Results 151 to 160 of about 6,052,075 (348)

Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation [PDF]

, 2001
Robert T. Watson, Satoshi Shigematsu, Shian-Huey Chiang, Sílvia Mora, Makoto Kanzaki, Ian G. Macara, Alan R. Saltiel, Jeffrey E. Pessin   +7 more
openalex   +1 more source

Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell‐Based Model

Advanced Biology, EarlyView.
This study develops a tissue‐engineered model of the atherosclerotic cap using human mesenchymal stromal cells (MSCs). After 2 weeks of culture to produce a collagenous matrix, a mineralizing medium induces microcalcifications over 4 weeks. These constructs, imaged with second harmonic generation microscopy, lead to reduced ultimate stress at rupture ...
Imke L. Jansen, Deniz Şahin, Frank J.H. Gijsen, Eric Farrell, Kim van der Heiden   +4 more
wiley   +1 more source

New strategies for combating fungal infections: Inhibiting inositol lipid signaling by targeting Sec14 phosphatidylinositol transfer proteins. [PDF]

Adv Biol Regul, 2022
Bankaitis VA, Tripathi A, Chen XR, Igumenova TI.   +3 more
europepmc   +1 more source

GFRα-Mediated Localization of RET to Lipid Rafts Is Required for Effective Downstream Signaling, Differentiation, and Neuronal Survival

, 2000
Malú G. Tansey, Robert H. Baloh, Jeffrey Milbrandt, Eugene M. Johnson   +3 more
openalex   +1 more source

Extranuclear Lipid Bodies, Elicited by CCR3-mediated Signaling Pathways, Are the Sites of Chemokine-enhanced Leukotriene C4 Production in Eosinophils and Basophils [PDF]

, 2001
Christianne Bandeira‐Melo, Mojabeng Phoofolo, Peter F. Weller   +2 more
openalex   +1 more source

The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist

Advances in Physiology Education, 2007
Reviews of signal transduction have often focused on the cascades of protein kinases and protein phosphatases and their cytoplasmic substrates that become activated in response to extracellular signals. Lipids, lipid kinases, and lipid phosphatases have not received the same amount of attention as proteins in studies of signal transduction.
openaire   +3 more sources

Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?

Advanced Biology, EarlyView.
Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez, Hao Zhang, Dhananjay Sah, Juan P. Cata   +3 more
wiley   +1 more source

Inhibition of mitochondrial protein import and proteostasis by a pro-apoptotic lipid

eLife
Mitochondria-mediated cell death is critically regulated by bioactive lipids derived from sphingolipid metabolism. The lipid aldehyde trans-2-hexadecenal (t-2-hex) induces mitochondrial dysfunction from yeast to humans.
Josep Fita-Torró, José Luis Garrido-Huarte, Lucía López-Gil, Agnès H Michel, Benoit Kornmann, Amparo Pascual-Ahuir, Markus Proft   +6 more
doaj   +1 more source

Cannabinoids accumulate in mouse breast milk and differentially regulate lipid composition and lipid signaling molecules involved in infant development. [PDF]

BBA Adv, 2022
Johnson CT, de Abreu GHD, Mackie K, Lu HC, Bradshaw HB.   +4 more
europepmc   +1 more source

Lipid metabolism in T cell signaling and function

Nature Chemical Biology, 2022
S. A. Lim, Wei Su, Nicole M. Chapman, H. Chi   +3 more
semanticscholar   +1 more source