Results 101 to 110 of about 848,065 (307)

Biochemical and molecular-genetic characterization of SFD1’s involvement in lipid metabolism and defense signaling

Frontiers in Plant Science, 2012
The Arabidopsis thaliana SFD1 (SUPPRESSOR OF FATTY ACID DESATURASE DEFICIENCY1) gene (also known as GLY1) is required for accumulation of 34:6 (i.e., 18:3-16:3) monogalactosyldiacylglycerol (MGDG) and for the activation of systemic acquired resistance ...
Katarzyna eLorenc-Kukula, Ratnesh eChaturvedi, Mary eRoth, Ruth eWelti, Jyoti eShah   +4 more
doaj   +1 more source

Changes in membrane lipids drive increased endocytosis following Fas ligation [PDF]

, 2017
Once activated, some surface receptors promote membrane movements that open new portals of endocytosis, in part to facilitate the internalization of their activated complexes.
Degli Esposti, Mauro, Garofalo, Tina, Khosravi Far, Roya, Longo, Agostina, Malorni, Walter, Matarrese, Paola, Misasi, Roberta, Recalchi, Serena, Sorice, Maurizio, Tinari, Antonella   +9 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]

, 2006
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E, Goldstein, Matthew J, Prod'homme, Thomas, Steinman, Lawrence, Weber, Martin S, Youssef, Sawsan, Zamvil, Scott S   +6 more
core   +1 more source

Lipid signalling [PDF]

Current Biology, 1998
Downes, C.Peter, Currie, Richard A
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality[S]

Journal of Lipid Research, 2013
Human mesenchymal stem/stromal cells (hMSC) are increasingly used in advanced cellular therapies. The clinical use of hMSCs demands sequential cell expansions.
Lotta Kilpinen, Feven Tigistu-Sahle, Sofia Oja, Dario Greco, Amarjit Parmar, Päivi Saavalainen, Janne Nikkilä, Matti Korhonen, Petri Lehenkari, Reijo Käkelä, Saara Laitinen   +10 more
doaj   +1 more source

Obesity-induced changes in lipid mediators persist after weight loss. [PDF]

, 2017
BackgroundObesity induces significant changes in lipid mediators, however, the extent to which these changes persist after weight loss has not been investigated.Subjects/methodsWe fed C57BL6 mice a high-fat diet to generate obesity and then switched the ...
Börgeson, E, Hernandez-Carretero, A, La Frano, MR, Lantero Rodriguez, J, Newman, JW, Osborn, O, Sears, DD, Wallenius, V, Weber, N, Ying, W   +9 more
core   +2 more sources

Serotonin Signaling through Lipid Membranes

ACS Chemical Neuroscience
Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental disorders. Primarily, membrane proteins controlling the expression and activity of 5-HT synthesis, storage, release, receptor activation, and inactivation are critical to
Liubov S. Kalinichenko, Johannes Kornhuber, Steffen Sinning, Jana Haase, Christian P. Müller   +4 more
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source