Results 51 to 60 of about 21,627 (236)

Tutorial on lipidomics [PDF]

Analytica Chimica Acta, 2019
The mainstream of lipidomics involves mass spectrometry-based, systematic, and large-scale studies of the structure, composition, and quantity of lipids in biological systems such as organs, cells, and body fluids. As increasingly more researchers in broad fields are beginning to pay attention to and actively learn about the lipidomic technology, some ...
Jianing Wang, Chunyan Wang, Xianlin Han
openaire   +2 more sources

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Lipidomic Profiling Reveals HSD17B13 Deficiency-Associated Dysregulated Hepatic Phospholipid Metabolism in Aged Mice

Metabolites
Objectives: HSD17B13 (17β-hydroxysteroid dehydrogenase 13), a lipid droplet-associated enzyme, has emerged as a key regulator of hepatic lipid metabolism and a potential therapeutic target for metabolic-associated fatty liver disease (MAFLD).
Cong Zhang, Yingxin Feng, Xiaoyan Zhang, Youfei Guan, Wen Su   +4 more
doaj   +1 more source

Lipid Annotation by Combination of UHPLC-HRMS (MS), Molecular Networking, and Retention Time Prediction: Application to a Lipidomic Study of In Vitro Models of Dry Eye Disease

Metabolites, 2020
Annotation of lipids in untargeted lipidomic analysis remains challenging and a systematic approach needs to be developed to organize important datasets with the help of bioinformatic tools.
Romain Magny, Anne Regazzetti, Karima Kessal, Gregory Genta-Jouve, Christophe Baudouin, Stéphane Mélik-Parsadaniantz, Françoise Brignole-Baudouin, Olivier Laprévote, Nicolas Auzeil   +8 more
doaj   +1 more source

Lipidomic Characterization of Oocytes at Single-Cell Level Using Nanoflow Chromatography-Trapped Ion Mobility Spectrometry-Mass Spectrometry

Molecules, 2023
Mass spectrometry (MS)-based lipidomic has become a powerful tool for studying lipids in biological systems. However, lipidome analysis at the single-cell level remains a challenge.
Pujia Zhu, Guowei Bu, Ruifeng Hu, Xianqin Ruan, Rongrong Fu, Zhourui Zhang, Qiongqiong Wan, Xin Liu, Yiliang Miao, Suming Chen   +9 more
doaj   +1 more source

Development of Artificial Sebaceous Gland‐Integrated In Vitro Human Skin Model

Advanced Materials Interfaces, EarlyView.
Uniform 3D artificial sebaceous gland spheroids, termed SebaSpheres, are generated at high throughput using a microfluidic platform and structurally integrated into a collagen‐based skin construct containing fibroblasts and keratinocytes. This work presents a modular and scalable fabrication and integration strategy for incorporating sebaceous gland ...
Daeun Ryu, Hyewon Noh, Jimin Son, Haejung Lee, Bo Mi Kang, Chong Won Choi, Jong Hwan Sung, Jae Jung Kim   +7 more
wiley   +1 more source

Integrative Analysis of Transcriptomic and Lipidomic Profiles Reveals a Differential Subcutaneous Adipose Tissue Mechanism among Ningxiang Pig and Berkshires, and Their Offspring

Animals, 2023
Adipose tissue composition contributes greatly to the quality and nutritional value of meat. Transcriptomic and lipidomic techniques were used to investigate the molecular mechanisms of the differences in fat deposition in Ningxiang pigs, Berkshires and ...
Xiaoxiao Deng, Yuebo Zhang, Gang Song, Yawei Fu, Yue Chen, Hu Gao, Qian Wang, Zhao Jin, Yulong Yin, Kang Xu   +9 more
doaj   +1 more source

Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants

Advanced Science, EarlyView.
In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao, Yanbin Li, Shengqi Zhang, Yilin He, Zhiqi Liu, Juan Wang, Jingmin Hua, Jinyu Chen, Junru Zhong, Huan Zhong, Yiji Xia, Yong Cui, Liwen Jiang   +12 more
wiley   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Acute Stress-Induced Changes in the Lipid Composition of Cow’s Milk in Healthy and Pathological Animals

Molecules, 2023
Producers of milk and dairy products have been faced with the challenge of responding to European society’s demand for guaranteed animal welfare production.
Yaiza Garro-Aguilar, Roberto Fernández, Silvia Calero, Ekaterina Noskova, Marina Gulak, Miguel de la Fuente, Albert Adell, Edurne Simón, Urko Muzquiz, Diego Rodríguez-Piñón, Egoitz Astigarraga, Gabriel Barreda-Gómez   +11 more
doaj   +1 more source