Results 81 to 90 of about 17,356 (288)
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Artificial Cells, Nanomedicine, and BiotechnologyLipidation enhances the antimicrobial potential of cationic peptides by increasing amphiphilicity. The nuclear localization signal peptide PKKKRKV, although cell-penetrating, has weak intrinsic antimicrobial activity.
Rani Maharani +8 more
doaj +1 more source
Relation of the size and intracellular sorting of apoB to the formation of VLDL 1 and VLDL 2
Journal of Lipid Research, 2005 In this study, we tested the hypothesis that two separate pathways, the two-step process and an apolipoprotein B (apoB) size-dependent lipidation process, give rise to different lipoproteins.
Pia Stillemark-Billton +3 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Lipid Sorting: Lipids Do It on Their Own [PDF]
Current Biology, 2005 How are lipid molecules sorted between organelles in eukaryotic cells? A recent paper shows that the work needed to bend a membrane and form a vesicle is sufficient to sort lipid molecules.
openaire +3 more sources
VaccinesToll-like receptor 2 (TLR2) signaling is a pivotal component of immune system activation, and it is closely linked to the lipidation of bacterial proteins.
Muhammad Umar +3 more
doaj +1 more source
Recombinant Expression and Stapling of a Novel Long-Acting GLP-1R Peptide Agonist
Molecules, 2020 Owing to their pleiotropic metabolic benefits, glucagon-like peptide-1 receptor (GLP-1R) agonists have been successfully utilized for treating metabolic diseases, such as type 2 diabetes and obesity.
Sam Lear +9 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Lipids and lipid domains of the yeast vacuole
Biochemical Society Transactions, 2018 The membrane raft has been a focus of intensive research for the past two decades. Liquid-ordered domains form in artificial liposomes containing sterol and saturated lipids, but their presence in living cell membranes has been controversial. The yeast vacuole is exceptional in that micron-sized raft-like domains form in the stationary phase and under ...
Takuma, Tsuji, Toyoshi, Fujimoto
openaire +2 more sources
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source