Results 21 to 30 of about 40,787 (289)
Variability of Lipids in Human Milk
Metabolites, 2021 Lipids in breastmilk play a critical role in infant growth and development. However, few studies have investigated sources of variability of both high- and low-abundant milk lipids.
Jayashree Selvalatchmanan +8 more
doaj +1 more source
Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W
Nature Communications, 2021 UBE2W catalyzes the ubiquitination of protein N-termini but its substrate spectrum is largely unknown. Here, the authors discover mAbs selective for peptides derived from N-terminally ubiquitinated proteins, solve the structure of a peptide-bound mAb and
Christopher W. Davies +15 more
doaj +1 more source
Plant Signaling & Behavior, 2011 A wealth of information related to lipid metabolism and signaling has been revealed in recent years using mass spectrometric-based lipidomics methods. Although quantitatively sensitive, these compositional profiling methods rely on conventional tissue extractions of total lipids which results in a loss of original cellular context of lipid metabolites.
Patrick J, Horn, Kent D, Chapman
openaire +2 more sources
A DMS Shotgun Lipidomics Workflow Application to Facilitate High-Throughput, Comprehensive Lipidomics [PDF]
, 2021 Differential mobility spectrometry (DMS) is highly useful for shotgun lipidomic analysis because it overcomes difficulties in measuring isobaric species within a complex lipid sample and allows for acyl tail characterization of phospholipid species ...
Daniel Hornburg +21 more
core +3 more sources
BMC Pulmonary Medicine, 2021 Background Chronic obstructive pulmonary disease (COPD) exacerbations are heterogenous and profoundly impact the disease trajectory. Bioactive lipid lysophosphatidic acid (LPA) has been implicated in airway inflammation but the significance of LPA in ...
Qingling Li +12 more
doaj +1 more source
Advanced Drug Delivery Reviews, 2020 Lipids are ubiquitous in the human organism and play essential roles as components of cell membranes and hormones, for energy storage or as mediators of cell signaling pathways. As crucial mediators of the human metabolism, lipids are also involved in metabolic diseases, cardiovascular and renal diseases, cancer and/or hepatological and neurological ...
Wu, Zhuojun +3 more
+4 more sources
Chaperone mediated detection of small molecule target binding in cells
Nature Communications, 2020 Quantitative profiling of small molecule-protein binding in cells can aid basic biochemical research and drug discovery. Here, the authors develop the Heat Shock Protein Inhibition Protein Stability Assay (HIPStA) as a high-throughput method to assess ...
Kelvin F. Cho +5 more
doaj +1 more source
Biomolecules, 2023 Clinical data implicate fluctuations of high levels of plasma glucose in cardiovascular diseases. Endothelial cells (EC) are the first cells of the vessel wall exposed to them.
Laura Toma +5 more
doaj +1 more source
Defining Acute Coronary Syndrome through Metabolomics
Metabolites, 2021 As an emerging platform technology, metabolomics offers new insights into the pathomechanisms associated with complex disease conditions, including cardiovascular diseases.
Arun Surendran +4 more
doaj +1 more source
Frontiers in Physiology, 2013 Not all of the mysteries of life lie in our genetic code. Some can be found buried in our membranes. These shells of fat, sculpted in the central nervous system into the cellular (and subcellular) boundaries of neurons and glia, are themselves complex ...
Steffany A L Bennett +11 more
doaj +1 more source