Results 271 to 280 of about 848,065 (307)

Inositol lipids in cell signalling

Current Biology, 1992
In the past year, major advances have been made in our understanding of the regulation of phosphoinositidase C, and of the action of the inositol trisphosphate receptor and how it may generate 'quantal' Ca2+ release. The functions of inositol tetrakisphosphate and of the 3-phosphorylated inositol lipids continue to generate controversy, but both may be
openaire   +2 more sources

Lipid Signaling in Experimental Epilepsy

Neurochemical Research, 2005
Glutamate release activates signaling pathways important for learning and memory, and over-stimulation of these pathways during seizures leads to aberrant synaptic plasticity associated with hyper-excitable, seizure-prone states. Seizures induce rapid accumulation of membrane lipid-derived fatty acids at the synapses which, evidence suggests, regulate ...
Kasie K, Cole-Edwards, Nicolas G, Bazan
openaire   +2 more sources

Lipid Signaling Protocols

2009
PART 1. Lipid systems and techniques Introduction - by Mike Wakelam 1) Eicosanoids: generation and detection in mammalian cells Valerie B. O'Donnell, Ben Maskrey and Graham W. Taylor. 2) Lipidomic analysis of phospholipids and related structures by liquid chromatography-mass spectrometry Trevor R.
openaire   +1 more source

Lipid signaling in pathogenic fungi

Current Opinion in Microbiology, 2006
Recent studies have highlighted the importance of lipid signaling molecules in the development and pathogenicity of clinically important fungi. In Cryptococcus neoformans, sphingolipid-derived diacylglycerol has been shown to induce the transcription of the putative virulence factor App1, which inhibits the phagocytosis of fungal cells by alveolar ...
John M, Shea, Maurizio, Del Poeta
openaire   +2 more sources

Lipid rafts and insulin signaling

American Journal of Physiology-Endocrinology and Metabolism, 2002
Lipid rafts are domains within the plasma membrane that are enriched in cholesterol and lipids with saturated acyl chains. Specific proteins, including many signaling proteins, segregate into lipid rafts, and this process is important for certain signal transduction events in a variety of cell types.
openaire   +2 more sources

Protein Lipidation in Cell Signaling

Science, 1995
The ability of cells to communicate with and respond to their external environment is critical for their continued existence. A universal feature of this communication is that the external signal must in some way penetrate the lipid bilayer surrounding the cell.
openaire   +2 more sources

Nuclear Lipid Metabolism and Signaling

Journal of Biochemistry, 2002
Evidence has been accumulating that nuclear lipid metabolism is involved in the regulation of nuclear functions. Here I describe an autonomous nuclear lipid signaling that has been found to be associated with the metabolism of such lipids as phosphoinositides, choline phospholipids, and the acylation and deacylation cycle.
openaire   +2 more sources

Introduction: Druggable Lipid Signaling Pathways

2020
Lipids are essential for life. They store energy, constitute cellular membranes, serve as signaling molecules, and modify proteins. In the long history of lipid research, many drugs targeting lipid receptors and enzymes that are responsible for lipid metabolism and function have been developed and applied to a variety of diseases.
openaire   +2 more sources

Nutrient-regulated control of lysosome function by signaling lipid conversion

Cell, 2023
Pathma Muthukottiappan, Wonyul Jang, Martin Lehmann   +2 more
exaly  

Nuclear inositol lipid signaling

Advances in Enzyme Regulation, 2001
L, Cocco, A M, Martelli, O, Barnabei, F A, Manzoli   +3 more
openaire   +2 more sources