Results 181 to 190 of about 87,561 (363)

Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system.

, 1975
E. W. Kellogg, Irwin Fridovich
openalex   +1 more source

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases [PDF]

, 2019
Heart failure (HF) is a highly complex disorder and a major end-point of cardiovascular diseases (CVD). The pathogenesis of HF is mostly unresolved but involves interplay between cardiac structural and electrical remodelling, metabolic alterations, cell ...
Kasi Ganeshan, T., Kasi Ganeshan, T.
core  

Nanoplasmonic Infrared Microarray Sensor Enabling Structural Protein Biomarker‐Based Drug Screening for Neurodegenerative Diseases

Advanced Science, EarlyView.
This work introduces an on‐chip, integrated plasmonic infrared microarray sensor that enables high‐throughput, label‐free drug screening targeting structural protein biomarkers in neurodegenerative diseases. Through ultra‐compact microwell arrays, the sensor achieves ultra‐sensitive, rapid, and multiplexed secondary structural analysis of the effect of
Deepthy Kavungal, Enzo Morro, Senthil T Kumar, Berkay Dagli, Hilal A Lashuel, Hatice Altug   +5 more
wiley   +1 more source

Ultrathin Multi‐Doped Molybdenum Oxide Nanodots as a Tunable Selective Biocatalyst

Advanced Science, EarlyView.
This paper presents an advanced multi‐doped molybdenum oxide nanodots with tunable ammonium and proton doping, exhibiting strong ROS generation. The material demonstrates ultrafast and complete dye degradation and unique selective toxicity toward cancer cells, highlighting its promising potential for cancer therapy applications.
Bao Yue Zhang, Farjana Haque, Shwathy Ramesan, Sanjida Afrin, Muhammad Waqas Khan, Haibo Ding, Xin Zhou, Qijie Ma, Jiaru Zhang, Rui Ou, Md Mohiuddin, Enamul Haque, Yichao Wang, Azmira Jannat, Yumin Li, Robi S. Datta, Kate Fox, Guolang Li, Hujun Jia, Jian Zhen Ou   +19 more
wiley   +1 more source

The effect of consuming oxidized oil supplemented with fiber on lipid profiles in rat model

Journal of Research in Medical Sciences, 2011
Background: This study was conducted to evaluate the effects of consuming thermally oxidized oil supplemented with pectin on liver glutathione peroxidase activity, serum malondialdehyde and lipid profiles in male Sprague-Dawley rats.
Shila Shafaeizadeh, Jalal Jamalian, Ali Akbare Owji, Leila Azadbakht, Roghayeh Ramezani, Narges Karbalaei, Abdolreza Rajaeifard, Negar Tabatabai   +7 more
doaj  

Melatonin Modulates Glucose Metabolism Reprogramming via Targeting G6PD to Alleviate Lead‐Induced Hepatocytes Pyroptosis in Common Carp (Cyprinus carpio L.)

Advanced Science, EarlyView.
This study reveals that Lead reprograms glucose metabolism to enhance H3K18la, driving DRP1‐dependent mitochondrial DNA leakage and cGAS‐STING‐mediated pyroptosis. Melatonin targets G6PD to suppress glycolysis‐driven H3K18la and restore mitochondrial homeostasis, thereby alleviating Lead‐induced liver injury in common carp through disruption of the ...
Zhiying Miao, Xiaofeng Ji, Lai Wei, Zhiruo Miao, Shiwen Xu   +4 more
wiley   +1 more source

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

EFFECT OF LIPID PEROXIDATION ON PHOSPHOLIPASE A2 ACTIVITY OF RAT LIVER MITOCHONDRIA

, 1977
Masahide Yasuda, Tadashi Fujita
openalex   +1 more source

Single‐Cell Transcriptomics Unravels Growth Factor Erv1‐Like Mediated Ferroptosis as a Key Driver of Intestinal Epithelial Dysfunction in Ulcerative Colitis

Advanced Science, EarlyView.
Single‐cell transcriptomic profiling of ulcerative colitis (UC) tissues identified downregulation of GFER in intestinal epithelial cells. Mechanistically, GFER interacts with PCBP1 to help maintain intracellular iron homeostasis and may also reduce lipid peroxidation by activating the PGC‐1α/PPARγ signaling pathway, thereby inhibiting ferroptosis ...
Ya Song, Fangyan Tan, Qian Song, Xiaohui Liao, Zhechuan Mei, Lin Lv   +5 more
wiley   +1 more source