reaction which can lead to oxidative degradation of biological membranes. Propagation vs. termination rates of peroxidation in biological membranes are determined by a variety of factors including fatty ...
Giulia Coliva   +5 more
doaj   +1 more source

IL-9/STAT3/fatty acid oxidation–mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity

open access: yesThe Journal of Clinical Investigation, 2022
CD8+ T cell longevity regulated by metabolic activity plays important roles in cancer immunotherapy. Although in vitro–polarized, transferred IL-9–secreting CD8+ Tc9 (cytotoxic T lymphocyte subset 9) cells exert greater persistence and antitumor efficacy
Liuling Xiao   +10 more
doaj   +1 more source

Lipid Peroxidation and Antioxidant Protection

open access: yesBiomolecules, 2023
Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological systems, owing to its interplay with ferroptosis and to its role in secondary damage to other biomolecules, such as proteins.
Luca Valgimigli
doaj   +1 more source

Lipid Peroxidation in Oral Cancer [PDF]

open access: yesBasrah Journal of Surgery, 2003
In this study, 20 patients with oral cancer (confirmed by histopathological examination) and 21 control subjects were included, to evaluate the degree of lipid peroxidation (LP) in oral cancer.
Ghaydaa H. Badri
doaj   +1 more source

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