Results 71 to 80 of about 30,990 (296)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Modulation of the phospholipid transfer protein-mediated transfer of phospholipids by diacylglycerols

Journal of Lipid Research, 2001
Previous studies have shown that diacylglycerols (DAG) are formed during triglyceride hydrolysis in very low density lipoproteins (VLDL), a process that is accompanied by an elevated phospholipid transfer protein (PLTP)-mediated transfer of phopholipids (
Florent Lalanne, Claude Motta, Yan Pafumi, Denis Lairon, Gabriel Ponsin   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Profil Lipoprotéique et Risque Athérogène chez les Drépanocytaires Majeurs au CHU de Cocody

Health Research in Africa
RESUME Introduction. Les formes majeures de drépanocytose sont une source de perturbation des paramètres lipidiques. Cette perturbation est impliquée dans l’apparition de nombreuses maladies cardiovasculaires telles que les accidents vasculaires ...
Vanie BFG, Kouame BGM, Niamke AGG, Koudou CC, Yapo ACB, Lohore KC, Allou AAA   +6 more
doaj   +1 more source

Libération des acides gras par autolyse enzymatique des triglycérides des graines oléoprotéagineuses

Oléagineux, Corps gras, Lipides, 2001
Les acides gras produits par hydrolyse chimique des lipides des plantes sont des matériaux de base pour l’industrie des biocarburants, des lubrifiants, des plastiques, des détergents et également des adjuvants de préparations commerciales d’herbicides ...
Alibert Gilbert, Mouloungui Zéphirin, Grison René, Romestan Michel   +3 more
doaj   +1 more source

Cholesteryl ester transfer protein (CETP), HDL capacity of receiving cholesterol and status of inflammatory cytokines in patients with severe heart failure

Lipids in Health and Disease, 2018
Background Heart failure (HF) courses with chronic inflammatory process and alterations in lipid metabolism may aggravate the disease. The aim was to test whether the severity of HF, using brain natriuretic peptide (BNP) as a marker, is associated with ...
Ana Elisa M. Martinelli, Raul C. Maranhão, Priscila O. Carvalho, Fatima R. Freitas, Bruna M. O. Silva, Milena N. C. Curiati, Roberto Kalil Filho, Antonio Carlos Pereira-Barretto   +7 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Mise en place des tissus adipeux sous-cutanés et intramusculaires et facteurs de variation quantitatifs et qualitatifs chez le porc

INRAE Productions Animales, 2001
Le choix de la matière première lipidique dans l’alimentation du porc est particulièrement important. Il est bien connu qu’il existe une relation entre la nature des acides gras ingérés et ceux qui vont se déposer dans le tissu adipeux et à un degré ...
J. MOUROT
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The products of peroxide lipids oxidations and bioantioxidants – glutathione and ascorbic acid of galophytes Salsola soda L., Glaucium flavum Crambs. and Euphorbia peplus L.

Інтродукція Рослин, 2012
Process intensity of lipides peroxidation and bioantioxidants – glutathicone and different forms of ascorbic acid content in galophytes we analyzed Salsola soda L., Glaucium flavum Crambs. and Euphorbia peplus L. were studied.
I.V. Kosakivska, V.H. Gryshko, D.V. Syshchikov, A. Ivanova   +3 more
doaj   +1 more source