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Structure of Cholesterol in Lipid Rafts [PDF]
Physical Review Letters, 2014 Rafts, or functional domains, are transient nano- or mesoscopic structures in the plasma membrane and are thought to be essential for many cellular processes such as signal transduction, adhesion, trafficking and lipid/protein sorting. Observations of these membrane heterogeneities have proven challenging, as they are thought to be both small and short-
Zahra Yamani +6 more
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Frontiers in Cell and Developmental Biology, 2021 Chemosensitization of cancer cells with small molecules may improve the therapeutic index of antitumoral agents by making tumor cells sensitive to the drug regimen and thus overcome the treatment resistance and side effects of single therapy.
Siddhartha Kumar Mishra +7 more
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Lenalidomide induces lipid raft assembly to enhance erythropoietin receptor signaling in myelodysplastic syndrome progenitors. [PDF]
PLoS ONE, 2014 Anemia remains the principal management challenge for patients with lower risk Myelodysplastic Syndromes (MDS). Despite appropriate cytokine production and cellular receptor display, erythropoietin receptor (EpoR) signaling is impaired.
Kathy L McGraw +10 more
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Cell, 2003 There has been considerable recent interest in the possibility that the plasma membrane contains lipid "rafts," microdomains enriched in cholesterol and sphingolipids. It has been suggested that such rafts could play an important role in many cellular processes including signal transduction, membrane trafficking, cytoskeletal organization, and pathogen
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, 1968 Acute cholesterol depletion is generally associated with decreased or abolished T cell signalling but it can also cause T cell activation. This anomaly has been addressed in Jurkat T cells using progressive cholesterol depletion with methyl-beta ...
Adler, Jeremy +3 more
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Planta, 2005 About two decades ago a provocative hypothesis evolved suggesting that the plasma membrane (PM) of mammalian and probably other eukaryotic cells constitutes a mosaic of patches comprising particular molecular compositions. These scattered lipid bilayer microdomains are supposedly enriched in sterols as well as sphingolipids and depleted in unsaturated ...
Bhat, R., Panstruga, R.
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Lipid rafts and membrane dynamics [PDF]
Journal of Cell Science, 2005 Cell membranes contain a variety of lipid species that differ in their physico-chemical properties. Lipid-lipid immiscibility gives rise to lateral heterogeneities in the membrane plane, a subset of which are termed lipid rafts ([Simons and Vaz, 2004][1]).
Rajendran, L, Simons, K
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A coupled surface-Cahn--Hilliard bulk-diffusion system modeling lipid raft formation in cell membranes [PDF]
, 2015 We propose and investigate a model for lipid raft formation and dynamics in biological membranes. The model describes the lipid composition of the membrane and an interaction with cholesterol.
H. Garcke +3 more
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Alterations of membrane curvature during influenza virus budding [PDF]
, 2014 Influenza A virus belongs to the Orthomyxoviridae family. It is an enveloped virus that contains a segmented and negative-sense RNA genome. Influenza A viruses cause annual epidemics and occasional major pandemics, are a major cause of morbidity and ...
Agnieszka Martyna +29 more
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Lipid rafts and membrane traffic [PDF]
FEBS Letters, 2007 Membrane rafts are regions of increased lipid acyl chain order that differ in their lipid and protein composition from the surrounding membrane. By providing an additional level of compartmentalization they have been proposed to serve many functions in cellular signal transduction and trafficking. We will review their potential involvement in different
Hanzal-Bayer, M. F., Hancock, J. F.
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