Results 221 to 230 of about 75,080 (297)

Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells. [PDF]

Sci Adv
Gad AZ, Morris JS, Godret-Miertschin L, Montalvo MJ, Kerr SS, Berger H, Lee JCH, Saadeldin AM, Abu-Arja MH, Xu S, Vasileiou S, Brock RM, Fousek K, Sheha MF, Srinivasan M, Li Y, Saeedi A, R Levental K, Leen AM, Mamonkin M, Carisey A, Varadarajan N, Hegde M, Joseph SK, Levental I, Levental I, Mukherjee M, Ahmed N.   +27 more
europepmc   +1 more source

PIEZO1 Channels Modulate the Small Extracellular Vesicle Release in C2C12 Cells

Journal of Cellular Physiology, Volume 241, Issue 3, March 2026.
ABSTRACT PIEZO1 are mechanically‐activated ion channels expressed in many cell types. Their pharmacological activation by the selective agonist Yoda1 has been reported to favor skeletal muscle regeneration by controlling the fate of myogenic precursors cells, but the underlying mechanisms remain largely unknown.
Bernareggi Annalisa, Zhang Wen Ru, Sanchez‐Sanchez Laura, Norbedo Alessia, Fracassi Anna, Lucafò Marianna, Sciancalepore Marina, Alberto Griffoni, Russell K. William, Taglialatela Giulio, Lorenzon Paola, Limon Agenor   +11 more
wiley   +1 more source

Cancer-associated VEGFR2^R1032Q sustains receptor activation also by promoting ligand-independent hetero-dimerization with co-expressed wild-type VEGFR2 and translocation into lipid rafts. [PDF]

Neoplasia
Ravelli C, Corsini M, Bresciani R, Rizzo AM, Zammataro L, Corsetto PA, Grillo E, Mitola S.   +7 more
europepmc   +1 more source

The Fatty Acid Transporter CD36 Mediates Uptake, Biodistribution, and Cardioprotection by Small Extracellular Vesicles From HEK293 Cells

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale carriers of bioactive molecules that mediate intercellular communication. Small EVs (sEVs) have shown cardioprotective effects in models of myocardial infarction (MI), but their uptake and biodistribution remain incompletely understood.
Elias Sulaiman, Derek M. Yellon, Sean M. Davidson   +2 more
wiley   +1 more source

Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts. [PDF]

Elife
Chiu PL, Orjuela JD, de Groot BL, Aponte Santamaría C, Walz T.   +4 more
europepmc   +1 more source

Small Extracellular Vesicles in Gestational Diabetes Mellitus: Current Landscape and Emerging Diagnostic Horizons

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
ABSTRACT Gestational diabetes mellitus (GDM) is a common metabolic disorder of pregnancy associated with significant maternal and neonatal morbidity and mortality. Current diagnostic strategies, particularly the oral glucose tolerance test (OGTT), are limited by late detection, variability in diagnostic criteria, and patient burden, highlighting the ...
Mai Ahmed, Dada Oluwaseyi Temilola, Mushi Matjila, Manogari Chetty   +3 more
wiley   +1 more source

SLO co-opts host cell glycosphingolipids to access cholesterol-rich lipid rafts for enhanced pore formation and cytotoxicity. [PDF]

mBio
Sanduja P, Schmieder SS, Baddal B, Tian S, Velarde JJ, Lencer WI, Dong M, Wessels MR.   +7 more
europepmc   +1 more source

Unveiling Immune System Perturbations in Early Development Through Zebrafish Models of NADHX Repair Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT The vital cofactors NADH and NADPH are prone to hydration, forming hydroxylated redox‐inactive derivatives (NADHX and NADPHX) in cells. These damaged metabolites are repaired by two highly conserved enzymes, an NAD(P)HX dehydratase (NAXD) and an NAD(P)HX epimerase (NAXE).
Myrto Patraskaki, Najmesadat Seyedkatouli, Lisa Schlicker, Marc O. Warmoes, Maria Lorena Cordero‐Maldonado, Ursula Heins‐Marroquin, Carole L. Linster   +6 more
wiley   +1 more source

Changes in Plasma Sphingolipid Metabolites Following Roux‐En‐Y Gastric Bypass in Women With Obesity and Type 2 Diabetes: A Pilot Metabolomic Cohort Study

Lipids, Volume 61, Issue 2, Page 195-205, March 2026.
ABSTRACT Although sphingolipids are key players in lipotoxicity and metabolic diseases, their response to bariatric surgery and their relation to metabolic improvement remain unclear. This pilot study investigated plasma sphingolipid remodeling after Roux‐en‐Y gastric bypass (RYGB) and its associations with clinical and biochemical markers of ...
Gabriela de Oliveira Lemos, Raquel Susana Torrinhas, Natasha Mendonça Machado, Dan Linetzky Waitzberg   +3 more
wiley   +1 more source

GDF15 promotes the resistance of epithelial ovarian cancer cells to gemcitabine via DHCR24-mediated cholesterol metabolism to elevate ABCB1 and ABCC1 levels in lipid rafts. [PDF]

Am J Cancer Res
Guo L, He Y, Xin H.
europepmc   +1 more source