Results 91 to 100 of about 6,252,566 (347)

Regulation of Membrane Turnover by Phosphatidic Acid: Cellular Functions and Disease Implications

Frontiers in Cell and Developmental Biology, 2019
Phosphatidic acid (PA) is a simple glycerophospholipid with a well-established role as an intermediate in phospholipid biosynthesis. In addition to its role in lipid biosynthesis, PA has been proposed to act as a signaling molecule that modulates several
Rajan Thakur, Amruta Naik, Aniruddha Panda, Padinjat Raghu   +3 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Extracellular Spermine Triggers a Rapid Intracellular Phosphatidic Acid Response in Arabidopsis, Involving PLDδ Activation and Stimulating Ion Flux

Frontiers in Plant Science, 2019
Polyamines, such as putrescine (Put), spermidine (Spd), and spermine (Spm), are low-molecular-weight polycationic molecules found in all living organisms.
Xavier Zarza, Xavier Zarza, Lana Shabala, Miki Fujita, Sergey Shabala, Michel A. Haring, Antonio F. Tiburcio, Teun Munnik, Teun Munnik   +8 more
doaj   +1 more source

Lipids and Lipid-Mediated Signaling in Plant–Pathogen Interactions

International Journal of Molecular Sciences
Plant lipids are essential cell constituents with many structural, storage, signaling, and defensive functions. During plant–pathogen interactions, lipids play parts in both the preexisting passive defense mechanisms and the pathogen-induced immune ...
Elżbieta Kuźniak, Ewa Gajewska
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Biochemical and molecular-genetic characterization of SFD1’s involvement in lipid metabolism and defense signaling

Frontiers in Plant Science, 2012
The Arabidopsis thaliana SFD1 (SUPPRESSOR OF FATTY ACID DESATURASE DEFICIENCY1) gene (also known as GLY1) is required for accumulation of 34:6 (i.e., 18:3-16:3) monogalactosyldiacylglycerol (MGDG) and for the activation of systemic acquired resistance ...
Katarzyna eLorenc-Kukula, Ratnesh eChaturvedi, Mary eRoth, Ruth eWelti, Jyoti eShah   +4 more
doaj   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality[S]

Journal of Lipid Research, 2013
Human mesenchymal stem/stromal cells (hMSC) are increasingly used in advanced cellular therapies. The clinical use of hMSCs demands sequential cell expansions.
Lotta Kilpinen, Feven Tigistu-Sahle, Sofia Oja, Dario Greco, Amarjit Parmar, Päivi Saavalainen, Janne Nikkilä, Matti Korhonen, Petri Lehenkari, Reijo Käkelä, Saara Laitinen   +10 more
doaj   +1 more source

SEC14 Phospholipid Transfer Protein Is Involved in Lipid Signaling-Mediated Plant Immune Responses in Nicotiana benthamiana

PLoS ONE, 2014
We previously identified a gene related to the SEC14-gene phospholipid transfer protein superfamily that is induced in Nicotiana benthamiana (NbSEC14) in response to infection with Ralstonia solanacearum. We here report that NbSEC14 plays a role in plant
A. Kiba, I. Galis, Yuko Hojo, K. Ohnishi, H. Yoshioka, Y. Hikichi   +5 more
semanticscholar   +1 more source