Results 251 to 260 of about 1,963,371 (292)

Glucagon and lipid signaling in the hypothalamus

Mammalian Genome, 2014
Hyperglycemia, caused in part by elevated hepatic glucose production (GP), is a hallmark feature of diabetes and obesity. The hypothalamus responds to hormones and nutrients to regulate hepatic GP and glucose homeostasis. This invited perspective focuses on the molecular signaling and biochemical pathways involved in the gluco-regulatory action of ...
Mary P, LaPierre, Mona A, Abraham, Beatrice M, Filippi, Jessica T Y, Yue, Tony K T, Lam   +4 more
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Membrane lipids as signaling molecules

Current Opinion in Lipidology, 2007
Membrane lipids play important roles in signaling reactions. They are involved in most if not all cellular signaling cascades and in a wide variety of tissue and cell types. The purpose of this review is to highlight major pathways of signaling originating in membrane lipids.
Aaron Z, Fernandis, Markus R, Wenk
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Lipid Rafts and Redox Signaling

Antioxidants & Redox Signaling, 2007
In addition to the amplifying action of enzymes in the cell-signaling cascade, another important mechanism has been shown to amplify the signals massively when ligands bind to their receptors, which is characterized by clustering of membrane lipid microdomains or lipid rafts and formation of various signaling platforms.
Pin-Lan, Li, Erich, Gulbins
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Lipid Peroxidation-Related Redox Signaling in Osteosarcoma

International Journal of Molecular Sciences
Oxidative stress and lipid peroxidation play important roles in numerous physiological and pathological processes, while the bioactive products of lipid peroxidation, lipid hydroperoxides and reactive aldehydes, act as important mediators of redox ...
Neven Zarkovic, Morana Jaganjac, Josipa Vlainić   +2 more
exaly   +2 more sources

Lipid rafts and signal transduction

Nature Reviews Molecular Cell Biology, 2000
Signal transduction is initiated by complex protein-protein interactions between ligands, receptors and kinases, to name only a few. It is now becoming clear that lipid micro-environments on the cell surface -- known as lipid rafts -- also take part in this process. Lipid rafts containing a given set of proteins can change their size and composition in
K, Simons, D, Toomre
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Lipid signaling in Drosophila photoreceptors

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2012
Drosophila photoreceptors are sensory neurons whose primary function is the transduction of photons into an electrical signal for forward transmission to the brain. Photoreceptors are polarized cells whose apical domain is organized into finger like projections of plasma membrane, microvilli that contain the molecular machinery required for sensory ...
Padinjat, Raghu, Shweta, Yadav, Naresh Babu Naidu, Mallampati   +2 more
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Lipids in Ca2+ signalling—An introduction

Cell Calcium, 2009
Lipids and lipid-derived metabolites are increasingly recognised as bonafide signalling molecules that regulate many cellular processes. These include the well-established InsP(3), diacylglycerol (DAG), PIP(2), PIP(3) and arachidonic acid (AA), as well as other poly-unsaturated fatty acids (PUFAs), lysophospholipids, sphingolipids, endocannabinoids and
Roger C, Hardie, Shmuel, Muallem
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Lipid rafts in cytokine signaling

Cytokine & Growth Factor Reviews, 2004
Lipid rafts are established as critical structures for a variety of cellular processes, including immune cell activation. Beyond their importance for initial immune cell activation at the immunological synapse, lipid rafts are now also being recognized as important sites for cytokine and growth factor signal transduction, both in immune cells as part ...
Rakesh, Rao, Barbara, Logan, Kathy, Forrest, Thomas L, Roszman, Jens, Goebel   +4 more
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Ethanol and Lipid Metabolic Signaling

Alcoholism: Clinical and Experimental Research, 2001
This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Shivendra D. Shukla and Grace Y. Sun. The presentations were (1) Metabolic turnover of ethanol into cellular lipids and platelet activating factor, by Shivendra D.
S D, Shukla, G Y, Sun, W, Gibson Wood, M J, Savolainen, C, Alling , J B, Hoek   +5 more
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Lipid Signaling and Synaptic Plasticity

The Neuroscientist, 2006
Lipids are essential components of plasma- and organelle-membranes, not only providing a frame for embedded proteins (e.g., receptors and ion channels) but also functioning as reservoirs for lipid mediators. Increasing evidence indicates that bioactive lipids such as eicosanoids, endocannabinoids, and lysophospholipids serve as ...
Nan, Sang, Chu, Chen
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