Results 91 to 100 of about 23,453 (286)

The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

eLife, 2013
Autophagy is a catabolic process for bulk degradation of cytosolic materials mediated by double-membraned autophagosomes. The membrane determinant to initiate the formation of autophagosomes remains elusive.
Liang Ge, David Melville, Min Zhang, Randy Schekman   +3 more
doaj   +1 more source

HCV Interplay with Lipoproteins: Inside or Outside the Cells?

Viruses, 2020
Hepatitis C virus (HCV) infection is a major public health issue leading to chronic liver diseases. HCV particles are unique owing to their particular lipid composition, namely the incorporation of neutral lipids and apolipoproteins.
François-Loïc Cosset, Chloé Mialon, Bertrand Boson, Christelle Granier, Solène Denolly   +4 more
doaj   +1 more source

Identification of protein disulfide isomerase 1 as a key isomerase for disulfide bond formation in apolipoprotein B100 [PDF]

, 2015
Apolipoprotein (apo) B is an obligatory component of very low density lipoprotein (VLDL), and its cotranslational and posttranslational modifications are important in VLDL synthesis, secretion, and hepatic lipid homeostasis.
Chen, Zhouji, Davidson, Nicholas O, Han, Jaeseok, Kaufman, Randal J, Kodali, Vamsi K, Park, Shuin, Wang, Shiyu, Yip, Theresa   +7 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development [PDF]

, 2015
Novel multifunctional reagents were applied in combination with a lipid probe for affinity enrichment of myristoylated proteins and direct detection of lipid-modified tryptic peptides by mass spectrometry.
Boersema, Cox, Dieterich, Hannoush, Heal, Lin, Lin, Speers, Tate, Thinon, Vizcaíno, Wilson, Wright, Wright, Zhang, Zheng   +15 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitros⃞

Journal of Lipid Research, 2009
Pharmacologic approaches to studying palmitoylation are limited by the lack of specific inhibitors. Recently, screens have revealed five chemical classes of small molecules that inhibit cellular processes associated with palmitoylation (Ducker, C. E., L.
Benjamin C. Jennings, Marissa J. Nadolski, Yiping Ling, Meredith Beckham Baker, Marietta L. Harrison, Robert J. Deschenes, Maurine E. Linder   +6 more
doaj   +1 more source

Chloroplast damage induced by the inhibition of fatty acid synthesis triggers autophagy in chlamydomonas [PDF]

, 2018
Fatty acids are synthesized in the stroma of plant and algal chloroplasts by the fatty acid synthase complex. Newly synthesized fatty acids are then used to generate plastidial lipids that are essential for chloroplast structure and function.
Andrés Garrido, Ascensión, Crespo González, José Luis, Heredia Martínez, Luis G., Martínez Force, Enrique, Pérez Pérez, Maria Esther   +4 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Metamorphosis and development of malaria parasites in the liver are regulated by unconventional autophagy

Autophagy Reports
Malaria parasites encounter diverse conditions as they transition between mosquito and mammalian hosts. A characteristic of the sporozoite stage of the parasite is that once it enters the hepatocyte, it changes its morphology and metabolism.
Suryansh Rajput, Satish Mishra
doaj   +1 more source