Results 31 to 40 of about 69,365 (334)

Lenalidomide induces lipid raft assembly to enhance erythropoietin receptor signaling in myelodysplastic syndrome progenitors. [PDF]

PLoS ONE, 2014
Anemia remains the principal management challenge for patients with lower risk Myelodysplastic Syndromes (MDS). Despite appropriate cytokine production and cellular receptor display, erythropoietin receptor (EpoR) signaling is impaired.
Kathy L McGraw, Ashley A Basiorka, Joseph O Johnson, Justine Clark, Gisela Caceres, Eric Padron, Ruth Heaton, Yukiyasu Ozawa, Sheng Wei, Lubomir Sokol, Alan F List   +10 more
doaj   +1 more source

Mild Heat Treatment Primes Human CD34(+) Cord Blood Cells for Migration Toward SDF-1α and Enhances Engraftment in an NSG Mouse Model [PDF]

, 2015
Simple efforts are needed to enhance cord blood (CB) transplantation. We hypothesized that short-term exposure of CD34(+) CB cells to 39.5°C would enhance their response to stromal-derived factor-1 (SDF-1), by increasing lipid raft aggregation and CXCR4 ...
Broxmeyer, Hal E., Capitano, Maegan L., Cooper, Scott, Hangoc, Giao   +3 more
core   +1 more source

Synthesis and structural characterization of a mimetic membrane-anchored prion protein [PDF]

, 2006
During pathogenesis of transmissible spongiform encephalopathies (TSEs) an abnormal form (PrPSc) of the host encoded prion protein (PrPC) accumulates in insoluble fibrils and plaques. The two forms of PrP appear to have identical covalent structures, but
Andrew C. Gill, Ansari AA, Atvinder K. Rullay, Bertozzi CR, Blanch EW, Borchelt D, Caughey B, Caughey B, Caughey B, Caughey BW, Critchley P, David H. Crout, Eberl H, Ferris A, Georges C, Gill AC, Govaerts C, Haire LF, Harris DA, Hornemann S, Ian D. Sylvester, Imanpreet K. Bath, Kazlauskaite J, Kazlauskaite J, Kenyon GL, King SA, Kirby L, Klein TR, Kocienski PJ, Legname G, Matthew R. Hicks, Mui B, Nosjean O, Pan KM, Poss AJ, Safar J, Seddon AM, Shyng SL, Stahl N, Stahl N, Teresa J. T. Pinheiro, Whitesell JK, Wuthrich K, Zahn R, Zhang ZY   +44 more
core   +1 more source

The Lipid Raft Proteome of African Trypanosomes Contains Many Flagellar Proteins

Pathogens, 2017
Lipid rafts are liquid-ordered membrane microdomains that form by preferential association of 3-β-hydroxysterols, sphingolipids and raft-associated proteins often having acyl modifications.
Aabha I. Sharma, Cheryl L. Olson, David M. Engman   +2 more
doaj   +1 more source

Impairment of Membrane Lipid Homeostasis by Bichalcone Analog TSWU-BR4 Attenuates Function of GRP78 in Regulation of the Oxidative Balance and Invasion of Cancer Cells

Cells, 2020
The specialized cholesterol/sphingolipid-rich membrane domains termed lipid rafts are highly dynamic in the cancer cells, which rapidly assemble effector molecules to form a sorting platform essential for oncogenic signaling transduction in response to ...
Tsung-Lin Lee, Shyang-Guang Wang, Wen-Ling Chan, Ching-Hsiao Lee, Tian-Shung Wu, Meng-Liang Lin, Shih-Shun Chen   +6 more
doaj   +1 more source

Hematopoiesis is regulated by cholesterol efflux pathways and lipid rafts: connections with cardiovascular diseases

Journal of Lipid Research, 2020
Lipid rafts are highly ordered regions of the plasma membrane that are enriched in cholesterol and sphingolipids and play important roles in many cells.
Pooranee K. Morgan, Longhou Fang, Graeme I. Lancaster, Andrew J. Murphy   +3 more
doaj   +1 more source

Evidence for the involvement of lipid rafts localized at the ER-mitochondria associated membranes in autophagosome formation [PDF]

, 2016
Mitochondria-associated membranes (MAMs) are subdomains of the endoplasmic reticulum (ER) that interact with mitochondria. This membrane scrambling between ER and mitochondria appears to play a critical role in the earliest steps of autophagy.
Faggioni, Alberto, Gambardella, Lucrezia, Garofalo, Tina, Malorni, Walter, Manganelli, Valeria, Marconi, Matteo, Matarrese, Paola, Misasi, Roberta, Sorice, Maurizio, Tinari, Antonella   +9 more
core   +2 more sources

Compartmentalized cAMP Signaling Associated With Lipid Raft and Non-raft Membrane Domains in Adult Ventricular Myocytes

Frontiers in Pharmacology, 2018
Aim: Confining cAMP production to discrete subcellular locations makes it possible for this ubiquitous second messenger to elicit unique functional responses.
Shailesh R. Agarwal, Jackson Gratwohl, Mia Cozad, Pei-Chi Yang, Colleen E. Clancy, Robert D. Harvey   +5 more
doaj   +1 more source

Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells. [PDF]

, 2019
HIV infection has a profound effect on "bystander" cells causing metabolic co-morbidities. This may be mediated by exosomes secreted by HIV-infected cells and containing viral factors.
Brichacek, Beda, Bukrinsky, Michael, Ditiatkovski, Michael, Dragoljevic, Dragana, Dubrovsky, Larisa, Fu, Ying, Hoang, Anh, Horvath, Anelia, Low, Hann, Meikle, Peter J, Miller, Yury I, Mukhamedova, Nigora, Murphy, Andrew, Ohkawa, Ryunosuke, Pushkarsky, Tatiana, Sviridov, Dmitri   +15 more
core   +3 more sources

Lipid Rafts and Pseudotyping [PDF]

Journal of Virology, 2001
ABSTRACTSpecific interactions between envelope and core proteins govern the membrane assembly of most enveloped viruses. Despite this, mixed infections lead to pseudotyping, the association of the viral cores of one virus with the envelopes of another. How does this occur?
W F, Pickl, F X, Pimentel-Muiños, B, Seed   +2 more
openaire   +2 more sources