Results 91 to 100 of about 57,903 (321)

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

A Mouse Macrophage Lipidome [PDF]

Journal of Biological Chemistry, 2010
We report the lipidomic response of the murine macrophage RAW cell line to Kdo(2)-lipid A, the active component of an inflammatory lipopolysaccharide functioning as a selective TLR4 agonist and compactin, a statin inhibitor of cholesterol biosynthesis.
Dennis, Edward A, Deems, Raymond A, Harkewicz, Richard, Quehenberger, Oswald, Brown, H Alex, Milne, Stephen B, Myers, David S, Glass, Christopher K, Hardiman, Gary, Reichart, Donna, Merrill, Alfred H, Sullards, M Cameron, Wang, Elaine, Murphy, Robert C, Raetz, Christian RH, Garrett, Teresa A, Guan, Ziqiang, Ryan, Andrea C, Russell, David W, McDonald, Jeffrey G, Thompson, Bonne M, Shaw, Walter A, Sud, Manish, Zhao, Yihua, Gupta, Shakti, Maurya, Mano R, Fahy, Eoin, Subramaniam, Shankar   +27 more
openaire   +4 more sources

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Analysis and Quantification of the Mitochondrial–ER Lipidome

Bio-Protocol
Mitochondria are vital organelles essential for cellular functions, but their lipid composition and response to stressors are not fully understood.
Alexis Diaz-Vegas, Anthony Don, James Burchfield   +2 more
doaj   +1 more source

Translational potential of long-term decreases in mitochondrial lipids in a mouse model of Gulf War Illness [PDF]

, 2016
Gulf War Illness (GWI) affects 25% of veterans from the 1990–1991 Gulf War (GW) and is accompanied by damage to the brain regions involved in memory processing. After twenty-five years, the chronic pathobiology of GWI is still unexplained.
Abdullah, Laila, Ait-Ghezala, Ghania, Bachmeier, Corbin, Baumann, Stephan, Crawford, Fiona, Crynen, Gogce, Emmerich, Tanja, Evans, James E., Joshi, Utsav, Klimas, Nancy, Montague, Hannah, Mouzon, Benoit, Mullan, Michael, Reed, Jon, Sullivan, Kimberly, Zakirova, Zuchra   +15 more
core   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Lipidomic analysis of fats and oils – a lot more than just omega-3 [PDF]

, 2014
TKS research is supported in part by the Wellcome Trust, SUSLA, BBSRC and the European Community’s Seventh Framework Programme under grant agreement No.
Smith, Terry K
core   +1 more source

SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum [PDF]

, 2020
Chiara Bruzzone, Maider Bizkarguenaga, Rubén Gil‐Redondo, Tammo Diercks, Eunate Arana‐Arri, Aitor García de Vicuña, Marisa Seco, Alexandre Bosch, Asís Palazón, Itxaso San Juan, Ana Laín, Jon Gil‐Martínez, Ganeko Bernardo‐Seisdedos, David Fernández‐Ramos, Fernando Lopitz‐Otsoa, Nieves Embade, Shelly C. Lu, José M. Mato, Óscar Millet   +18 more
openalex   +1 more source

A High Throughput Lipidomics Method Using Scheduled Multiple Reaction Monitoring [PDF]

, 2022
Akash Kumar Bhaskar, Salwa Naushin, Arjun Ray, Praveen Singh, Anurag Raj, Shalini Pradhan, Khushboo Adlakha, Towfida Jahan Siddiqua, Dipankar Malakar, Debasis Dash, Shantanu Sengupta   +10 more
openalex   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source