Results 81 to 90 of about 23,453 (286)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The regulation of the autophagic network and its implications for human disease [PDF]

, 2013
Autophagy has attracted a lot of attention in recent years. More and more proteins and signaling pathways have been discovered that somehow feed into the autophagy regulatory pathways.
Carra, Serena, Kampinga, Harm H., Yang, Jing, Zhu, Wei Guo   +3 more
core   +7 more sources

Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2+-dependent calcineurin signaling

Journal of Lipid Research, 2010
ATP-binding cassette transporter A1 (ABCA1) is required for the lipidation of apolipoprotein A-I (apoA-I), although molecular mechanisms supporting this process remain poorly defined.
Joel Karwatsky, Loretta Ma, Fumin Dong, Xiaohui Zha   +3 more
doaj   +1 more source

Recombinant Expression and Stapling of a Novel Long-Acting GLP-1R Peptide Agonist

Molecules, 2020
Owing to their pleiotropic metabolic benefits, glucagon-like peptide-1 receptor (GLP-1R) agonists have been successfully utilized for treating metabolic diseases, such as type 2 diabetes and obesity.
Sam Lear, Hyosuk Seo, Candy Lee, Lei Lei, Zaid Amso, David Huang, Huafei Zou, Zhihong Zhou, Vân T. B. Nguyen-Tran, Weijun Shen   +9 more
doaj   +1 more source

The effect of lipidation on the self-assembly of the gut-derived peptide hormone PYY3–36 [PDF]

, 2018
Lipidation is a powerful strategy to improve the stability in vivo of peptide drugs. Attachment of a lipid chain to a hydrophilic peptide leads to amphiphilicity and the potential for surfactant-like self-assembly.
Burholt, Samuel, Gomes dos Santos, Ana, Hamley, Ian W., Hutchinson, Jessica A., Lundback, Anna-Karin, Reza, Mehedi, Ruokolainen, Janne, Seitsonen, Jani, Uddin, Shahid   +8 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Lipidation Approaches Potentiate Adjuvant-Pulsed Immune Surveillance: A Design Rationale for Cancer Nanovaccine

Frontiers in Bioengineering and Biotechnology, 2020
Adjuvant-pulsed peptide vaccines hold great promise for the prevention and treatment of different diseases including cancer. However, it has been difficult to maximize vaccine efficacy due to numerous obstacles including the unfavorable tolerability ...
Junqing Wang, Junqing Wang, Harshal Zope, Mohammad Ariful Islam, Mohammad Ariful Islam, Jamie Rice, Jamie Rice, Sage Dodman, Kevin Lipert, Yunhan Chen, Bruce R. Zetter, Jinjun Shi   +11 more
doaj   +1 more source

Autophagy mediates degradation of nuclear lamina [PDF]

, 2015
Z.D. is supported by a fellow award from the Leukemia & Lymphoma Society. B.C.C. is supported by career development awards from the Dermatology Foundation, Melanoma Research Foundation, and American Skin Association. S.L.B., P.D.A. and R.M. are supported
A Freund, A Ivanov, AM Choi, AR Young, B Levine, BH Toyama, D Wiederschain, E Lund, EN N’Diaye, H Liu, HU Simon, IH Lee, JA Pan, K Mochida, KR Drake, L Guelen, M Collado, M Sadaie, M Serrano, MA Larkin, N Mizushima, N Mizushima, N Mizushima, O Dreesen, P Roberts, PP Shah, R Huang, S Pankiv, T Chandra, T Shimi, T Shimi, TK Kerppola, V Butin-Israeli, V Kirkin, V Rogov, Y Kabeya, Y Zhong, Z Dou   +37 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source