Results 141 to 150 of about 47,866 (282)

Systematic analysis of choline-containing phospholipids using multi-dimensional mass spectrometry-based shotgun lipidomics [PDF]

, 2009
Kui Yang, Zhongdan Zhao, Richard W. Gross, Xianlin Han   +3 more
openalex   +1 more source

Plasmalogen as a Bioactive Lipid Drug: From Preclinical Research Challenges to Opportunities in Nanomedicine

FASEB BioAdvances, EarlyView.
Plasmalogens are specialized lipids affecting the membrane structure, dynamics, and key cell signaling pathways. They protect cells from oxidative damage. Plasmalogen deficiency is associated with severe diseases. Lipid nanoparticles and nanomedicine offer unexplored therapeutic potential for restoring plasmalogen levels under pathological conditions ...
Yu Wu, Yuru Deng, Borislav Angelov, Angelina Angelova   +3 more
wiley   +1 more source

Phosphorylation of an RNA‐Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging

Aging Cell, EarlyView.
Evolutionary conserved Hippo/Mst1 signaling non‐canonically regulates the stability of mRNAs through directly phosphorylating a subset of RNA binding proteins to stabilize lipolytic mRNAs. Hpo pathway contributes to the regulation of Drosophila lifespan by modulating the expression and activity of Me31b/RCK, which subsequently affects mRNA levels of ...
Eunbyul Yeom, Hyejin Mun, Jinhwan Lim, Yoo Lim Chun, Kyung‐Won Min, Johana Lambert, L. Ashley Cowart, Jason S. Pierce, Besim Ogretmen, Jung‐Hyun Cho, Jeong Ho Chang, J. Ross Buchan, Jason Pitt, Matt Kaeberlein, Sung‐Ung Kang, Eun‐Soo Kwon, Seungbeom Ko, Kyoung‐Min Choi, Yong Sun Lee, Yoon‐Su Ha, Seung‐Jin Kim, Kwang‐Pyo Lee, Hyo‐Sung Kim, Seo Young Yang, Chang Hoon Shin, Je‐Hyun Yoon, Kyu‐Sun Lee   +26 more
wiley   +1 more source

Lipidomic analyses of the mouse brain after antidepressant treatment: evidence for endogenous release of long-chain fatty acids? [PDF]

, 2009
Lynette Hui-Wen Lee, Guanghou Shui, Akhlaq A. Farooqui, Markus R. Wenk, Chay Hoon Tan, Wei‐Yi Ong   +5 more
openalex   +1 more source

Multi‐Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single‐Blinded Randomized Placebo‐Controlled Therapeutic Plasma Exchange

Aging Cell, EarlyView.
Therapeutic plasma exchange safely reduces biological age by up to 2.6 years. Multi‐omics analysis reveals coordinated cellular and molecular responses associated with aging rejuvenation. ABSTRACT We conducted a randomized, placebo‐controlled trial to assess the safety and biological age (BA) effects of various therapeutic plasma exchange (TPE ...
Matias Fuentealba, Dobri Kiprov, Kevin Schneider, Wei‐Chieh Mu, Prasanna Ashok Kumaar, Herbert Kasler, Jordan B. Burton, Mark Watson, Heather Halaweh, Christina D. King, Zehra Stara Yüksel, Chelo Roska‐Pamaong, Birgit Schilling, Eric Verdin, David Furman   +14 more
wiley   +1 more source

Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies [PDF]

, 2009
Hye Jung Park, Christopher A. Haynes, Alison V. Nairn, Michael Kulik, Stephen Dalton, Kelley W. Moremen, Alfred H. Merrill   +6 more
openalex   +1 more source

Multiomic Integration Analysis for Monitoring Severe Asthma Treated With Mepolizumab or Omalizumab

Allergy, EarlyView.
Mepolizumab and omalizumab induce a distinct clinical effect. Mepolizumab and omalizumab induce both common and treatment‐specific metabolic and protein profiles over time in patients with severe asthma. Multiomic integration and receiver operating characteristic curve analyses reveal a specific set of biomolecules suggesting their value as potential ...
Nuria Contreras, Andrea Escolar‐Peña, María I. Delgado‐Dolset, Paloma Fernández, David Obeso, Elena Izquierdo, Heleia González Cuervo, José Ángel Cumplido, Victoria Múgica, Carolina Cisneros, Santiago Angulo‐Díaz‐Parreño, Coral Barbas, Carlos Blanco, Teresa Carrillo, Domingo Barber, Alma Villaseñor, María M. Escribese   +16 more
wiley   +1 more source

Lipidomic approaches to the study of phospholipase A2-regulated phospholipid fatty acid incorporation and remodeling [PDF]

, 2009
David Balgoma, Olimpio Montero, Marı́a A. Balboa, Jesús Balsinde   +3 more
openalex   +1 more source

Combining lipidomics and machine learning to identify lipid biomarkers for nonsyndromic cleft lip with palate. [PDF]

JCI Insight
Jia S, Xie W, Yang C, Dong Y, Luo W, Gu H, Wei X, Ma W, Liu D, Cao S, Bai Y, Li W, Yuan Z.   +12 more
europepmc   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source