Results 111 to 120 of about 23,453 (286)
Post-Translational Modification and Subcellular Distribution of Rac1: An Update
Cells, 2018 Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of cellular effects, including regulation of cytoarchitecture, cell size, cell ...
Abdalla Abdrabou, Zhixiang Wang
doaj +1 more source
The study on protein level, lipidation state and protein stability of apolipoprotein E [PDF]
, 2015 阿尔兹海默症（Alzheimer’sdisease，AD）是老年人群中最常见的痴呆类型。按AD的发病年龄可以将AD划分为早发型AD和晚发型AD，绝大多数的AD病人属于晚发型AD。载脂蛋白E（apoE）存在ε2、ε3、ε4三种常见的等位基因，其中的ε4等位基因是晚发型AD最重要的危险因素，而ε2等位基因可以降低人类罹患阿尔兹海默症的风险。ApoE是脑中主要的载脂蛋白，在脑中胆固醇及其它脂质的运输过程中发挥重要作用。ApoE通过调节Aβ的清除及脂质转运等机制在AD的病理学过程中发挥重要作用 ...
史新震
core
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
, 2010 Binding, lateral diffusion and exchange are fundamental dynamic processes involved in protein association with cellular membranes. In this study, we developed numerical simulations of lateral diffusion and exchange of fluorophores in membranes with ...
Daniel A Beard +10 more
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Sustainable bioplastics manufacturing from renewable sources
FEBS Open Bio, EarlyView.Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto +6 more
wiley +1 more source
Editorial: Protein lipidation in health and disease
Frontiers in Physiology, 2023 William Fuller +2 more
doaj +1 more source
Effects of ApoE Isoforms Expression on Brain ApoE Lipidation and Amyloid-β Accumulation [PDF]
, 2015 在编码人三种不同apoE蛋白亚型（E2、E3和E4）的APOE等位基因（ε2、ε3和ε4）中，APOEε4等位基因是阿尔茨海默病（Alzheimer’sdisease，AD）最重要的遗传风险因子，APOEε2等位基因则具有保护作用。鉴于apoE蛋白亚型对基于调节apoE蛋白表达的AD治疗可能会有不同的影响，我们通过在人APOE基因定位替换（Targetedreplacement，TR）小鼠脑中过表达不同的人apoE亚型，研究脑中表达不同apoE亚型对apoE脂化和β-淀粉样蛋白（Amyloid-β，Aβ）
胡进
core
FEBS Open Bio, EarlyView.Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source