Results 91 to 100 of about 17,356 (288)

Shuffled lipidation pattern and degree of lipidation determines the membrane interaction behavior of a linear cationic membrane-active peptide

, 2020
Hypothesis: Permeation of macromolecular drugs across biological plasma membranes is a major chal-lenge in drug delivery. Cationic cell-penetrating peptides (CPPs) are attractive functional excipient can-didates for the delivery of macromolecules across ...
Khandelia, Himanshu,, Khandelia, Himanshu, Bruhn, Dennis Skjøth, Cardenas, Marite, Bruhn, Dennis Skjøth,, Nielsen, Hanne Mørck,, Nielsen, Hanne Morck, Khandelia, Himanshu; id_orcid, Hedegaard, Sofie Fogh,, Bruhn, Dennis Skjoth, Nielsen, Hanne Mørck, Cárdenas, Marité,, Hedegaard, Sofie Fogh   +12 more
core   +1 more source

Isoform- and cell-state-specific lipidation of ApoE in astrocytes

, 2022
Dataset corresponding to raw normalised data related to "Isoform- and cell-state specific lipidation of ApoE in astrocytes" by Lindner and Beckenbauer et al.
Lindner, K (via Mendeley Data)
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2+-dependent calcineurin signaling

Journal of Lipid Research, 2010
ATP-binding cassette transporter A1 (ABCA1) is required for the lipidation of apolipoprotein A-I (apoA-I), although molecular mechanisms supporting this process remain poorly defined.
Joel Karwatsky, Loretta Ma, Fumin Dong, Xiaohui Zha   +3 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi

eLife
NLRP3 is an inflammasome seeding pattern recognition receptor activated in response to multiple danger signals which perturb intracellular homeostasis.
Daniel M Williams, Andrew A Peden
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitros⃞

Journal of Lipid Research, 2009
Pharmacologic approaches to studying palmitoylation are limited by the lack of specific inhibitors. Recently, screens have revealed five chemical classes of small molecules that inhibit cellular processes associated with palmitoylation (Ducker, C. E., L.
Benjamin C. Jennings, Marissa J. Nadolski, Yiping Ling, Meredith Beckham Baker, Marietta L. Harrison, Robert J. Deschenes, Maurine E. Linder   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Regulation of LC3 lipidation by the autophagy-specific class III phosphatidylinositol-3 kinase complex. [PDF]

, 2019
Autophagy is a conserved eukaryotic pathway critical for cellular adaptation to changes in nutrition levels and stress. The class III phosphatidylinositol (PI)3-kinase complexes I and II (PI3KC3-C1 and -C2) are essential for autophagosome initiation and ...
Stjepanovic, Goran, Ge, Liang, Hurley, James H, Schekman, Randy, Thelen, Ashley M, Brier, Livia W   +5 more
core   +1 more source