Results 61 to 70 of about 1,129,041 (391)

A novel mechanism of regulating breast cancer cell migration via palmitoylation-dependent alterations in the lipid raft affiliation of CD44

Breast Cancer Research, 2014
IntroductionMost breast cancer-related deaths result from metastasis, a process involving dynamic regulation of tumour cell adhesion and migration. The adhesion protein CD44, a key regulator of cell migration, is enriched in cholesterol-enriched membrane
I. Babina, E. McSherry, S. Donatello, A. Hill, A. Hopkins   +4 more
semanticscholar   +1 more source

Proteomic identification of ADAM12 as a regulator for TGF-β1-induced differentiation of human mesenchymal stem cells to smooth muscle cells. [PDF]

PLoS ONE, 2012
Transforming growth factor-β1 (TGF-β1) induces the differentiation of human adipose tissue-derived mesenchymal stem cells (hASCs) into smooth muscle cells. Lipid rafts are cholesterol-rich microdomains in cell membranes that reportedly play a key role in
Young Mi Kim, Jaeyoon Kim, Soon Chul Heo, Sang Hun Shin, Eun Kyoung Do, Dong-Soo Suh, Ki-Hyung Kim, Man-Soo Yoon, Taehoon G Lee, Jae Ho Kim   +9 more
doaj   +1 more source

The challenge of lipid rafts

Journal of Lipid Research, 2009
The Singer-Nicholson model of membranes postulated a uniform lipid bilayer randomly studded with floating proteins. However, it became clear almost immediately that membranes were not uniform and that clusters of lipids in a more ordered state existed within the generally disorder lipid milieu of the membrane.
openaire   +4 more sources

Lipid rafts as a therapeutic target

Journal of Lipid Research, 2020
Lipid rafts regulate the initiation of cellular metabolic and signaling pathways by organizing the pathway components in ordered microdomains on the cell surface. Cellular responses regulated by lipid rafts range from physiological to pathological, and the success of a therapeutic approach targeting "pathological" lipid rafts depends on the ability of ...
Dmitri Sviridov, Nigora Mukhamedova, Yury I. Miller   +2 more
openaire   +3 more sources

Selective Cholesterol Dynamics between Lipoproteins and Caveolae/Lipid Rafts [PDF]

, 2007
Although low-density lipoprotein (LDL) receptor-mediated cholesterol uptake through clathrin-coated pits is now well understood, the molecular details and organizing principles for selective cholesterol uptake/efflux (reverse cholesterol transport, RCT ...
Atshaves, Barbara P., Ball, Judith M., Gallegos, Adalberto M., Kier, Ann B., Landrock, Kerstin K., Martin, Gregory G., McIntosh, Avery L., Parr, Rebecca D., Schroeder, Friedhelm, Storey, Stephen M.   +9 more
core   +2 more sources

RaftProt: mammalian lipid raft proteome database

Nucleic Acids Res., 2014
RaftProt (http://lipid-raft-database.di.uq.edu.au/) is a database of mammalian lipid raft-associated proteins as reported in high-throughput mass spectrometry studies.
Anup D. Shah, David Chen, Akash R. Boda, L. Foster, Melissa J. Davis, M. Hill   +5 more
semanticscholar   +1 more source

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

Journal of Biological Chemistry, 2013
Background: Exosome vesicles can transfer molecular information previously shown to stimulate tumor development; however, the mechanism of exosome uptake is unknown.
Katrin J. Svensson, H. Christianson, Anders Wittrup, E. Bourseau-Guilmain, E. Lindqvist, L. Svensson, M. Mörgelin, M. Belting   +7 more
semanticscholar   +1 more source

Lipid-rafts remain stable even after ionizing radiation induced disintegration of β1 integrin containing focal adhesions

BMC Research Notes, 2017
Objective Adhesion of cells to the extracellular matrix is facilitated by integrin receptors. We recently found that a nanoscale organization of plasma membrane located integrins containing the β1 subunit is responsible for an enhanced radio-resistance ...
Laura Babel, Larissa Kruse, Steven Bump, Markus Langhans, Tobias Meckel   +4 more
doaj   +1 more source

The trafficking and targeting of P2X receptors [PDF]

, 2013
The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very ...
Murrell-Lagnado, Ruth D, Robinson, Lucy E   +1 more
core   +3 more sources

Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances

Cell Death and Disease, 2014
Intracellular accumulations of altered, misfolded proteins in neuronal and other cells are pathological hallmarks shared by many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS).
J. T. Vollrath, Antonio Sechi, A. Dreser, Istvan Katona, Dominik Wiemuth, Jörg Vervoorts, Marc Dohmen, Akila Chandrasekar, J. Prause, E. Brauers, C. M. Jesse, Joachim Weis, A. Goswami   +12 more
semanticscholar   +1 more source