Results 91 to 100 of about 1,963,371 (292)

Extracellular Spermine Triggers a Rapid Intracellular Phosphatidic Acid Response in Arabidopsis, Involving PLDδ Activation and Stimulating Ion Flux

Frontiers in Plant Science, 2019
Polyamines, such as putrescine (Put), spermidine (Spd), and spermine (Spm), are low-molecular-weight polycationic molecules found in all living organisms.
Xavier Zarza, Xavier Zarza, Lana Shabala, Miki Fujita, Sergey Shabala, Michel A. Haring, Antonio F. Tiburcio, Teun Munnik, Teun Munnik   +8 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Lipid signals and insulin resistance

Clinical Lipidology, 2013
The metabolic syndrome, a cluster of metabolic derangements that include obesity, glucose intolerance, dyslipidemia and hypertension, is a major risk factor for cardiovascular disease. Insulin resistance has been proposed to be the common feature that links obesity to the metabolic syndrome, but the mechanism remains obscure.
Chongben, Zhang, Eric L, Klett, Rosalind A, Coleman   +2 more
openaire   +3 more sources

Biochemical and molecular-genetic characterization of SFD1’s involvement in lipid metabolism and defense signaling

Frontiers in Plant Science, 2012
The Arabidopsis thaliana SFD1 (SUPPRESSOR OF FATTY ACID DESATURASE DEFICIENCY1) gene (also known as GLY1) is required for accumulation of 34:6 (i.e., 18:3-16:3) monogalactosyldiacylglycerol (MGDG) and for the activation of systemic acquired resistance ...
Katarzyna eLorenc-Kukula, Ratnesh eChaturvedi, Mary eRoth, Ruth eWelti, Jyoti eShah   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Structural studies of Gαq signaling and regulation [PDF]

, 2008
textGαq signaling is implicated in a number of physiological processes that include platelet activation, cardiovascular development and smooth muscle function.
Shankaranarayanan, Aruna
core  

Transmembrane helix dynamics of bacterial chemoreceptors supports a piston model of signalling. [PDF]

, 2011
Transmembrane α-helices play a key role in many receptors, transmitting a signal from one side to the other of the lipid bilayer membrane. Bacterial chemoreceptors are one of the best studied such systems, with a wealth of biophysical and mutational data
Judith P Armitage, Judith P. Armitage, Sansom, MS, Armitage Judith P., Mark S P Sansom, Armitage, JP, Benjamin A Hall, Sansom Mark S. P., Hall, BA, Armitage, Judith, Benjamin A. Hall, Mark S. P. Sansom, Hall Benjamin A.   +12 more
core   +1 more source

Lipid signalling [PDF]

Current Biology, 1998
Downes, C.Peter, Currie, Richard A
openaire   +2 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

mTOR complex 2 - akt signaling is physically and functionally at mam [PDF]

, 2012
The target of rapamycin (TOR) is a conserved protein kinase and a central controller of growth. TOR can be part of two structurally and functionally distinct complexes, termed TOR complex 1 and TOR complex 2.
Betz, Charles
core   +1 more source