Results 11 to 20 of about 51,608 (289)
Lipidomics of Glycosphingolipids [PDF]
Metabolites, 2012 Glycosphingolipids (GSLs) contain one or more sugars that are attached to a sphingolipid moiety, usually to a ceramide, but in rare cases also to a sphingoid base. A large structural heterogeneity results from differences in number, identity, linkage, and anomeric configuration of the carbohydrate residues, and also from structural differences within ...
Farwanah, Hany, Kolter, Thomas
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Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W
Nature Communications, 2021 UBE2W catalyzes the ubiquitination of protein N-termini but its substrate spectrum is largely unknown. Here, the authors discover mAbs selective for peptides derived from N-terminally ubiquitinated proteins, solve the structure of a peptide-bound mAb and
Christopher W. Davies +15 more
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Myocardial Lipidomics. Developments in myocardial nuclear lipidomics [PDF]
Frontiers in Bioscience, 2007 The development of electrospray ionization mass spectrometry has been critical for the analyses of lipidomes from subcellular organelles. The myocardial nuclear lipidome likely has a key role in the molecular regulation of gene expression. In fact, recent studies have suggested that specific phospholipid classes bind and regulate specific transcription
Carolyn J, Albert +4 more
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BMC Pulmonary Medicine, 2021 Background Chronic obstructive pulmonary disease (COPD) exacerbations are heterogenous and profoundly impact the disease trajectory. Bioactive lipid lysophosphatidic acid (LPA) has been implicated in airway inflammation but the significance of LPA in ...
Qingling Li +12 more
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Chaperone mediated detection of small molecule target binding in cells
Nature Communications, 2020 Quantitative profiling of small molecule-protein binding in cells can aid basic biochemical research and drug discovery. Here, the authors develop the Heat Shock Protein Inhibition Protein Stability Assay (HIPStA) as a high-throughput method to assess ...
Kelvin F. Cho +5 more
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Biomolecules, 2023 Clinical data implicate fluctuations of high levels of plasma glucose in cardiovascular diseases. Endothelial cells (EC) are the first cells of the vessel wall exposed to them.
Laura Toma +5 more
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Defining Acute Coronary Syndrome through Metabolomics
Metabolites, 2021 As an emerging platform technology, metabolomics offers new insights into the pathomechanisms associated with complex disease conditions, including cardiovascular diseases.
Arun Surendran +4 more
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Frontiers in Physiology, 2013 Not all of the mysteries of life lie in our genetic code. Some can be found buried in our membranes. These shells of fat, sculpted in the central nervous system into the cellular (and subcellular) boundaries of neurons and glia, are themselves complex ...
Steffany A L Bennett +11 more
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Monitoring cancer prognosis, diagnosis and treatment efficacy using metabolomics and lipidomics [PDF]
, 2016 Introduction: Cellular metabolism is altered during cancer initiation and progression, which allows cancer cells to increase anabolic synthesis, avoid apoptosis and adapt to low nutrient and oxygen availability.
Armitage, Emily G., Southam, Andrew D.
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, 2023 Lipids are historically considered a source of energy and a component of cell membranes. Over the last years, many other functions have been studied, and their importance in our health is well established. For this reason, studies on lipidomics have been increasing in the clinical and food science areas.
Machado, Manuela +3 more
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