Transmembrane Domain Length of Influenza a Virus M2 Does Not Determine Its Non-Lipid Raft Localization [PDF]
VirusesInfluenza A virus expresses three envelope proteins, hemagglutinin (HA), neuraminidase (NA), and matrix protein 2 (M2). Of these, HA and NA associate with lipid rafts, whereas M2 remains in the peri-raft region.
Rashid Manzoor +4 more
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Primary cilia and lipid raft dynamics [PDF]
Open Biology, 2021 Primary cilia, antenna-like structures of the plasma membrane, detect various extracellular cues and transduce signals into the cell to regulate a wide range of functions.
Yuhei Nishimura +5 more
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Lipid Raft Membrane Interactivity Correlating with Cyclooxygenase-2 Selectivity of Non-Steroidal Anti-Inflammatory Drugs [PDF]
MembranesThe primary mechanism of non-steroidal anti-inflammatory drugs (NSAIDs) is inhibition of prostaglandin production mediated by cyclooxygenase. Given the possible association of cyclooxygenase-2, but not cyclooxygenase-1, with membrane lipid rafts, we ...
Maki Mizogami +2 more
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Toluidine Blue for the Determination of Binding of Anionic Polysaccharides to Lipid Raft Domains by Absorption Spectroscopy [PDF]
MembranesThe complexes of negatively charged polysaccharides with lipid vesicles have been shown to have applications in medicine, bioremediation, water purification, and construction of nano-biosensors.
Sandra Gębczyńska +6 more
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Transcriptomic landscape based on annotated clinical features reveals PLPP2 involvement in lipid raft-mediated proliferation signature of early-stage lung adenocarcinoma [PDF]
Journal of Experimental & Clinical Cancer Research, 2023 Background Image-based screening improves the detection of early-stage lung adenocarcinoma (LUAD)but also highlights the issue of high false-positive diagnoses, which puts patients at a risk of unnecessary over-treatment.
Yibei Wang +10 more
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ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export [PDF]
Nature CommunicationsThe determinants of sub-cellular trafficking for many membrane proteins are poorly understood. Lipid-driven membrane nanodomains known as lipid rafts have been widely implicated in post-Golgi traffic, but their involvement in protein sorting in the ...
Ivan Castello-Serrano +4 more
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Frontiers in Cell and Developmental Biology, 2021 BackgroundNicotine exerts direct effects on multiple cell types in the cardiovascular system by associating with its high-affinity nicotinic acetylcholine receptors (nAchRs).
Fengqi Duan +8 more
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Cold induces micro- and nano-scale reorganization of lipid raft markers at mounds of T-cell membrane fluctuations. [PDF]
PLoS ONE, 2009 Whether and how cold causes changes in cell-membrane or lipid rafts remain poorly characterized. Using the NSOM/QD and confocal imaging systems, we found that cold caused microscale redistribution of lipid raft markers, GM1 for lipid and CD59 for protein,
Yong Chen +3 more
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Interaction of drugs with lipid raft membrane domains as a possible target
Drug Target Insights, 2020 Introduction: Plasma membranes are not the homogeneous bilayers of uniformly distributed lipids but the lipid complex with laterally separated lipid raft membrane domains, which provide receptor, ion channel and enzyme proteins with a platform.
Hironori Tsuchiya, Maki Mizogami
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Role of membrane microdomains in compartmentation of cAMP signaling. [PDF]
PLoS ONE, 2014 Spatially restricting cAMP production to discrete subcellular locations permits selective regulation of specific functional responses. But exactly where and how cAMP signaling is confined is not fully understood.
Shailesh R Agarwal +7 more
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