Results 51 to 60 of about 69,365 (334)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The trafficking and targeting of P2X receptors [PDF]
, 2013 The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very ...
Murrell-Lagnado, Ruth D +1 more
core +3 more sources
MicroorganismsSevere acute respiratory syndrome coronavirus (SARS-CoV) assembles and buds from the Golgi apparatus or the ER membrane, but the specific membrane microdomains utilized during this process remain underexplored.
Manoj K. Pastey +2 more
doaj +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Bordetella parapertussis Survives inside Human Macrophages in Lipid Raft-Enriched Phagosomes [PDF]
, 2014 Bordetella parapertussis is a human pathogen that causes whooping cough. The increasing incidence of B. parapertussis has been attributed to the lack of cross protection induced by pertussis vaccines. It was previously shown that B. parapertussis is able
Gorgojo, Juan Pablo +2 more
core +3 more sources
Plant Physiology, 2007 Current thinking on lipid membrane organization has evolved from the seminal fluid mosaic model proposed by [Singer and Nicolson (1972)][1]. Subsequent studies on plasma membranes suggest that biological membranes are not a simple homogeneous layer of proteins and lipids, but rather are ...
openaire +2 more sources
Lipid Raft is required for PSGL-1 ligation induced HL-60 cell adhesion on ICAM-1. [PDF]
PLoS ONE, 2013 P-selectin glycoprotein ligand-1 (PSGL-1) and integrins are adhesion molecules that play critical roles in host defense and innate immunity. PSGL-1 mediates leukocyte rolling and primes leukocytes for integrin-mediated adhesion.
Tingshuang Xu +8 more
doaj +1 more source
Advanced Functional Materials, EarlyView.Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz +3 more
wiley +1 more source
Lipid rafts and membrane dynamics [PDF]
Journal of Cell Science, 2005 Cell membranes contain a variety of lipid species that differ in their physico-chemical properties. Lipid-lipid immiscibility gives rise to lateral heterogeneities in the membrane plane, a subset of which are termed lipid rafts ([Simons and Vaz, 2004][1]).
Rajendran, L, Simons, K
openaire +3 more sources
Lipid Rafts and Plant Gravisensitivity
Life, 2022 The necessity to include plants as a component of a Bioregenerative Life Support System leads to investigations to optimize plant growth facilities as well as a better understanding of the plant cell membrane and its numerous activities in the signaling, transport, and sensing of gravity, drought, and other stressors.
Elizabeth L. Kordyum +2 more
openaire +3 more sources